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CHICK:AFAP1
Contents
| Species (Taxon ID) | Gallus gallus (Chicken). (9031) | |
| Gene Name(s) | AFAP1 | |
| Protein Name(s) | Actin filament-associated protein 1
110 kDa actin filament-associated protein AFAP-110 Neural actin filament protein pp110 | |
| External Links | ||
| UniProt | Q90738 | |
| EMBL | L20303 L20302 | |
| PIR | A54592 A55883 | |
| RefSeq | NP_001128120.1 NP_989536.1 | |
| UniGene | Gga.185 | |
| ProteinModelPortal | Q90738 | |
| IntAct | Q90738 | |
| MINT | MINT-8013618 | |
| STRING | 9031.ENSGALP00000025034 | |
| PaxDb | Q90738 | |
| GeneID | 374034 | |
| KEGG | gga:374034 | |
| CTD | 60312 | |
| eggNOG | NOG48103 | |
| HOGENOM | HOG000033832 | |
| HOVERGEN | HBG106875 | |
| InParanoid | Q90738 | |
| KO | K18616 | |
| PhylomeDB | Q90738 | |
| NextBio | 20813560 | |
| PRO | PR:Q90738 | |
| Proteomes | UP000000539 | |
| GO | GO:0005737 GO:0005856 GO:0051493 GO:0009966 | |
| Gene3D | 2.30.29.30 | |
| InterPro | IPR030113 IPR029907 IPR011993 IPR001849 | |
| PANTHER | PTHR14338 PTHR14338:SF8 | |
| Pfam | PF00169 | |
| SMART | SM00233 | |
| PROSITE | PS50003 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0003779 |
actin binding |
ECO:0000314 |
F |
Figure 1 shows that rAFAP-110 bind to actin filaments directly by using gel electrophoresis, EM negative staining, and centrifugation. |
complete | |||||
| GO:0003779 |
actin binding |
ECO:0000314 |
F |
Figure 2 shows that rAFAP-110 cross links actin through carboxyl terminal region by using a low-speed cosedimentation assay (A), and centrifugation of cross linked actin filaments versus free rAFAP-110 (B). |
complete | |||||
| GO:0003779 |
actin binding |
ECO:0000314 |
F |
Figure 3 shows rAFAP cross links actin filaments by incubating them with rhodamine-phalloidin-labeled actin filaments. |
complete | |||||
| GO:0003779 |
actin binding |
ECO:0000314 |
F |
Figure 7 shows that PKC phosphorylation or leucine zipper deletion increases AFAp-110 ability to cross link actin filaments by incubating them with actin filaments (A) and incubating them with rhodamine-phalloidin-labeled actin filaments. |
complete | |||||
|
involved_in |
GO:0018109 |
peptidyl-arginine phosphorylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0018108 |
peptidyl-tyrosine phosphorylation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042169 |
SH2 domain binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0017124 |
SH3 domain binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009966 |
regulation of signal transduction |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051493 |
regulation of cytoskeleton organization |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0017124 |
SH3 domain binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003779 |
actin binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Qian, Y et al. (2002) PC phosphorylation increases the ability of AFAP-110 to cross-link actin filaments. Mol. Biol. Cell 13 2311-22 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Han, B et al. (2004) Conversion of mechanical force into biochemical signaling. J. Biol. Chem. 279 54793-801 PubMed GONUTS page
- ↑ Lee, A et al. (2000) Stabilization and remodeling of the membrane skeleton during lens fiber cell differentiation and maturation. Dev. Dyn. 217 257-70 PubMed GONUTS page
