CHICK:EXFAB

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	EXFABP
Protein Name(s)	Extracellular fatty acid-binding protein Ex-FABP Protein Ch21 Quiescence-specific protein p20K
External Links
UniProt	P21760
EMBL	M25784 M55644 AF121346 AY545055 X61199
PIR	A30230
RefSeq	NP_990753.1
UniGene	Gga.739
PDB	3SAO
PDBsum	3SAO
ProteinModelPortal	P21760
SMR	P21760
GeneID	396393
KEGG	gga:396393
CTD	138307
HOVERGEN	HBG096019
InParanoid	P21760
PhylomeDB	P21760
NextBio	20816435
PRO	PR:P21760
Proteomes	UP000000539
GO	GO:0005615 GO:0050544 GO:0015245 GO:0070539 GO:0070538 GO:0070540 GO:0006953 GO:0044255 GO:0042742 GO:0009792 GO:0055089 GO:0015908 GO:0007507 GO:0006954 GO:0045087 GO:0048747 GO:0043066 GO:0008284 GO:0032332 GO:0045663 GO:0010831 GO:0034097 GO:0042493 GO:0070543 GO:0032496 GO:0009636
Gene3D	2.40.128.20
InterPro	IPR012674 IPR011038 IPR002345 IPR022272 IPR000566 IPR002972
Pfam	PF00061
PRINTS	PR00179 PR01254
SUPFAM	SSF50814
PROSITE	PS00213

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0015908	fatty acid transport	PMID:15455366^[1]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006953	acute-phase response	PMID:15455366^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:15455366^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005504	fatty acid binding	PMID:15455366^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0015908	fatty acid transport	PMID:15455366^[1]	ECO:0000305	curator inference used in manual assertion	GO:0055089	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:12479589^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005504	fatty acid binding	PMID:12479589^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005504	fatty acid binding	PMID:8702740^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:10777107^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002062	chondrocyte differentiation	PMID:1737754^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:1737754^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:12891703^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:12891703^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:12891703^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	PMID:12891703^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:12891703^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	PMID:12891703^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:12891703^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071399	cellular response to linoleic acid	PMID:10409760^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	happens_during:(GO:0060242)	Seeded From UniProt	complete
involved_in	GO:0003415	chondrocyte hypertrophy	PMID:1737754^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005623	cell	PMID:9683528^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002372)\|part_of:(CL:0000187)\|part_of:(UBERON:0002349)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:9683528^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051412	response to corticosterone	PMID:25436390^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0008944)	Seeded From UniProt	complete
involved_in	GO:0070543	response to linoleic acid	PMID:12479589^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070540	stearic acid binding	PMID:8702740^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0070540	stearic acid binding	PMID:12479589^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0070539	linoleic acid binding	PMID:15455366^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0070539	linoleic acid binding	PMID:8702740^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0070539	linoleic acid binding	PMID:12479589^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0070538	oleic acid binding	PMID:8702740^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0070538	oleic acid binding	PMID:12479589^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0055089	fatty acid homeostasis	PMID:15455366^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050544	arachidonic acid binding	PMID:12479589^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0050544	arachidonic acid binding	PMID:8702740^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045663	positive regulation of myoblast differentiation	PMID:9683528^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044255	cellular lipid metabolic process	PMID:15455366^[1]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:12891703^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000056)	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:15455366^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:12479589^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034097	response to cytokine	PMID:10777107^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	PMID:10777107^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	PMID:12891703^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P	occurs_in:(UBERON:0002107)\|occurs_in:(CL:0000138)	Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	PMID:12479589^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	PMID:15455366^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032332	positive regulation of chondrocyte differentiation	PMID:12891703^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0015908	fatty acid transport	PMID:15455366^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010831	positive regulation of myotube differentiation	PMID:12891703^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:12891703^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000138)	Seeded From UniProt	complete
involved_in	GO:0007507	heart development	PMID:15455366^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:12479589^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:15455366^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006953	acute-phase response	PMID:10777107^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006953	acute-phase response	PMID:12891703^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:10777107^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:8702740^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:12891703^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:12479589^[2]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0036094	small molecule binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002345	F		Seeded From UniProt	complete
involved_in	GO:0015909	long-chain fatty acid transport	PMID:12479589^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	PMID:12891703^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:12891703^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0048747	muscle fiber development	PMID:12891703^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009792	embryo development ending in birth or egg hatching	PMID:12479589^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009636	response to toxic substance	PMID:12891703^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006953	acute-phase response	PMID:15455366^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0044	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 Gentili, C et al. (2005) Acute phase lipocalin Ex-FABP is involved in heart development and cell survival. J. Cell. Physiol. 202 683-9 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 Descalzi Cancedda, F et al. (2002) Ex-FABP, extracellular fatty acid binding protein, is a stress lipocalin expressed during chicken embryo development. Mol. Cell. Biochem. 239 221-5 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Cancedda, FD et al. (1996) The developmentally regulated avian Ch21 lipocalin is an extracellular fatty acid-binding protein. J. Biol. Chem. 271 20163-9 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Cermelli, S et al. (2000) Extracellular fatty acid binding protein (Ex-FABP) modulation by inflammatory agents: "physiological" acute phase response in endochondral bone formation. Eur. J. Cell Biol. 79 155-64 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Dozin, B et al. (1992) Expression, regulation, and tissue distribution of the Ch21 protein during chicken embryogenesis. J. Biol. Chem. 267 2979-85 PubMed GONUTS page
↑ ^6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 ^6.12 ^6.13 ^6.14 ^6.15 ^6.16 ^6.17 Di Marco, E et al. (2003) Inhibition of cell proliferation and induction of apoptosis by ExFABP gene targeting. J. Cell. Physiol. 196 464-73 PubMed GONUTS page
↑ Kim, S et al. (1999) C/EBPbeta (NF-M) is essential for activation of the p20K lipocalin gene in growth-arrested chicken embryo fibroblasts. Mol. Cell. Biol. 19 5718-31 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Gentili, C et al. (1998) Expression of the extracellular fatty acid binding protein (Ex-FABP) during muscle fiber formation in vivo and in vitro. Exp. Cell Res. 242 410-8 PubMed GONUTS page
↑ Kim, J & Choi, YH (2014) Differential abundance of egg white proteins in laying hens treated with corticosterone. J. Agric. Food Chem. 62 12346-59 PubMed GONUTS page

[PMID:15455366-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 Gentili, C et al. (2005) Acute phase lipocalin Ex-FABP is involved in heart development and cell survival. J. Cell. Physiol. 202 683-9 PubMed GONUTS page

[PMID:12479589-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 Descalzi Cancedda, F et al. (2002) Ex-FABP, extracellular fatty acid binding protein, is a stress lipocalin expressed during chicken embryo development. Mol. Cell. Biochem. 239 221-5 PubMed GONUTS page

[PMID:8702740-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Cancedda, FD et al. (1996) The developmentally regulated avian Ch21 lipocalin is an extracellular fatty acid-binding protein. J. Biol. Chem. 271 20163-9 PubMed GONUTS page

[PMID:10777107-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Cermelli, S et al. (2000) Extracellular fatty acid binding protein (Ex-FABP) modulation by inflammatory agents: "physiological" acute phase response in endochondral bone formation. Eur. J. Cell Biol. 79 155-64 PubMed GONUTS page

[PMID:1737754-5] 5.0 ^5.1 ^5.2 Dozin, B et al. (1992) Expression, regulation, and tissue distribution of the Ch21 protein during chicken embryogenesis. J. Biol. Chem. 267 2979-85 PubMed GONUTS page

[PMID:12891703-6] 6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 ^6.12 ^6.13 ^6.14 ^6.15 ^6.16 ^6.17 Di Marco, E et al. (2003) Inhibition of cell proliferation and induction of apoptosis by ExFABP gene targeting. J. Cell. Physiol. 196 464-73 PubMed GONUTS page

[PMID:10409760-7] Kim, S et al. (1999) C/EBPbeta (NF-M) is essential for activation of the p20K lipocalin gene in growth-arrested chicken embryo fibroblasts. Mol. Cell. Biol. 19 5718-31 PubMed GONUTS page

[PMID:9683528-8] 8.0 ^8.1 ^8.2 Gentili, C et al. (1998) Expression of the extracellular fatty acid binding protein (Ex-FABP) during muscle fiber formation in vivo and in vitro. Exp. Cell Res. 242 410-8 PubMed GONUTS page

[PMID:25436390-9] Kim, J & Choi, YH (2014) Differential abundance of egg white proteins in laying hens treated with corticosterone. J. Agric. Food Chem. 62 12346-59 PubMed GONUTS page

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CHICK:EXFAB

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