CHICK:ACVR1

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	ACVR1
Protein Name(s)	Activin receptor type-1 Activin receptor type I Type I TGF B receptor
External Links
UniProt	Q90ZK6
EMBL	U38622 AJ318064
RefSeq	NP_989891.1
UniGene	Gga.2875
ProteinModelPortal	Q90ZK6
SMR	Q90ZK6
STRING	9031.ENSGALP00000020469
PaxDb	Q90ZK6
Ensembl	ENSGALT00000020497
GeneID	395246
KEGG	gga:395246
CTD	90
eggNOG	COG0515
GeneTree	ENSGT00760000118876
HOGENOM	HOG000230587
HOVERGEN	HBG054502
InParanoid	Q90ZK6
KO	K04675
OMA	GHLCNMN
PhylomeDB	Q90ZK6
NextBio	20815335
PRO	PR:Q90ZK6
Proteomes	UP000000539
GO	GO:0048179 GO:0045177 GO:0005622 GO:0016020 GO:0048185 GO:0016361 GO:0005524 GO:0046872 GO:0005057 GO:0004702 GO:0050431 GO:0005025 GO:0032924 GO:0002526 GO:0003289 GO:0030509 GO:0060317 GO:0060923 GO:0016477 GO:0007368 GO:0003143 GO:0061445 GO:0042118 GO:0000082 GO:0001702 GO:0007281 GO:0007507 GO:0035556 GO:0048762 GO:0001707 GO:0003183 GO:0032926 GO:2001237 GO:0001755 GO:0060389 GO:0001569 GO:0018107 GO:0060037 GO:0010694 GO:0030513 GO:0030501 GO:2000017 GO:0010718 GO:0045669 GO:0010862 GO:0045944 GO:0045893 GO:0051145 GO:0007179
InterPro	IPR011009 IPR000719 IPR017441 IPR008271 IPR000472 IPR003605 IPR000333
PANTHER	PTHR23255
Pfam	PF01064 PF00069 PF08515
PRINTS	PR00653
SMART	SM00467
SUPFAM	SSF56112
PROSITE	PS51256 PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0003289	atrial septum primum morphogenesis	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
involved_in	GO:0003183	mitral valve morphogenesis	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P37172	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q04771	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q04771	F		Seeded From UniProt	complete
enables	GO:0005025	transforming growth factor beta receptor activity, type I	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P37172	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q04771	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q04771	F		Seeded From UniProt	complete
involved_in	GO:0003143	embryonic heart tube morphogenesis	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
involved_in	GO:0002526	acute inflammatory response	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P37172	P		Seeded From UniProt	complete
involved_in	GO:0001755	neural crest cell migration	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P37172	P		Seeded From UniProt	complete
involved_in	GO:0001707	mesoderm formation	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P37172	P		Seeded From UniProt	complete
involved_in	GO:0001702	gastrulation with mouth forming second	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P37172	P		Seeded From UniProt	complete
involved_in	GO:0001569	branching involved in blood vessel morphogenesis	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P37172	P		Seeded From UniProt	complete
involved_in	GO:0000082	G1/S transition of mitotic cell cycle	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
involved_in	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
NOT\|enables	GO:0050431	transforming growth factor beta binding	PMID:10885742^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
NOT\|involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:10885742^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060037	pharyngeal system development	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P37172	P		Seeded From UniProt	complete
involved_in	GO:0051145	smooth muscle cell differentiation	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P37172	P		Seeded From UniProt	complete
involved_in	GO:2000017	positive regulation of determination of dorsal identity	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
involved_in	GO:0071773	cellular response to BMP stimulus	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
involved_in	GO:0061445	endocardial cushion cell fate commitment	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
involved_in	GO:0060923	cardiac muscle cell fate commitment	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
involved_in	GO:0060389	pathway-restricted SMAD protein phosphorylation	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
enables	GO:0050431	transforming growth factor beta binding	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P37172	F		Seeded From UniProt	complete
enables	GO:0050431	transforming growth factor beta binding	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q04771	F		Seeded From UniProt	complete
enables	GO:0048185	activin binding	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P37172	F		Seeded From UniProt	complete
enables	GO:0048185	activin binding	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q04771	F		Seeded From UniProt	complete
part_of	GO:0048179	activin receptor complex	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q04771	C		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q04771	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
involved_in	GO:0030501	positive regulation of bone mineralization	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
part_of	GO:0045177	apical part of cell	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P37172	C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q04771	F		Seeded From UniProt	complete
involved_in	GO:0032926	negative regulation of activin receptor signaling pathway	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
involved_in	GO:0032924	activin receptor signaling pathway	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
involved_in	GO:0030278	regulation of ossification	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
enables	GO:0019838	growth factor binding	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P37172	F		Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
enables	GO:0016361	activin receptor activity, type I	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P37172	F		Seeded From UniProt	complete
contributes_to	GO:0016361	activin receptor activity, type I	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q04771	F		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
involved_in	GO:0009968	negative regulation of signal transduction	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P37172	P		Seeded From UniProt	complete
involved_in	GO:0007498	mesoderm development	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P37172	P		Seeded From UniProt	complete
involved_in	GO:0007369	gastrulation	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P37172	P		Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P37172	P		Seeded From UniProt	complete
involved_in	GO:0007281	germ cell development	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P37172	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P37172	P		Seeded From UniProt	complete
involved_in	GO:1905007	positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	PMID:10885742^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37172	P		Seeded From UniProt	complete
involved_in	GO:0061312	BMP signaling pathway involved in heart development	PMID:10885742^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37172	P		Seeded From UniProt	complete
involved_in	GO:0060412	ventricular septum morphogenesis	PMID:10885742^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37172	P		Seeded From UniProt	complete
involved_in	GO:0003274	endocardial cushion fusion	PMID:10885742^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37172	P		Seeded From UniProt	complete
involved_in	GO:0003203	endocardial cushion morphogenesis	PMID:10885742^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37172	P		Seeded From UniProt	complete
involved_in	GO:0003181	atrioventricular valve morphogenesis	PMID:10885742^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37172	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:12393881^[2]	ECO:0000305	curator inference used in manual assertion	GO:0005025	C		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:12393881^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002129)	Seeded From UniProt	complete
enables	GO:0005025	transforming growth factor beta receptor activity, type I	PMID:12393881^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0002129)	Seeded From UniProt	complete
involved_in	GO:0032924	activin receptor signaling pathway	PMID:12393881^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002129)	Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:12393881^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002129)	Seeded From UniProt	complete
involved_in	GO:0060317	cardiac epithelial to mesenchymal transition	PMID:15766759^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060317	cardiac epithelial to mesenchymal transition	PMID:10885742^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048762	mesenchymal cell differentiation	PMID:10885742^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:15766759^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042118	endothelial cell activation	PMID:15766759^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030513	positive regulation of BMP signaling pathway	PMID:12968668^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:10885742^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	PMID:15766759^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	PMID:10885742^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010694	positive regulation of alkaline phosphatase activity	PMID:15766759^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	PMID:10885742^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005025	transforming growth factor beta receptor activity, type I	PMID:10885742^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0050431	transforming growth factor beta binding	PMID:10885742^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P01137	F		Seeded From UniProt	complete
enables	GO:0098821	BMP receptor activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002356032 UniProtKB:P37023	F		Seeded From UniProt	complete
enables	GO:0048185	activin binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87911 PANTHER:PTN002356032 UniProtKB:P37023 UniProtKB:Q04771	F		Seeded From UniProt	complete
part_of	GO:0048179	activin receptor complex	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002356032 RGD:620200 UniProtKB:Q04771	C		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98728 MGI:MGI:98729 PANTHER:PTN000583675 RGD:621789 UniProtKB:O00238 UniProtKB:P36894 UniProtKB:P36896 UniProtKB:P36897 UniProtKB:P37023 UniProtKB:P37173 UniProtKB:Q04771	F		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000583675 UniProtKB:P27037 UniProtKB:P36896 UniProtKB:P36897 UniProtKB:P37173 UniProtKB:Q13705	C		Seeded From UniProt	complete
enables	GO:0019838	growth factor binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102806 MGI:MGI:87911 MGI:MGI:87912 PANTHER:PTN000583675 RGD:71082 UniProtKB:P36896 UniProtKB:P36897 UniProtKB:Q13705 UniProtKB:Q8NER5	F		Seeded From UniProt	complete
contributes_to	GO:0016361	activin receptor activity, type I	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87911 PANTHER:PTN002356032 RGD:620200 UniProtKB:P37023 UniProtKB:Q04771	F		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87911 PANTHER:PTN001907233 UniProtKB:Q90ZK6	P		Seeded From UniProt	complete
involved_in	GO:0007389	pattern specification process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338938 MGI:MGI:87912 PANTHER:PTN000583675	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003716 MGI:MGI:1338946 MGI:MGI:87911 MGI:MGI:98728 MGI:MGI:98729 PANTHER:PTN000583675 RGD:3852 RGD:620200 RGD:69651 RGD:70964 UniProtKB:A0A0B4KG59 UniProtKB:P36897 UniProtKB:P37023 UniProtKB:P37173 UniProtKB:Q04771 UniProtKB:Q06900 UniProtKB:Q90ZK6	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87911 PANTHER:PTN000583675 RGD:69651 RGD:70964 UniProtKB:P36896 UniProtKB:P37023 UniProtKB:Q04771 UniProtKB:Q13873	C		Seeded From UniProt	complete
enables	GO:0005025	transforming growth factor beta receptor activity, type I	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87911 PANTHER:PTN002356032 UniProtKB:A0A0B4K7J3 UniProtKB:P37023 UniProtKB:Q90ZK6	F		Seeded From UniProt	complete
enables	GO:0005024	transforming growth factor beta-activated receptor activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98728 MGI:MGI:98729 PANTHER:PTN000583675 UniProtKB:A0A0B4KG59 UniProtKB:P36897 UniProtKB:P37023 UniProtKB:P37173 ZFIN:ZDB-GENE-070618-1	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR003605	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR000719 InterPro:IPR003605 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR003605 InterPro:IPR008271	P		Seeded From UniProt	complete
involved_in	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR003605	C		Seeded From UniProt	complete
enables	GO:0050431	transforming growth factor beta binding	PMID:12968668^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0048185	activin binding	PMID:12968668^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
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Notes

References

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↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 ^1.17 ^1.18 ^1.19 ^1.20 ^1.21 ^1.22 ^1.23 ^1.24 ^1.25 ^1.26 ^1.27 ^1.28 ^1.29 ^1.30 ^1.31 ^1.32 ^1.33 ^1.34 ^1.35 ^1.36 ^1.37 ^1.38 ^1.39 ^1.40 ^1.41 ^1.42 ^1.43 ^1.44 ^1.45 ^1.46 ^1.47 ^1.48 ^1.49 ^1.50 ^1.51 ^1.52 ^1.53 ^1.54 ^1.55 ^1.56 ^1.57 ^1.58 ^1.59 ^1.60 ^1.61 ^1.62 ^1.63 ^1.64 ^1.65 ^1.66 ^1.67 ^1.68 Lai, YT et al. (2000) Activin receptor-like kinase 2 can mediate atrioventricular cushion transformation. Dev. Biol. 222 1-11 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Ward, SM et al. (2002) Transforming growth factor beta (TGFbeta ) signaling via differential activation of activin receptor-like kinases 2 and 5 during cardiac development. Role in regulating parasympathetic responsiveness. J. Biol. Chem. 277 50183-9 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Desgrosellier, JS et al. (2005) Activin receptor-like kinase 2 and Smad6 regulate epithelial-mesenchymal transformation during cardiac valve formation. Dev. Biol. 280 201-10 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Zhang, D et al. (2003) ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development. J. Bone Miner. Res. 18 1593-604 PubMed GONUTS page
↑ ^5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 ^5.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:10885742-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 ^1.17 ^1.18 ^1.19 ^1.20 ^1.21 ^1.22 ^1.23 ^1.24 ^1.25 ^1.26 ^1.27 ^1.28 ^1.29 ^1.30 ^1.31 ^1.32 ^1.33 ^1.34 ^1.35 ^1.36 ^1.37 ^1.38 ^1.39 ^1.40 ^1.41 ^1.42 ^1.43 ^1.44 ^1.45 ^1.46 ^1.47 ^1.48 ^1.49 ^1.50 ^1.51 ^1.52 ^1.53 ^1.54 ^1.55 ^1.56 ^1.57 ^1.58 ^1.59 ^1.60 ^1.61 ^1.62 ^1.63 ^1.64 ^1.65 ^1.66 ^1.67 ^1.68 Lai, YT et al. (2000) Activin receptor-like kinase 2 can mediate atrioventricular cushion transformation. Dev. Biol. 222 1-11 PubMed GONUTS page

[PMID:12393881-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Ward, SM et al. (2002) Transforming growth factor beta (TGFbeta ) signaling via differential activation of activin receptor-like kinases 2 and 5 during cardiac development. Role in regulating parasympathetic responsiveness. J. Biol. Chem. 277 50183-9 PubMed GONUTS page

[PMID:15766759-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Desgrosellier, JS et al. (2005) Activin receptor-like kinase 2 and Smad6 regulate epithelial-mesenchymal transformation during cardiac valve formation. Dev. Biol. 280 201-10 PubMed GONUTS page

[PMID:12968668-4] 4.0 ^4.1 ^4.2 Zhang, D et al. (2003) ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development. J. Bone Miner. Res. 18 1593-604 PubMed GONUTS page

[PMID:21873635-5] 5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 ^5.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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