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CHICK:DNAS1

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) DNASE1
Protein Name(s) Deoxyribonuclease-1

Deoxyribonuclease I DNase I

External Links
UniProt Q9YGI5
EMBL AJ131751
RefSeq NP_996840.1
UniGene Gga.287
ProteinModelPortal Q9YGI5
SMR Q9YGI5
GeneID 395725
KEGG gga:395725
CTD 1773
eggNOG NOG46375
HOVERGEN HBG051368
InParanoid Q9YGI5
KO K11994
BRENDA 3.1.21.1
NextBio 20815794
PRO PR:Q9YGI5
Proteomes UP000000539
GO GO:0005576
GO:0005635
GO:0004530
GO:0006915
GO:0006308
Gene3D 3.60.10.10
InterPro IPR018057
IPR016202
IPR005135
PANTHER PTHR11371
Pfam PF03372
PIRSF PIRSF000988
PRINTS PR00130
SMART SM00476
SUPFAM SSF56219
PROSITE PS00919
PS00918

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0070948

regulation of neutrophil mediated cytotoxicity

PMID:29191910[1]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P49183

P

Seeded From UniProt

complete

involved_in

GO:0002673

regulation of acute inflammatory response

PMID:29191910[1]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P49183

P

Seeded From UniProt

complete

involved_in

GO:0002283

neutrophil activation involved in immune response

PMID:29191910[1]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P49183

P

Seeded From UniProt

complete

involved_in

GO:0000737

DNA catabolic process, endonucleolytic

PMID:29191910[1]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P49183

P

Seeded From UniProt

complete

involved_in

GO:0006308

DNA catabolic process

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1913955
PANTHER:PTN002260967
UniProtKB:Q9HXA4

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1314633
PANTHER:PTN000889801
RGD:620669
UniProtKB:Q13609

C

Seeded From UniProt

complete

enables

GO:0004536

deoxyribonuclease activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002260967
RGD:2510
UniProtKB:Q9HXA4

F

Seeded From UniProt

complete

enables

GO:0004530

deoxyribonuclease I activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103157
PANTHER:PTN002260967
RGD:2510

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002260967
RGD:620669

F

Seeded From UniProt

complete

involved_in

GO:0000737

DNA catabolic process, endonucleolytic

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103157
MGI:MGI:1314633
PANTHER:PTN000889801

P

Seeded From UniProt

complete

enables

GO:0004536

deoxyribonuclease activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016202

F

Seeded From UniProt

complete

involved_in

GO:0006308

DNA catabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016202

P

Seeded From UniProt

complete

enables

GO:0004530

deoxyribonuclease I activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.1.21.1

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

enables

GO:0003779

actin binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0009

F

Seeded From UniProt

complete

enables

GO:0004518

nuclease activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0540

F

Seeded From UniProt

complete

enables

GO:0004519

endonuclease activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0255

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

part_of

GO:0005635

nuclear envelope

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0178

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Jiménez-Alcázar, M et al. (2017) Host DNases prevent vascular occlusion by neutrophil extracellular traps. Science 358 1202-1206 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page