CHICK:BRAF

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	BRAF (synonyms: RMIL)
Protein Name(s)	Serine/threonine-protein kinase B-raf Proto-oncogene B-Raf Proto-oncogene c-Rmil Serine/threonine-protein kinase Rmil
External Links
UniProt	Q04982
EMBL	X67052 AF449458
PIR	JN0612
RefSeq	NP_990633.1
UniGene	Gga.719
ProteinModelPortal	Q04982
SMR	Q04982
STRING	9031.ENSGALP00000020950
PaxDb	Q04982
PRIDE	Q04982
GeneID	396239
KEGG	gga:396239
CTD	673
eggNOG	COG0515
HOGENOM	HOG000252972
HOVERGEN	HBG001886
InParanoid	Q04982
KO	K04365
PhylomeDB	Q04982
BRENDA	2.7.11.1
Reactome	REACT_271548 REACT_306420 REACT_330206 REACT_348248
NextBio	20816291
PRO	PR:Q04982
Proteomes	UP000000539
ExpressionAtlas	Q04982
GO	GO:0044297 GO:0005739 GO:0043005 GO:0005634 GO:0005886 GO:0005524 GO:0005509 GO:0004674 GO:0005057 GO:0043367 GO:0071277 GO:0035690 GO:0090150 GO:0015758 GO:0060323 GO:0060291 GO:0002318 GO:2000352 GO:0010764 GO:0043524 GO:2000301 GO:0048680 GO:0050772 GO:0070374 GO:0010628 GO:0033138 GO:0051496 GO:1900026 GO:0043368 GO:0042127 GO:0035019 GO:0008542
InterPro	IPR020454 IPR011009 IPR002219 IPR000719 IPR017441 IPR003116 IPR001245 IPR008271 IPR029071
Pfam	PF00130 PF07714 PF02196
PRINTS	PR00008
SMART	SM00109 SM00455
SUPFAM	SSF54236 SSF56112
PROSITE	PS00107 PS50011 PS00108 PS50898 PS00479 PS50081

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0005886	plasma membrane	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88190 PANTHER:PTN000584635 RGD:619908	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000584576 RGD:2148 UniProtKB:P04049 UniProtKB:P15056	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88065 MGI:MGI:88190 PANTHER:PTN000584576	C	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003079 MGI:MGI:1346881 MGI:MGI:2443258 PANTHER:PTN001908122 RGD:1359261 RGD:619908 RGD:620063 TAIR:locus:2144613 UniProtKB:O43283 UniProtKB:P04049 UniProtKB:P10398 UniProtKB:P15056 UniProtKB:P80192 UniProtKB:Q02779 UniProtKB:Q13418 UniProtKB:Q13546 UniProtKB:Q16584	F	Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001907370 RGD:3531 WB:WBGene00003030	P	Seeded From UniProt	complete
involved_in	GO:0090150	establishment of protein localization to membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15056 ensembl:ENSP00000493543	P	Seeded From UniProt	complete
involved_in	GO:0071277	cellular response to calcium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15056 ensembl:ENSP00000493543	P	Seeded From UniProt	complete
involved_in	GO:0070413	trehalose metabolism in response to stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15056 ensembl:ENSP00000493543	P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15056 ensembl:ENSP00000493543	P	Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15056 ensembl:ENSP00000493543	C	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15056 ensembl:ENSP00000493543	P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15056 ensembl:ENSP00000493543	F	Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15056 ensembl:ENSP00000493543	P	Seeded From UniProt	complete
involved_in	GO:0010828	positive regulation of glucose transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15056 ensembl:ENSP00000493543	P	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15056 ensembl:ENSP00000493543	P	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15056 ensembl:ENSP00000493543	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15056 ensembl:ENSP00000493543	C	Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15056 ensembl:ENSP00000493543	F	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15056 ensembl:ENSP00000493543	F	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15056 ensembl:ENSP00000493543	F	Seeded From UniProt	complete
involved_in	GO:2000352	negative regulation of endothelial cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28028 ensembl:ENSMUSP00000002487	P	Seeded From UniProt	complete
involved_in	GO:2000301	negative regulation of synaptic vesicle exocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28028 ensembl:ENSMUSP00000002487	P	Seeded From UniProt	complete
involved_in	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28028 ensembl:ENSMUSP00000002487	P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28028 ensembl:ENSMUSP00000002487	P	Seeded From UniProt	complete
involved_in	GO:0060324	face development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28028 ensembl:ENSMUSP00000002487	P	Seeded From UniProt	complete
involved_in	GO:0060323	head morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28028 ensembl:ENSMUSP00000002487	P	Seeded From UniProt	complete
involved_in	GO:0060291	long-term synaptic potentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28028 ensembl:ENSMUSP00000002487	P	Seeded From UniProt	complete
involved_in	GO:0051496	positive regulation of stress fiber assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28028 ensembl:ENSMUSP00000002487	P	Seeded From UniProt	complete
involved_in	GO:0050852	T cell receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28028 ensembl:ENSMUSP00000002487	P	Seeded From UniProt	complete
involved_in	GO:0050772	positive regulation of axonogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28028 ensembl:ENSMUSP00000002487	P	Seeded From UniProt	complete
involved_in	GO:0048680	positive regulation of axon regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28028 ensembl:ENSMUSP00000002487	P	Seeded From UniProt	complete
involved_in	GO:0048679	regulation of axon regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28028 ensembl:ENSMUSP00000002487	P	Seeded From UniProt	complete
involved_in	GO:0048538	thymus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28028 ensembl:ENSMUSP00000002487	P	Seeded From UniProt	complete
involved_in	GO:0046632	alpha-beta T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28028 ensembl:ENSMUSP00000002487	P	Seeded From UniProt	complete
involved_in	GO:0045580	regulation of T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28028 ensembl:ENSMUSP00000002487	P	Seeded From UniProt	complete
part_of	GO:0044297	cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28028 ensembl:ENSMUSP00000002487	C	Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28028 ensembl:ENSMUSP00000002487	P	Seeded From UniProt	complete
involved_in	GO:0043369	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28028 ensembl:ENSMUSP00000002487	P	Seeded From UniProt	complete
involved_in	GO:0043368	positive T cell selection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28028 ensembl:ENSMUSP00000002487	P	Seeded From UniProt	complete
involved_in	GO:0043367	CD4-positive, alpha-beta T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28028 ensembl:ENSMUSP00000002487	P	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28028 ensembl:ENSMUSP00000002487	C	Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28028 ensembl:ENSMUSP00000002487	P	Seeded From UniProt	complete
involved_in	GO:0035690	cellular response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28028 ensembl:ENSMUSP00000002487	P	Seeded From UniProt	complete
involved_in	GO:0035019	somatic stem cell population maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28028 ensembl:ENSMUSP00000002487	P	Seeded From UniProt	complete
involved_in	GO:0030878	thyroid gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28028 ensembl:ENSMUSP00000002487	P	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28028 ensembl:ENSMUSP00000002487	P	Seeded From UniProt	complete
involved_in	GO:0010764	negative regulation of fibroblast migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28028 ensembl:ENSMUSP00000002487	P	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28028 ensembl:ENSMUSP00000002487	P	Seeded From UniProt	complete
involved_in	GO:0008542	visual learning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28028 ensembl:ENSMUSP00000002487	P	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28028 ensembl:ENSMUSP00000002487	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28028 ensembl:ENSMUSP00000002487	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28028 ensembl:ENSMUSP00000002487	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28028 ensembl:ENSMUSP00000002487	C	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28028 ensembl:ENSMUSP00000002487	F	Seeded From UniProt	complete
involved_in	GO:0002318	myeloid progenitor cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28028 ensembl:ENSMUSP00000002487	P	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008271	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008271	P	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003116	P	Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002219	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[1]

CHICK:BRAF

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