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CHICK:HES1

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) HES1 (synonyms: HAIRY1)
Protein Name(s) Transcription factor HES-1

C-HAIRY1 Hairy and enhancer of split 1

External Links
UniProt O57337
EMBL AF032966
UniGene Gga.3754
Gga.51069
ProteinModelPortal O57337
PaxDb O57337
eggNOG NOG319418
HOGENOM HOG000236346
HOVERGEN HBG005960
InParanoid O57337
PhylomeDB O57337
NextBio 20815220
PRO PR:O57337
Proteomes UP000000539
GO GO:0005634
GO:0003677
GO:0006355
GO:0006351
Gene3D 4.10.280.10
InterPro IPR011598
IPR003650
Pfam PF07527
PF00010
SMART SM00353
SM00511
SUPFAM SSF47459
PROSITE PS50888
PS51054

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0045665

negative regulation of neuron differentiation

PMID:17681138[1]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:1990837

sequence-specific double-stranded DNA binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0002609
FB:FBgn0002633
FB:FBgn0002733
FB:FBgn0002734
FB:FBgn0002735
FB:FBgn0010109
PANTHER:PTN000105427

F

Seeded From UniProt

complete

involved_in

GO:0050767

regulation of neurogenesis

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104853
MGI:MGI:104876
MGI:MGI:104877
PANTHER:PTN000105428
ZFIN:ZDB-GENE-980526-144

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000591
FB:FBgn0002609
FB:FBgn0002631
FB:FBgn0002633
FB:FBgn0002733
FB:FBgn0002734
FB:FBgn0002735
FB:FBgn0010109
MGI:MGI:1341800
MGI:MGI:1341884
MGI:MGI:1860511
PANTHER:PTN000105427
RGD:62081
SGD:S000001930
UniProtKB:Q9UBP5

F

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1859852
PANTHER:PTN000105428

P

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0001168
FB:FBgn0002633
FB:FBgn0002735
MGI:MGI:1341884
PANTHER:PTN000105427
RGD:62081

F

Seeded From UniProt

complete

involved_in

GO:0007219

Notch signaling pathway

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0010109
MGI:MGI:104853
MGI:MGI:104876
MGI:MGI:1341800
MGI:MGI:1341884
MGI:MGI:2135679
PANTHER:PTN000105428
RGD:621403
RGD:621405
UniProtKB:Q14469
UniProtKB:Q5TA89
UniProtKB:Q9NQ87
UniProtKB:Q9Y5J3

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0002631
FB:FBgn0002733
FB:FBgn0002735
FB:FBgn0010109
FB:FBgn0027788
FB:FBgn0259938
MGI:MGI:104853
MGI:MGI:1097714
MGI:MGI:1341800
MGI:MGI:1341884
MGI:MGI:3040955
PANTHER:PTN000105427
RGD:621403
RGD:621405
RGD:68439
SGD:S000001930
UniProtKB:O14503
UniProtKB:Q14469
UniProtKB:Q9NQ87

C

Seeded From UniProt

complete

enables

GO:0003714

transcription corepressor activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1097714
MGI:MGI:1860511
MGI:MGI:1930704
PANTHER:PTN000105427
UniProtKB:O14503
UniProtKB:Q9C0J9
UniProtKB:Q9NQ87

F

Seeded From UniProt

complete

involved_in

GO:0001756

somitogenesis

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2135679
PANTHER:PTN000105429
ZFIN:ZDB-GENE-030707-2
ZFIN:ZDB-GENE-040824-5
ZFIN:ZDB-GENE-980526-125

P

Seeded From UniProt

complete

enables

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1859852
MGI:MGI:2135679
PANTHER:PTN000105427

F

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:11076679[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:11076679[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:1903507

negative regulation of nucleic acid-templated transcription

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0003714

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003650

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003650

P

Seeded From UniProt

complete

enables

GO:0046983

protein dimerization activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011598
InterPro:IPR036638

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Bai, G et al. (2007) Id sustains Hes1 expression to inhibit precocious neurogenesis by releasing negative autoregulation of Hes1. Dev. Cell 13 283-97 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. 3.0 3.1 Leimeister, C et al. (2000) Oscillating expression of c-Hey2 in the presomitic mesoderm suggests that the segmentation clock may use combinatorial signaling through multiple interacting bHLH factors. Dev. Biol. 227 91-103 PubMed GONUTS page