CHICK:IL8

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	CXCL8 (synonyms: CEF4, EMF1, IL8)
Protein Name(s)	Interleukin-8 IL-8 9E3 C-X-C motif chemokine 8 CEF-4 Chemokine (C-X-C motif) ligand 8 Embryo fibroblast protein 1 EMF-1
External Links
UniProt	P08317
EMBL	M16199 J02975 AJ009800
PIR	A26736 I50417
RefSeq	NP_990829.1
UniGene	Gga.826
ProteinModelPortal	P08317
PaxDb	P08317
Ensembl	ENSGALT00000042745
GeneID	396495
KEGG	gga:396495
CTD	396495
eggNOG	NOG73311
GeneTree	ENSGT00530000062901
HOGENOM	HOG000220915
HOVERGEN	HBG107789
InParanoid	P08317
KO	K10030
OMA	CEAAVLT
PhylomeDB	P08317
TreeFam	TF333433
Reactome	REACT_106504 REACT_214700 REACT_250082 REACT_253620
NextBio	20816534
Proteomes	UP000000539
GO	GO:0005615 GO:0005125 GO:0006955 GO:0042119 GO:0030593
InterPro	IPR001089 IPR018048 IPR001811 IPR028469
PANTHER	PTHR10179 PTHR10179:SF35
Pfam	PF00048
PRINTS	PR00437
SMART	SM00199
SUPFAM	SSF54117
PROSITE	PS00471

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0002548	monocyte chemotaxis	PMID:9878121^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0005335)	Seeded From UniProt	complete
involved_in	GO:0048247	lymphocyte chemotaxis	PMID:9878121^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0005335)	Seeded From UniProt	complete
involved_in	GO:0048246	macrophage chemotaxis	PMID:9878121^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0005335)	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:9878121^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0005335)	Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	PMID:11781340^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:11781340^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:F1NJ08) occurs_in:(CL:0000057)\|has_regulation_target(UniProtKB:P08023) occurs_in:(CL:0000057)	Seeded From UniProt	complete
involved_in	GO:0036446	myofibroblast differentiation	PMID:11781340^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048147	negative regulation of fibroblast proliferation	PMID:11781340^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:19776194^[3]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000021269 RGD:621812 RGD:70069 RGD:708540 UniProtKB:P02778 UniProtKB:P10145 UniProtKB:P80162 UniProtKB:P80221	P		Seeded From UniProt	complete
involved_in	GO:0070098	chemokine-mediated signaling pathway	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000021269 UniProtKB:O14625 UniProtKB:P02778	P		Seeded From UniProt	complete
involved_in	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1888711 PANTHER:PTN000021269 UniProtKB:P02776 UniProtKB:P80162 UniProtKB:P80221	P		Seeded From UniProt	complete
involved_in	GO:0030595	leukocyte chemotaxis	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000021269 RGD:70069 UniProtKB:P02776	P		Seeded From UniProt	complete
involved_in	GO:0030593	neutrophil chemotaxis	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1339941 MGI:MGI:3037818 PANTHER:PTN000021269 RGD:619869 RGD:621812 RGD:70069 UniProtKB:P10145 UniProtKB:P79255 UniProtKB:P80162 UniProtKB:P80221	P		Seeded From UniProt	complete
enables	GO:0008009	chemokine activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1339941 MGI:MGI:1888499 MGI:MGI:1888712 MGI:MGI:3037818 PANTHER:PTN000021269 RGD:619869 RGD:620209 RGD:621812 RGD:70069 RGD:708540 RGD:727827 UniProtKB:O14625 UniProtKB:O43927 UniProtKB:P02778 UniProtKB:P10145 UniProtKB:P80162 UniProtKB:P80221 UniProtKB:Q07325	F		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000021269 RGD:3305 RGD:620209 RGD:727827	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1339941 PANTHER:PTN000021269 RGD:621812 RGD:708540	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108068 MGI:MGI:1340094 MGI:MGI:1352449 MGI:MGI:1352450 MGI:MGI:1888499 PANTHER:PTN000021269 RGD:619869 RGD:620209 RGD:621812 RGD:70069 RGD:708540 UniProtKB:P19876	C		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
enables	GO:0005153	interleukin-8 receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028469	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001089 InterPro:IPR001811 InterPro:IPR018048 InterPro:IPR028469 InterPro:IPR036048	C		Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033899	P		Seeded From UniProt	complete
involved_in	GO:0006952	defense response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033899	P		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001089 InterPro:IPR001811 InterPro:IPR018048 InterPro:IPR036048	P		Seeded From UniProt	complete
enables	GO:0008009	chemokine activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001089 InterPro:IPR001811 InterPro:IPR018048 InterPro:IPR028469 InterPro:IPR033899 InterPro:IPR036048	F		Seeded From UniProt	complete
involved_in	GO:0030593	neutrophil chemotaxis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028469	P		Seeded From UniProt	complete
involved_in	GO:0042119	neutrophil activation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028469	P		Seeded From UniProt	complete
involved_in	GO:0050729	positive regulation of inflammatory response	PMID:16430960^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030595	leukocyte chemotaxis	PMID:16430960^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030097	hemopoiesis	PMID:16430960^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002269	leukocyte activation involved in inflammatory response	PMID:16430960^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002232	leukocyte chemotaxis involved in inflammatory response	PMID:16430960^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0145	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Martins-Green, M & Kelly, T (1998) The chicken chemotactic and angiogenic factor (9E3 gene product): its angiogenic properties reside in the C-terminus of the molecule. Cytokine 10 819-30 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Feugate, JE et al. (2002) The cxc chemokine cCAF stimulates differentiation of fibroblasts into myofibroblasts and accelerates wound closure. J. Cell Biol. 156 161-72 PubMed GONUTS page
↑ Lu, Y et al. (2009) Expression profiles of genes in Toll-like receptor-mediated signaling of broilers infected with Clostridium perfringens. Clin. Vaccine Immunol. 16 1639-47 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Bar-Shira, E & Friedman, A (2006) Development and adaptations of innate immunity in the gastrointestinal tract of the newly hatched chick. Dev. Comp. Immunol. 30 930-41 PubMed GONUTS page

[PMID:9878121-1] 1.0 ^1.1 ^1.2 ^1.3 Martins-Green, M & Kelly, T (1998) The chicken chemotactic and angiogenic factor (9E3 gene product): its angiogenic properties reside in the C-terminus of the molecule. Cytokine 10 819-30 PubMed GONUTS page

[PMID:11781340-2] 2.0 ^2.1 ^2.2 ^2.3 Feugate, JE et al. (2002) The cxc chemokine cCAF stimulates differentiation of fibroblasts into myofibroblasts and accelerates wound closure. J. Cell Biol. 156 161-72 PubMed GONUTS page

[PMID:19776194-3] Lu, Y et al. (2009) Expression profiles of genes in Toll-like receptor-mediated signaling of broilers infected with Clostridium perfringens. Clin. Vaccine Immunol. 16 1639-47 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16430960-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Bar-Shira, E & Friedman, A (2006) Development and adaptations of innate immunity in the gastrointestinal tract of the newly hatched chick. Dev. Comp. Immunol. 30 930-41 PubMed GONUTS page

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CHICK:IL8

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