CHICK:MMP2

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	MMP2
Protein Name(s)	72 kDa type IV collagenase 72 kDa gelatinase Gelatinase A Matrix metalloproteinase-2 MMP-2
External Links
UniProt	Q90611
EMBL	U07775
PIR	S46492
RefSeq	NP_989751.1
UniGene	Gga.3199
ProteinModelPortal	Q90611
SMR	Q90611
STRING	9031.ENSGALP00000005656
MEROPS	M10.003
PaxDb	Q90611
Ensembl	ENSGALT00000005666
GeneID	386583
KEGG	gga:386583
CTD	4313
eggNOG	NOG303159
GeneTree	ENSGT00760000119132
HOGENOM	HOG000217926
HOVERGEN	HBG052484
InParanoid	Q90611
KO	K01398
OMA	PCKFPFR
OrthoDB	EOG70KGNX
PhylomeDB	Q90611
TreeFam	TF315428
Reactome	REACT_197190 REACT_197191 REACT_197231 REACT_247929 REACT_257494
NextBio	20813946
PRO	PR:Q90611
Proteomes	UP000000539
GO	GO:0005615 GO:0005739 GO:0005886 GO:0005578 GO:0030017 GO:0004222 GO:0008270 GO:0001955 GO:0060346 GO:0071230 GO:0030574 GO:0060325 GO:0001957 GO:0045089 GO:0001666
Gene3D	2.10.10.10 2.110.10.10 3.40.390.10
InterPro	IPR028708 IPR000562 IPR000585 IPR018487 IPR018486 IPR013806 IPR024079 IPR001818 IPR021190 IPR021158 IPR006026 IPR002477
PANTHER	PTHR10201:SF29
Pfam	PF00040 PF00045 PF00413 PF01471
PRINTS	PR00138
SMART	SM00059 SM00120 SM00235
SUPFAM	SSF47090 SSF50923 SSF57440
PROSITE	PS00546 PS00023 PS51092 PS00024 PS51642 PS00142

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:1904932	negative regulation of cartilage condensation	PMID:17604018^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000134)	Seeded From UniProt	complete
involved_in	GO:1990314	cellular response to insulin-like growth factor stimulus	PMID:17604018^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000134)	Seeded From UniProt	complete
involved_in	GO:0043408	regulation of MAPK cascade	PMID:17604018^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000134)	Seeded From UniProt	complete
involved_in	GO:0051895	negative regulation of focal adhesion assembly	PMID:17604018^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000134)	Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation	PMID:17604018^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000134)	Seeded From UniProt	complete
involved_in	GO:0061037	negative regulation of cartilage development	PMID:17604018^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000134)	Seeded From UniProt	complete
enables	GO:0004222	metalloendopeptidase activity	PMID:17604018^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(CL:0000134)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:17604018^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005623	cell	PMID:10820319^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0009617)\|part_of:(UBERON:0002329)\|part_of:(UBERON:0004871)\|part_of:(UBERON:0003114)\|part_of:(UBERON:0003115)\|part_of:(UBERON:0005432)\|part_of:(UBERON:0003089)\|part_of:(UBERON:0004871)\|part_of:(UBERON:0006060)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:10820319^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0006060)\|part_of:(UBERON:0001041)\|part_of:(UBERON:0007005)	Seeded From UniProt	complete
part_of	GO:0005604	basement membrane	PMID:10820319^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0000924)\|part_of:(UBERON:0005062)\|part_of:(UBERON:0002328)\|part_of:(UBERON:0000925)\|part_of:(UBERON:0007005)	Seeded From UniProt	complete
enables	GO:0004222	metalloendopeptidase activity	PMID:10820319^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(UBERON:0002539)\|occurs_in:(UBERON:0000948)	Seeded From UniProt	complete
involved_in	GO:0051895	negative regulation of focal adhesion assembly	PMID:20828368^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0009749) occurs_in:(CL:0000134) happens_during:(GO:0051216)	Seeded From UniProt	complete
enables	GO:0004222	metalloendopeptidase activity	PMID:20828368^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(UBERON:0009749) occurs_in:(CL:0000134)	Seeded From UniProt	complete
involved_in	GO:0048771	tissue remodeling	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002565602 RGD:621316	P		Seeded From UniProt	complete
involved_in	GO:0030574	collagen catabolic process	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101900 MGI:MGI:1276107 MGI:MGI:1340026 MGI:MGI:97008 MGI:MGI:97009 MGI:MGI:97011 PANTHER:PTN001303987 RGD:621316 RGD:621320 UniProtKB:P45452	P		Seeded From UniProt	complete
involved_in	GO:0030198	extracellular matrix organization	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0033438 FB:FBgn0035049 MGI:MGI:1340026 MGI:MGI:1353466 MGI:MGI:97008 MGI:MGI:97011 PANTHER:PTN001303987 UniProtKB:P45452 WB:WBGene00006987 ZFIN:ZDB-GENE-040426-2132	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97005 MGI:MGI:97009 PANTHER:PTN000810753 RGD:3100 RGD:620196 RGD:621316 RGD:621317 RGD:621320 RGD:631408 UniProtKB:B5DFD5 UniProtKB:P02790 UniProtKB:P08253 UniProtKB:P14780 UniProtKB:P22894 UniProtKB:P39900 UniProtKB:P50281 UniProtKB:Q90611	C		Seeded From UniProt	complete
enables	GO:0004222	metalloendopeptidase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0033438 MGI:MGI:101900 MGI:MGI:1340026 MGI:MGI:1341867 MGI:MGI:97009 MGI:MGI:97011 PANTHER:PTN001303987 RGD:620196 TAIR:locus:2020548 TAIR:locus:2025891 TAIR:locus:2032467 TAIR:locus:2055605 TAIR:locus:2130928 UniProtKB:O60882 UniProtKB:O75900 UniProtKB:P03956 UniProtKB:P14780 UniProtKB:P39900 UniProtKB:P45452 UniProtKB:P51512 UniProtKB:Q90611 UniProtKB:Q99542	F		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97009 PANTHER:PTN002565602 RGD:621316	P		Seeded From UniProt	complete
involved_in	GO:1904707	positive regulation of vascular smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08253 ensembl:ENSP00000219070	P		Seeded From UniProt	complete
involved_in	GO:0035987	endodermal cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08253 ensembl:ENSP00000219070	P		Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08253 ensembl:ENSP00000219070	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08253 ensembl:ENSP00000219070	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08253 ensembl:ENSP00000219070	C		Seeded From UniProt	complete
involved_in	GO:0071230	cellular response to amino acid stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33434 ensembl:ENSMUSP00000034187	P		Seeded From UniProt	complete
involved_in	GO:0060346	bone trabecula formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33434 ensembl:ENSMUSP00000034187	P		Seeded From UniProt	complete
involved_in	GO:0060325	face morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33434 ensembl:ENSMUSP00000034187	P		Seeded From UniProt	complete
involved_in	GO:0048705	skeletal system morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33434 ensembl:ENSMUSP00000034187	P		Seeded From UniProt	complete
involved_in	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33434 ensembl:ENSMUSP00000034187	P		Seeded From UniProt	complete
involved_in	GO:0034614	cellular response to reactive oxygen species	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33434 ensembl:ENSMUSP00000034187	P		Seeded From UniProt	complete
involved_in	GO:0030574	collagen catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33434 ensembl:ENSMUSP00000034187	P		Seeded From UniProt	complete
part_of	GO:0030017	sarcomere	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33434 ensembl:ENSMUSP00000034187	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33434 ensembl:ENSMUSP00000034187	C		Seeded From UniProt	complete
enables	GO:0004222	metalloendopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33434 ensembl:ENSMUSP00000034187	F		Seeded From UniProt	complete
involved_in	GO:0001957	intramembranous ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33434 ensembl:ENSMUSP00000034187	P		Seeded From UniProt	complete
involved_in	GO:0001955	blood vessel maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33434 ensembl:ENSMUSP00000034187	P		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33434 ensembl:ENSMUSP00000034187	P		Seeded From UniProt	complete
enables	GO:0004222	metalloendopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001818 InterPro:IPR021158 InterPro:IPR021190 InterPro:IPR028708	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001818 InterPro:IPR006026 InterPro:IPR021158 InterPro:IPR021190 InterPro:IPR028708	P		Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006026 InterPro:IPR024079 InterPro:IPR033739	F		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001818 InterPro:IPR006026 InterPro:IPR021158 InterPro:IPR021190 InterPro:IPR033739	F		Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001818 InterPro:IPR021158 InterPro:IPR021190	C		Seeded From UniProt	complete
involved_in	GO:0030574	collagen catabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0177	P		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C		Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0482	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Jin, EJ et al. (2007) MMP-2 functions as a negative regulator of chondrogenic cell condensation via down-regulation of the FAK-integrin beta1 interaction. Dev. Biol. 308 474-84 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Cai, DH et al. (2000) MMP-2 expression during early avian cardiac and neural crest morphogenesis. Anat. Rec. 259 168-79 PubMed GONUTS page
↑ ^3.0 ^3.1 Song, J et al. (2011) MicroRNA-488 suppresses cell migration through modulation of the focal adhesion activity during chondrogenic differentiation of chick limb mesenchymal cells. Cell Biol. Int. 35 179-85 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17604018-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Jin, EJ et al. (2007) MMP-2 functions as a negative regulator of chondrogenic cell condensation via down-regulation of the FAK-integrin beta1 interaction. Dev. Biol. 308 474-84 PubMed GONUTS page

[PMID:10820319-2] 2.0 ^2.1 ^2.2 ^2.3 Cai, DH et al. (2000) MMP-2 expression during early avian cardiac and neural crest morphogenesis. Anat. Rec. 259 168-79 PubMed GONUTS page

[PMID:20828368-3] 3.0 ^3.1 Song, J et al. (2011) MicroRNA-488 suppresses cell migration through modulation of the focal adhesion activity during chondrogenic differentiation of chick limb mesenchymal cells. Cell Biol. Int. 35 179-85 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[1]

[2]

[3]

[4]

CHICK:MMP2

Contents

Annotations

Notes

References

a

b

c

d

e

f

g

h

i

m

n

o

p

r

s

t

v

z

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools