CHICK:CHK1

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	CHEK1 (synonyms: CHK1)
Protein Name(s)	Serine/threonine-protein kinase Chk1 CHK1 checkpoint homolog Checkpoint kinase-1
External Links
UniProt	Q8AYC9
EMBL	AF525027
RefSeq	NP_989676.1
UniGene	Gga.4288 Gga.48286
ProteinModelPortal	Q8AYC9
SMR	Q8AYC9
BioGrid	675270
STRING	9031.ENSGALP00000040314
PaxDb	Q8AYC9
PRIDE	Q8AYC9
GeneID	374260
KEGG	gga:374260
CTD	3703
eggNOG	COG0515
HOGENOM	HOG000216658
HOVERGEN	HBG002590
InParanoid	Q8AYC9
KO	K02216
PhylomeDB	Q8AYC9
Reactome	REACT_115585 REACT_115715 REACT_115915
NextBio	20813751
PRO	PR:Q8AYC9
Proteomes	UP000000539
GO	GO:0005813 GO:0000785 GO:0000794 GO:0005737 GO:0005654 GO:0005634 GO:0005524 GO:0035402 GO:0004674 GO:0006974 GO:0048096 GO:0000077 GO:0006975 GO:0006281 GO:0006302 GO:0000724 GO:0031572 GO:0035407 GO:0045839 GO:0018107 GO:0010569 GO:2000615 GO:0046602 GO:0010767
InterPro	IPR011009 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:2000615	regulation of histone H3-K9 acetylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35280	P	Seeded From UniProt	complete
involved_in	GO:0048096	chromatin-mediated maintenance of transcription	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35280	P	Seeded From UniProt	complete
involved_in	GO:0046602	regulation of mitotic centrosome separation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14757	P	Seeded From UniProt	complete
involved_in	GO:0045839	negative regulation of mitotic nuclear division	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14757	P	Seeded From UniProt	complete
enables	GO:0035402	histone kinase activity (H3-T11 specific)	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14757	F	Seeded From UniProt	complete
involved_in	GO:0072425	signal transduction involved in G2 DNA damage checkpoint	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14757	P	Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14757	P	Seeded From UniProt	complete
involved_in	GO:0010767	regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35280	P	Seeded From UniProt	complete
involved_in	GO:0010569	regulation of double-strand break repair via homologous recombination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14757	P	Seeded From UniProt	complete
involved_in	GO:0006975	DNA damage induced protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14757	P	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14757	P	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14757	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14757	C	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14757	F	Seeded From UniProt	complete
part_of	GO:0000794	condensed nuclear chromosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14757	C	Seeded From UniProt	complete
part_of	GO:0000785	chromatin	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35280	C	Seeded From UniProt	complete
involved_in	GO:0000077	DNA damage checkpoint	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14757	P	Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104754 MGI:MGI:2445031 PANTHER:PTN000678822 UniProtKB:P57059 UniProtKB:Q9H0K1 UniProtKB:Q9IA88	P	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023169 FB:FBgn0261278 MGI:MGI:104754 MGI:MGI:1202065 MGI:MGI:1336173 MGI:MGI:1347352 MGI:MGI:1351488 MGI:MGI:1923020 MGI:MGI:2445031 MGI:MGI:3037705 PANTHER:PTN000678822 RGD:1359167 RGD:3387 RGD:620545 RGD:620893 RGD:69407 RGD:69653 SGD:S000000931 SGD:S000001531 SGD:S000001584 SGD:S000002529 SGD:S000002885 SGD:S000004086 SGD:S000005127 TAIR:locus:2094672 UniProtKB:O60285 UniProtKB:P57059 UniProtKB:Q13131 UniProtKB:Q6SA08 UniProtKB:Q8IWQ3 UniProtKB:Q8IY84 UniProtKB:Q8TDC3 UniProtKB:Q9BXA6 UniProtKB:Q9BXA7 UniProtKB:Q9H093 UniProtKB:Q9H0K1 UniProtKB:Q9IA88 UniProtKB:Q9NRH2	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104754 MGI:MGI:106924 MGI:MGI:1347559 MGI:MGI:2145955 MGI:MGI:2445031 PANTHER:PTN000678822 PomBase:SPAC23H4.02 PomBase:SPBC32C12.03c PomBase:SPCC297.03 PomBase:SPCC74.03c RGD:3387 RGD:620893 SGD:S000000601 SGD:S000000931 SGD:S000001124 SGD:S000001651 SGD:S000002885 SGD:S000003820 SGD:S000005127 SGD:S000006062 TAIR:locus:2009812 TAIR:locus:2032075 TAIR:locus:2140104 TAIR:locus:2174999 UniProtKB:O14757 UniProtKB:O60285 UniProtKB:P57059 UniProtKB:Q39192 UniProtKB:Q57YE4 UniProtKB:Q7XQP4 UniProtKB:Q8I3C7 UniProtKB:Q8IWQ3 UniProtKB:Q8TDC3 UniProtKB:Q940H6 UniProtKB:Q9IA88 WB:WBGene00002210 WB:WBGene00003919 WB:WBGene00020142 WB:WBGene00021012	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023169 FB:FBgn0261278 MGI:MGI:104754 MGI:MGI:1202065 MGI:MGI:1336173 MGI:MGI:2145955 MGI:MGI:2445031 PANTHER:PTN000678822 PomBase:SPAC23H4.02 PomBase:SPBC19C2.05 PomBase:SPCC74.03c RGD:69407 RGD:69653 SGD:S000001124 SGD:S000002885 SGD:S000003820 SGD:S000005947 TAIR:locus:2009812 TAIR:locus:2032075 TAIR:locus:2140104 TAIR:locus:2159597 TAIR:locus:2160559 TAIR:locus:2174999 UniProtKB:O14757 UniProtKB:O60285 UniProtKB:P43291 UniProtKB:P57059 UniProtKB:Q39192 UniProtKB:Q5N942 UniProtKB:Q7XQP4 UniProtKB:Q8TDC3 UniProtKB:Q940H6 WB:WBGene00002210	C	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0025625 MGI:MGI:104754 MGI:MGI:106924 MGI:MGI:1336173 MGI:MGI:1347559 MGI:MGI:1923020 MGI:MGI:2445031 MGI:MGI:2685946 PANTHER:PTN000678822 PomBase:SPAC57A10.02 PomBase:SPAC644.06c PomBase:SPBC19C2.05 PomBase:SPBC4F6.06 PomBase:SPCC1020.10 PomBase:SPCC297.03 PomBase:SPCC74.03c RGD:1359167 RGD:1563268 RGD:1566256 RGD:3387 RGD:620893 RGD:69407 RGD:69653 SGD:S000000931 SGD:S000001531 SGD:S000001584 SGD:S000002529 SGD:S000002885 SGD:S000004086 SGD:S000005127 SGD:S000005759 TAIR:locus:2009812 TAIR:locus:2094672 TAIR:locus:2102132 UniProtKB:O14757 UniProtKB:O60285 UniProtKB:P57059 UniProtKB:Q14680 UniProtKB:Q6SA08 UniProtKB:Q8IWQ3 UniProtKB:Q8IY84 UniProtKB:Q8TDC3 UniProtKB:Q96PF2 UniProtKB:Q9BXA6 UniProtKB:Q9BXA7 UniProtKB:Q9H093 UniProtKB:Q9H0K1 UniProtKB:Q9IA88 UniProtKB:Q9NRH2 UniProtKB:Q9STV4 WB:WBGene00003919	F	Seeded From UniProt	complete
involved_in	GO:0035407	histone H3-T11 phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0035402	P	Seeded From UniProt	complete
involved_in	GO:0000077	DNA damage checkpoint	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR034670	P	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR034670	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271 InterPro:IPR034670	P	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-GGA-265858 Reactome:R-GGA-217136 Reactome:R-GGA-216941	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0000724	double-strand break repair via homologous recombination	Reactome:R-GGA-351451	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P	Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[1]

CHICK:CHK1

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