CHICK:MSX2

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	MSX2 (synonyms: HOX8)
Protein Name(s)	Homeobox protein MSX-2 Homeobox protein Hox-8 CHOX-8 GHox-8
External Links
UniProt	P28362
EMBL	S64478 X62097 X62541
PIR	JS0660
RefSeq	NP_989890.1
UniGene	Gga.4977
ProteinModelPortal	P28362
SMR	P28362
STRING	9031.ENSGALP00000004650
PaxDb	P28362
PRIDE	P28362
Ensembl	ENSGALT00000043501
GeneID	395245
KEGG	gga:395245
CTD	4488
eggNOG	NOG298790
GeneTree	ENSGT00770000120486
HOGENOM	HOG000231922
HOVERGEN	HBG005205
InParanoid	P28362
KO	K09341
OMA	PPKEMSS
PhylomeDB	P28362
TreeFam	TF350699
NextBio	20815334
PRO	PR:P28362
Proteomes	UP000000539
ExpressionAtlas	P28362
GO	GO:0005634 GO:0005667 GO:0000977 GO:0001227 GO:0003712 GO:0090427 GO:0009952 GO:0061312 GO:0060346 GO:0071392 GO:0071363 GO:0002063 GO:0035115 GO:0035116 GO:0035880 GO:0003416 GO:0003198 GO:0060364 GO:0043066 GO:0008285 GO:0032792 GO:0045599 GO:0045617 GO:2000678 GO:0002076 GO:0003148 GO:0030513 GO:0051795 GO:2001055 GO:0045669 GO:0023019 GO:0035313
Gene3D	1.10.10.60
InterPro	IPR017970 IPR001356 IPR020479 IPR009057
Pfam	PF00046
PRINTS	PR00024
SMART	SM00389
SUPFAM	SSF46689
PROSITE	PS00027 PS50071

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0048598	embryonic morphogenesis	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97168 MGI:MGI:97169 PANTHER:PTN000678062 UniProtKB:P28360 WB:WBGene00006881 ZFIN:ZDB-GENE-980526-26 ZFIN:ZDB-GENE-980526-306 ZFIN:ZDB-GENE-980526-312	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000492 MGI:MGI:106587 MGI:MGI:97168 PANTHER:PTN000678062 UniProtKB:P28360 UniProtKB:P35548 WB:WBGene00006881	C	Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97168 MGI:MGI:97169 PANTHER:PTN000678062 RGD:3116	F	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35548 ensembl:ENSP00000239243	F	Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35548 ensembl:ENSP00000239243	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35548 ensembl:ENSP00000239243	C	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35548 ensembl:ENSP00000239243	P	Seeded From UniProt	complete
involved_in	GO:2001055	positive regulation of mesenchymal cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
involved_in	GO:2000678	negative regulation of transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
involved_in	GO:0090427	activation of meiosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
involved_in	GO:0071392	cellular response to estradiol stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
involved_in	GO:0071363	cellular response to growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
involved_in	GO:0061312	BMP signaling pathway involved in heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
involved_in	GO:0060364	frontal suture morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
involved_in	GO:0060349	bone morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
involved_in	GO:0060346	bone trabecula formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
involved_in	GO:0051795	positive regulation of timing of catagen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
involved_in	GO:0051216	cartilage development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
involved_in	GO:0048863	stem cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
involved_in	GO:0045617	negative regulation of keratinocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
involved_in	GO:0045599	negative regulation of fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	F	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
involved_in	GO:0042733	embryonic digit morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
involved_in	GO:0035880	embryonic nail plate morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
involved_in	GO:0035313	wound healing, spreading of epidermal cells	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
involved_in	GO:0035116	embryonic hindlimb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
involved_in	GO:0035115	embryonic forelimb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
involved_in	GO:0032792	negative regulation of CREB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
involved_in	GO:0030513	positive regulation of BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
involved_in	GO:0030326	embryonic limb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
involved_in	GO:0023019	signal transduction involved in regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	F	Seeded From UniProt	complete
enables	GO:0003712	transcription coregulator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	F	Seeded From UniProt	complete
involved_in	GO:0003416	endochondral bone growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
involved_in	GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
involved_in	GO:0003151	outflow tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
involved_in	GO:0003148	outflow tract septum morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
involved_in	GO:0002076	osteoblast development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
involved_in	GO:0002063	chondrocyte development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
involved_in	GO:0001649	osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
involved_in	GO:0001503	ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	F	Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	F	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03358 ensembl:ENSMUSP00000021922	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001356 InterPro:IPR009057 InterPro:IPR020479	F	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0371 UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0001503	ossification	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0892	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[1]

CHICK:MSX2

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