CHICK:CTHL1

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	CATHL1 (synonyms: CATH)
Protein Name(s)	Cathelicidin-1 CATH-1 Fowlicidin-1
External Links
UniProt	Q6QLQ5
EMBL	AY534900 DQ092351 DQ092350 AB308318
RefSeq	NP_001001605.1
UniGene	Gga.51464
PDB	2AMN
PDBsum	2AMN
ProteinModelPortal	Q6QLQ5
SMR	Q6QLQ5
PRIDE	Q6QLQ5
Ensembl	ENSGALT00000045759
GeneID	414337
KEGG	gga:414337
CTD	414337
GeneTree	ENSGT00770000120928
HOVERGEN	HBG099601
InParanoid	Q6QLQ5
OMA	GRKLENI
PhylomeDB	Q6QLQ5
EvolutionaryTrace	Q6QLQ5
NextBio	20818692
PRO	PR:Q6QLQ5
Proteomes	UP000000539
ExpressionAtlas	Q6QLQ5
GO	GO:0005576 GO:0042742 GO:0045087
InterPro	IPR001894
PANTHER	PTHR10206
Pfam	PF00666
ProDom	PD001838

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0010629	negative regulation of gene expression	PMID:16326712^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0071222)	Seeded From UniProt	complete
involved_in	GO:0008219	cell death	PMID:16326712^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000066)	Seeded From UniProt	complete
involved_in	GO:0050830	defense response to Gram-positive bacterium	PMID:16326712^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	PMID:16326712^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001530	lipopolysaccharide binding	PMID:16326712^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0019835	cytolysis	PMID:16326712^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000232)	Seeded From UniProt	complete
involved_in	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108443 PANTHER:PTN000024620 UniProtKB:P49913	P		Seeded From UniProt	complete
involved_in	GO:0050830	defense response to Gram-positive bacterium	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108443 PANTHER:PTN000024620 RGD:1559878 UniProtKB:P22226 UniProtKB:P49913 UniProtKB:Q2IAL6 UniProtKB:Q2IAL7 UniProtKB:Q6QLQ5 UniProtKB:R4GJF1	P		Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108443 PANTHER:PTN000024620 RGD:1559878 UniProtKB:P22226 UniProtKB:Q2IAL6 UniProtKB:Q2IAL7 UniProtKB:Q6QLQ5 UniProtKB:R4GJF1	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108443 PANTHER:PTN000024620	P		Seeded From UniProt	complete
part_of	GO:0042581	specific granule	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108443 PANTHER:PTN000024620 UniProtKB:P49913	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:105983 PANTHER:PTN000024620 RGD:1559878 UniProtKB:P49913	C		Seeded From UniProt	complete
enables	GO:0001530	lipopolysaccharide binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000024620 UniProtKB:Q2IAL7 UniProtKB:Q6QLQ5	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001894	C		Seeded From UniProt	complete
involved_in	GO:0006952	defense response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001894	P		Seeded From UniProt	complete
involved_in	GO:0030593	neutrophil chemotaxis	PMID:24491488^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:24491488^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042116	macrophage activation	PMID:24491488^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050830	defense response to Gram-positive bacterium	PMID:24491488^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002381	immunoglobulin production involved in immunoglobulin mediated immune response	PMID:24491488^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001530	lipopolysaccharide binding	PMID:18844294^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:17229147^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051673	membrane disruption in other organism	PMID:17229147^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	PMID:17229147^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050830	defense response to Gram-positive bacterium	PMID:17229147^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0044	P		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Xiao, Y et al. (2006) Identification and functional characterization of three chicken cathelicidins with potent antimicrobial activity. J. Biol. Chem. 281 2858-67 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Bommineni, YR et al. (2014) Immune regulatory activities of fowlicidin-1, a cathelicidin host defense peptide. Mol. Immunol. 59 55-63 PubMed GONUTS page
↑ Bhunia, A et al. (2009) Lipopolysaccharide bound structures of the active fragments of fowlicidin-1, a cathelicidin family of antimicrobial and antiendotoxic peptide from chicken, determined by transferred nuclear Overhauser effect spectroscopy. Biopolymers 92 9-22 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Bommineni, YR et al. (2007) Fowlicidin-3 is an alpha-helical cationic host defense peptide with potent antibacterial and lipopolysaccharide-neutralizing activities. FEBS J. 274 418-28 PubMed GONUTS page

[PMID:16326712-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Xiao, Y et al. (2006) Identification and functional characterization of three chicken cathelicidins with potent antimicrobial activity. J. Biol. Chem. 281 2858-67 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24491488-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Bommineni, YR et al. (2014) Immune regulatory activities of fowlicidin-1, a cathelicidin host defense peptide. Mol. Immunol. 59 55-63 PubMed GONUTS page

[PMID:18844294-4] Bhunia, A et al. (2009) Lipopolysaccharide bound structures of the active fragments of fowlicidin-1, a cathelicidin family of antimicrobial and antiendotoxic peptide from chicken, determined by transferred nuclear Overhauser effect spectroscopy. Biopolymers 92 9-22 PubMed GONUTS page

[PMID:17229147-5] 5.0 ^5.1 ^5.2 ^5.3 Bommineni, YR et al. (2007) Fowlicidin-3 is an alpha-helical cationic host defense peptide with potent antibacterial and lipopolysaccharide-neutralizing activities. FEBS J. 274 418-28 PubMed GONUTS page

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CHICK:CTHL1

Contents

Annotations

Notes

References

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