CHICK:HSP7C

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	HSPA8 (synonyms: HSC70)
Protein Name(s)	Heat shock cognate 71 kDa protein Heat shock 70 kDa protein 8
External Links
UniProt	O73885
EMBL	AJ004940
RefSeq	NP_990334.1
UniGene	Gga.4555
ProteinModelPortal	O73885
SMR	O73885
BioGrid	676126
IntAct	O73885
STRING	9031.ENSGALP00000040138
PaxDb	O73885
PRIDE	O73885
GeneID	395853
KEGG	gga:395853
CTD	3312
eggNOG	COG0443
HOGENOM	HOG000228135
HOVERGEN	HBG051845
InParanoid	O73885
KO	K03283
PhylomeDB	O73885
NextBio	20815920
PRO	PR:O73885
Proteomes	UP000000539
GO	GO:0005737 GO:0030529 GO:0005524 GO:0061024 GO:0006892
Gene3D	1.20.1270.10 2.60.34.10
InterPro	IPR018181 IPR029048 IPR029047 IPR013126
Pfam	PF00012
PRINTS	PR00301
SUPFAM	SSF100920 SSF100934
PROSITE	PS00297 PS00329 PS01036

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005737	cytoplasm	PMID:21707973^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21707973^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	UniProtKB:Q91N81	C		Seeded From UniProt	complete
enables	GO:0051219	phosphoprotein binding	PMID:8423808^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:A0A1D5P4K6 UniProtKB:Q9PSQ5	F	occurs_in:(UBERON:0000955)\|occurs_in:(UBERON:0002107)\|occurs_in:(UBERON:0000993) occurs_in:(GO:0005829)	Seeded From UniProt	complete
involved_in	GO:0007369	gastrulation	PMID:9707581^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048568	embryonic organ development	PMID:9707581^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009792	embryo development ending in birth or egg hatching	PMID:9707581^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:1990904	ribonucleoprotein complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11142	C		Seeded From UniProt	complete
enables	GO:1990833	clathrin-uncoating ATPase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002321717 RGD:621725	F		Seeded From UniProt	complete
involved_in	GO:1990832	slow axonal transport	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002321717 RGD:621725	P		Seeded From UniProt	complete
involved_in	GO:1904764	chaperone-mediated autophagy translocation complex disassembly	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002321717 RGD:621725	P		Seeded From UniProt	complete
part_of	GO:0099524	postsynaptic cytosol	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002321717 RGD:621725	C		Seeded From UniProt	complete
part_of	GO:0099523	presynaptic cytosol	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002321717 RGD:621725	C		Seeded From UniProt	complete
involved_in	GO:0061741	chaperone-mediated protein transport involved in chaperone-mediated autophagy	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002321717 RGD:621725	P		Seeded From UniProt	complete
involved_in	GO:0061740	protein targeting to lysosome involved in chaperone-mediated autophagy	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002321717 UniProtKB:P11142	P		Seeded From UniProt	complete
involved_in	GO:0061738	late endosomal microautophagy	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:105384 PANTHER:PTN002321717	P		Seeded From UniProt	complete
enables	GO:0051787	misfolded protein binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95835 PANTHER:PTN002321897 RGD:2843 UniProtKB:P11021	F		Seeded From UniProt	complete
involved_in	GO:0051085	chaperone cofactor-dependent protein refolding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10241 MGI:MGI:105384 PANTHER:PTN002321897	P		Seeded From UniProt	complete
enables	GO:0051082	unfolded protein binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10241 MGI:MGI:105384 PANTHER:PTN002321897 RGD:2843 RGD:621725 SGD:S000000004 SGD:S000000171 SGD:S000000905 SGD:S000001106 SGD:S000001556 SGD:S000002388 SGD:S000003571 SGD:S000003947 SGD:S000005153 UniProtKB:P0DMV8 UniProtKB:P0DMV9 UniProtKB:P11142 UniProtKB:P17066 UniProtKB:P34931 UniProtKB:P54652	F		Seeded From UniProt	complete
enables	GO:0044183	protein folding chaperone	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10241 PANTHER:PTN002321897 UniProtKB:P0DMV8 UniProtKB:P0DMV9	F		Seeded From UniProt	complete
part_of	GO:0043195	terminal bouton	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002321717 RGD:621725	C		Seeded From UniProt	complete
enables	GO:0042623	ATPase activity, coupled	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:105384 PANTHER:PTN002321897 RGD:621725 UniProtKB:P0DMV8 UniProtKB:P0DMV9 UniProtKB:P17066	F		Seeded From UniProt	complete
involved_in	GO:0042026	protein refolding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002321897 SGD:S000000004 SGD:S000000756 SGD:S000003806 UniProtKB:P0DMV8 UniProtKB:P0DMV9 UniProtKB:P11142 UniProtKB:P17066 UniProtKB:P34931 UniProtKB:P54652	P		Seeded From UniProt	complete
involved_in	GO:0034620	cellular response to unfolded protein	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10241 PANTHER:PTN002321897 UniProtKB:P0DMV8	P		Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000184706 PANTHER:PTN002321897 RGD:621725 SGD:S000000905 UniProtKB:A5I640 UniProtKB:P0DMV8 UniProtKB:P0DMV9 UniProtKB:P17066	P		Seeded From UniProt	complete
enables	GO:0031072	heat shock protein binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002321897 RGD:1311806 UniProtKB:K7NTP5 UniProtKB:O73885 UniProtKB:P0DMV8 UniProtKB:P0DMV9 UniProtKB:P11142 UniProtKB:P17066 UniProtKB:P34931 UniProtKB:Q8IB24	F		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002321717 RGD:621725	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002321717 RGD:621725	C		Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10241 EcoGene:EG12130 EcoGene:EG13653 PANTHER:PTN002321897 PomBase:SPAC664.11 RGD:621725 SGD:S000000004 SGD:S000000171 SGD:S000002388 SGD:S000003571 SGD:S000003806 SGD:S000005153 UniProtKB:P0DMV8 UniProtKB:P0DMV9 UniProtKB:P11021 UniProtKB:P11142 WB:WBGene00002005	F		Seeded From UniProt	complete
involved_in	GO:0016192	vesicle-mediated transport	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0266599 PANTHER:PTN002500132	P		Seeded From UniProt	complete
involved_in	GO:0008088	axo-dendritic transport	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002321717 RGD:621725	P		Seeded From UniProt	complete
involved_in	GO:0006986	response to unfolded protein	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002321897 RGD:1593284 RGD:2840 SGD:S000001556 SGD:S000003571 UniProtKB:P0DMV8	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000184853 PANTHER:PTN002500132	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000184706 MGI:MGI:105384 PANTHER:PTN002500132 RGD:621725 SGD:S000000171 SGD:S000003947 UniProtKB:P08106 UniProtKB:P11142 UniProtKB:P54652 UniProtKB:Q7SX63 WB:WBGene00002005	C		Seeded From UniProt	complete
part_of	GO:0005776	autophagosome	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002321717 RGD:621725	C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002321717 RGD:621725	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10241 FB:FBgn0266599 MGI:MGI:105384 MGI:MGI:96244 PANTHER:PTN002321897 PomBase:SPCC1739.13 RGD:1311806 RGD:2843 RGD:621725 SGD:S000000004 SGD:S000000905 SGD:S000001106 SGD:S000002388 SGD:S000003947 UniProtKB:O73885 UniProtKB:P08106 UniProtKB:P0DMV8 UniProtKB:P0DMV9 UniProtKB:P17066 UniProtKB:P22953 UniProtKB:Q27975 UniProtKB:Q8IB24 WB:WBGene00002005	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0266599 PANTHER:PTN002500132 PomBase:SPCC1739.13 RGD:621725 SGD:S000000004 SGD:S000000905 UniProtKB:O73885 UniProtKB:P08106 UniProtKB:P11142 UniProtKB:Q7SX63 WB:WBGene00002005	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10241 EcoGene:EG12130 PANTHER:PTN002321897 RGD:621725 SGD:S000001556 SGD:S000003947 TAIR:locus:2101222 TAIR:locus:2121022 TAIR:locus:2135897 TAIR:locus:2144801 UniProtKB:P08106 UniProtKB:P0DMV8 UniProtKB:P0DMV9 UniProtKB:P11142 UniProtKB:Q7SX63	F		Seeded From UniProt	complete
involved_in	GO:0072318	clathrin coat disassembly	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:1990833	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Chen, K et al. (2011) Gallus Heat shock cognate protein 70, a novel binding partner of Apoptin. Virol. J. 8 324 PubMed GONUTS page
↑ Smith, DF et al. (1993) Identification of a 60-kilodalton stress-related protein, p60, which interacts with hsp90 and hsp70. Mol. Cell. Biol. 13 869-76 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 de la Rosa, EJ et al. (1998) Modulation of the chaperone heat shock cognate 70 by embryonic (pro)insulin correlates with prevention of apoptosis. Proc. Natl. Acad. Sci. U.S.A. 95 9950-5 PubMed GONUTS page
↑ ^4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 ^4.14 ^4.15 ^4.16 ^4.17 ^4.18 ^4.19 ^4.20 ^4.21 ^4.22 ^4.23 ^4.24 ^4.25 ^4.26 ^4.27 ^4.28 ^4.29 ^4.30 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21707973-1] 1.0 ^1.1 Chen, K et al. (2011) Gallus Heat shock cognate protein 70, a novel binding partner of Apoptin. Virol. J. 8 324 PubMed GONUTS page

[PMID:8423808-2] Smith, DF et al. (1993) Identification of a 60-kilodalton stress-related protein, p60, which interacts with hsp90 and hsp70. Mol. Cell. Biol. 13 869-76 PubMed GONUTS page

[PMID:9707581-3] 3.0 ^3.1 ^3.2 de la Rosa, EJ et al. (1998) Modulation of the chaperone heat shock cognate 70 by embryonic (pro)insulin correlates with prevention of apoptosis. Proc. Natl. Acad. Sci. U.S.A. 95 9950-5 PubMed GONUTS page

[PMID:21873635-4] 4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 ^4.14 ^4.15 ^4.16 ^4.17 ^4.18 ^4.19 ^4.20 ^4.21 ^4.22 ^4.23 ^4.24 ^4.25 ^4.26 ^4.27 ^4.28 ^4.29 ^4.30 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CHICK:HSP7C

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