CHICK:IL10

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	IL10 (ECO:0000312 with EMBL:CAF21727.1)
Protein Name(s)	Interleukin-10 IL-10
External Links
UniProt	Q6A2H4
EMBL	AJ621614 AJ621254 AY647438
RefSeq	NP_001004414.2
UniGene	Gga.46641
ProteinModelPortal	Q6A2H4
PaxDb	Q6A2H4
PRIDE	Q6A2H4
Ensembl	ENSGALT00000001312
GeneID	428264
KEGG	gga:428264
CTD	3586
eggNOG	NOG43085
GeneTree	ENSGT00510000048535
HOGENOM	HOG000072692
HOVERGEN	HBG004110
InParanoid	Q6A2H4
KO	K05443
OMA	PHMLREL
PhylomeDB	Q6A2H4
NextBio	20829305
PRO	PR:Q6A2H4
Proteomes	UP000000539
GO	GO:0005576 GO:0005615 GO:0042742 GO:0042832 GO:0006955 GO:0006954 GO:0030889 GO:0002875 GO:0002740 GO:0044130 GO:0045077 GO:0032695 GO:0032715 GO:0051045 GO:0030886 GO:0045019 GO:0002826 GO:0032720 GO:0002904 GO:0050715 GO:0045348 GO:0051091 GO:0045944 GO:0032800 GO:0051384 GO:0002237
Gene3D	1.20.1250.10
InterPro	IPR009079 IPR012351 IPR000098 IPR020443
PANTHER	PTHR11585
Pfam	PF00726
PRINTS	PR01294
SMART	SM00188
SUPFAM	SSF47266

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0045077	negative regulation of interferon-gamma biosynthetic process	PMID:15294985^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045019	negative regulation of nitric oxide biosynthetic process	PMID:15294985^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042832	defense response to protozoan	PMID:16996141^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042832	defense response to protozoan	PMID:17045659^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042832	defense response to protozoan	PMID:15294985^[1]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:15294985^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0002826	negative regulation of T-helper 1 type immune response	PMID:15294985^[1]	ECO:0000305	curator inference used in manual assertion	GO:0045077	P	Seeded From UniProt	complete
involved_in	GO:2000352	negative regulation of endothelial cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P	Seeded From UniProt	complete
involved_in	GO:1904706	negative regulation of vascular smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P	Seeded From UniProt	complete
involved_in	GO:1903672	positive regulation of sprouting angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P	Seeded From UniProt	complete
involved_in	GO:1903208	negative regulation of hydrogen peroxide-induced neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P	Seeded From UniProt	complete
involved_in	GO:1903034	regulation of response to wounding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P	Seeded From UniProt	complete
involved_in	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P	Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P	Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P	Seeded From UniProt	complete
involved_in	GO:0045787	positive regulation of cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P	Seeded From UniProt	complete
involved_in	GO:0045348	positive regulation of MHC class II biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P	Seeded From UniProt	complete
involved_in	GO:0044130	negative regulation of growth of symbiont in host	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P	Seeded From UniProt	complete
involved_in	GO:0042832	defense response to protozoan	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P	Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P	Seeded From UniProt	complete
involved_in	GO:0035729	cellular response to hepatocyte growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P	Seeded From UniProt	complete
involved_in	GO:0034115	negative regulation of heterotypic cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P	Seeded From UniProt	complete
involved_in	GO:0032720	negative regulation of tumor necrosis factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P	Seeded From UniProt	complete
involved_in	GO:0032695	negative regulation of interleukin-12 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P	Seeded From UniProt	complete
involved_in	GO:0032689	negative regulation of interferon-gamma production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P	Seeded From UniProt	complete
involved_in	GO:0030886	negative regulation of myeloid dendritic cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P	Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	C	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	F	Seeded From UniProt	complete
involved_in	GO:0002875	negative regulation of chronic inflammatory response to antigenic stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P	Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P	Seeded From UniProt	complete
involved_in	GO:0060302	negative regulation of cytokine activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22301 ensembl:ENSP00000412237	P	Seeded From UniProt	complete
involved_in	GO:0051384	response to glucocorticoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22301 ensembl:ENSP00000412237	P	Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22301 ensembl:ENSP00000412237	P	Seeded From UniProt	complete
involved_in	GO:0051045	negative regulation of membrane protein ectodomain proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22301 ensembl:ENSP00000412237	P	Seeded From UniProt	complete
involved_in	GO:0050715	positive regulation of cytokine secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22301 ensembl:ENSP00000412237	P	Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22301 ensembl:ENSP00000412237	F	Seeded From UniProt	complete
involved_in	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22301 ensembl:ENSP00000412237	P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22301 ensembl:ENSP00000412237	P	Seeded From UniProt	complete
involved_in	GO:0045347	negative regulation of MHC class II biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22301 ensembl:ENSP00000412237	P	Seeded From UniProt	complete
involved_in	GO:0032800	receptor biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22301 ensembl:ENSP00000412237	P	Seeded From UniProt	complete
involved_in	GO:0032715	negative regulation of interleukin-6 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22301 ensembl:ENSP00000412237	P	Seeded From UniProt	complete
involved_in	GO:0030889	negative regulation of B cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22301 ensembl:ENSP00000412237	P	Seeded From UniProt	complete
involved_in	GO:0010507	negative regulation of autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22301 ensembl:ENSP00000412237	P	Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22301 ensembl:ENSP00000412237	P	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22301 ensembl:ENSP00000412237	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22301 ensembl:ENSP00000412237	C	Seeded From UniProt	complete
involved_in	GO:0002904	positive regulation of B cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22301 ensembl:ENSP00000412237	P	Seeded From UniProt	complete
involved_in	GO:0002740	negative regulation of cytokine secretion involved in immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22301 ensembl:ENSP00000412237	P	Seeded From UniProt	complete
involved_in	GO:0002237	response to molecule of bacterial origin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22301 ensembl:ENSP00000412237	P	Seeded From UniProt	complete
involved_in	GO:0001818	negative regulation of cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22301 ensembl:ENSP00000412237	P	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000098	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000098	C	Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000098	P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Rothwell, L et al. (2004) Cloning and characterization of chicken IL-10 and its role in the immune response to Eimeria maxima. J. Immunol. 173 2675-82 PubMed GONUTS page
↑ Hong, YH et al. (2006) Analysis of chicken cytokine and chemokine gene expression following Eimeria acervulina and Eimeria tenella infections. Vet. Immunol. Immunopathol. 114 209-23 PubMed GONUTS page
↑ Hong, YH et al. (2006) Changes in immune-related gene expression and intestinal lymphocyte subpopulations following Eimeria maxima infection of chickens. Vet. Immunol. Immunopathol. 114 259-72 PubMed GONUTS page

[PMID:15294985-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Rothwell, L et al. (2004) Cloning and characterization of chicken IL-10 and its role in the immune response to Eimeria maxima. J. Immunol. 173 2675-82 PubMed GONUTS page

[PMID:16996141-2] Hong, YH et al. (2006) Analysis of chicken cytokine and chemokine gene expression following Eimeria acervulina and Eimeria tenella infections. Vet. Immunol. Immunopathol. 114 209-23 PubMed GONUTS page

[PMID:17045659-3] Hong, YH et al. (2006) Changes in immune-related gene expression and intestinal lymphocyte subpopulations following Eimeria maxima infection of chickens. Vet. Immunol. Immunopathol. 114 259-72 PubMed GONUTS page

[1]

[2]

[3]

CHICK:IL10

Contents

Annotations

Notes

References

a

c

d

e

g

i

m

n

o

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools