CHICK:GRP78

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	HSPA5 (synonyms: GRP78)
Protein Name(s)	78 kDa glucose-regulated protein GRP-78 Heat shock 70 kDa protein 5 Immunoglobulin heavy chain-binding protein BiP
External Links
UniProt	Q90593
EMBL	M27260
PIR	I50242
RefSeq	NP_990822.1
UniGene	Gga.4219
ProteinModelPortal	Q90593
SMR	Q90593
BioGrid	676734
IntAct	Q90593
STRING	9031.ENSGALP00000001474
PaxDb	Q90593
PRIDE	Q90593
Ensembl	ENSGALT00000001476
GeneID	396487
KEGG	gga:396487
CTD	3309
eggNOG	COG0443
GeneTree	ENSGT00750000117237
HOGENOM	HOG000228135
HOVERGEN	HBG051845
InParanoid	Q90593
KO	K09490
OMA	NQDTEPE
OrthoDB	EOG780RKX
PhylomeDB	Q90593
TreeFam	TF105044
Reactome	REACT_288861
NextBio	20816526
PRO	PR:Q90593
Proteomes	UP000000539
GO	GO:0009986 GO:0008180 GO:0034663 GO:0005788 GO:0005793 GO:0070062 GO:0005925 GO:0030176 GO:0030496 GO:0043209 GO:0005886 GO:0005524 GO:0043022 GO:0006987 GO:0042149 GO:0071353 GO:0021680 GO:0021589 GO:0006983 GO:0035437 GO:0043066 GO:0030512 GO:0030335 GO:0031398 GO:0051603 GO:0021762 GO:1901998
Gene3D	1.20.1270.10 2.60.34.10
InterPro	IPR018181 IPR029048 IPR029047 IPR013126
Pfam	PF00012
PRINTS	PR00301
SUPFAM	SSF100920 SSF100934
PROSITE	PS00014 PS00297 PS00329 PS01036

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0016887	ATPase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:G3I8R9	F	Seeded From UniProt	complete
involved_in	GO:1903895	negative regulation of IRE1-mediated unfolded protein response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:G3I8R9	P	Seeded From UniProt	complete
involved_in	GO:0090074	negative regulation of protein homodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:G3I8R9	P	Seeded From UniProt	complete
enables	GO:0051787	misfolded protein binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95835 PANTHER:PTN002321897 RGD:2843 UniProtKB:P11021	F	Seeded From UniProt	complete
involved_in	GO:0051085	chaperone cofactor-dependent protein refolding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10241 MGI:MGI:105384 PANTHER:PTN002321897	P	Seeded From UniProt	complete
enables	GO:0051082	unfolded protein binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10241 MGI:MGI:105384 PANTHER:PTN002321897 RGD:2843 RGD:621725 SGD:S000000004 SGD:S000000171 SGD:S000000905 SGD:S000001106 SGD:S000001556 SGD:S000002388 SGD:S000003571 SGD:S000003947 SGD:S000005153 UniProtKB:P0DMV8 UniProtKB:P0DMV9 UniProtKB:P11142 UniProtKB:P17066 UniProtKB:P34931 UniProtKB:P54652	F	Seeded From UniProt	complete
enables	GO:0044183	protein folding chaperone	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10241 PANTHER:PTN002321897 UniProtKB:P0DMV8 UniProtKB:P0DMV9	F	Seeded From UniProt	complete
enables	GO:0042623	ATPase activity, coupled	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:105384 PANTHER:PTN002321897 RGD:621725 UniProtKB:P0DMV8 UniProtKB:P0DMV9 UniProtKB:P17066	F	Seeded From UniProt	complete
involved_in	GO:0042026	protein refolding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002321897 SGD:S000000004 SGD:S000000756 SGD:S000003806 UniProtKB:P0DMV8 UniProtKB:P0DMV9 UniProtKB:P11142 UniProtKB:P17066 UniProtKB:P34931 UniProtKB:P54652	P	Seeded From UniProt	complete
part_of	GO:0034663	endoplasmic reticulum chaperone complex	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95835 PANTHER:PTN001834223 UniProtKB:P11021	C	Seeded From UniProt	complete
involved_in	GO:0034620	cellular response to unfolded protein	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10241 PANTHER:PTN002321897 UniProtKB:P0DMV8	P	Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000184706 PANTHER:PTN002321897 RGD:621725 SGD:S000000905 UniProtKB:A5I640 UniProtKB:P0DMV8 UniProtKB:P0DMV9 UniProtKB:P17066	P	Seeded From UniProt	complete
enables	GO:0031072	heat shock protein binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002321897 RGD:1311806 UniProtKB:K7NTP5 UniProtKB:O73885 UniProtKB:P0DMV8 UniProtKB:P0DMV9 UniProtKB:P11142 UniProtKB:P17066 UniProtKB:P34931 UniProtKB:Q8IB24	F	Seeded From UniProt	complete
involved_in	GO:0030968	endoplasmic reticulum unfolded protein response	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95835 PANTHER:PTN001834223 WB:WBGene00002007 WB:WBGene00002008	P	Seeded From UniProt	complete
involved_in	GO:0030433	ubiquitin-dependent ERAD pathway	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001834223 SGD:S000003571 TAIR:locus:2182783	P	Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10241 EcoGene:EG12130 EcoGene:EG13653 PANTHER:PTN002321897 PomBase:SPAC664.11 RGD:621725 SGD:S000000004 SGD:S000000171 SGD:S000002388 SGD:S000003571 SGD:S000003806 SGD:S000005153 UniProtKB:P0DMV8 UniProtKB:P0DMV9 UniProtKB:P11021 UniProtKB:P11142 WB:WBGene00002005	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001834223 RGD:2843 UniProtKB:Q39043	C	Seeded From UniProt	complete
involved_in	GO:0006986	response to unfolded protein	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002321897 RGD:1593284 RGD:2840 SGD:S000001556 SGD:S000003571 UniProtKB:P0DMV8	P	Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95835 PANTHER:PTN001834223 PomBase:SPAC22A12.15c UniProtKB:Q6Z7B0	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10241 FB:FBgn0266599 MGI:MGI:105384 MGI:MGI:96244 PANTHER:PTN002321897 PomBase:SPCC1739.13 RGD:1311806 RGD:2843 RGD:621725 SGD:S000000004 SGD:S000000905 SGD:S000001106 SGD:S000002388 SGD:S000003947 UniProtKB:O73885 UniProtKB:P08106 UniProtKB:P0DMV8 UniProtKB:P0DMV9 UniProtKB:P17066 UniProtKB:P22953 UniProtKB:Q27975 UniProtKB:Q8IB24 WB:WBGene00002005	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001834223 UniProtKB:P11021 UniProtKB:Q39043	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10241 EcoGene:EG12130 PANTHER:PTN002321897 RGD:621725 SGD:S000001556 SGD:S000003947 TAIR:locus:2101222 TAIR:locus:2121022 TAIR:locus:2135897 TAIR:locus:2144801 UniProtKB:P08106 UniProtKB:P0DMV8 UniProtKB:P0DMV9 UniProtKB:P11142 UniProtKB:Q7SX63	F	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C	Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0096	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 ^1.17 ^1.18 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21873635-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 ^1.17 ^1.18 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CHICK:GRP78

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