CHICK:ACTN1

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	ACTN1
Protein Name(s)	Alpha-actinin-1 Alpha-actinin cytoskeletal isoform F-actin cross-linking protein Non-muscle alpha-actinin-1
External Links
UniProt	P05094
EMBL	M74143 X13875 J02666 J03486
PIR	A42162
RefSeq	NP_989458.1
UniGene	Gga.4993
PDB	1SJJ
PDBsum	1SJJ
ProteinModelPortal	P05094
SMR	P05094
BioGrid	674968
IntAct	P05094
STRING	9031.ENSGALP00000015409
PaxDb	P05094
PRIDE	P05094
GeneID	373918
KEGG	gga:373918
CTD	87
eggNOG	COG5069
HOGENOM	HOG000263418
HOVERGEN	HBG050453
InParanoid	P05094
KO	K05699
OrthoDB	EOG72C4ZJ
PhylomeDB	P05094
TreeFam	TF352676
EvolutionaryTrace	P05094
NextBio	20813450
PRO	PR:P05094
Proteomes	UP000000539
GO	GO:0005923 GO:0005623 GO:0031252 GO:0097433 GO:0005925 GO:0090637 GO:0030027 GO:0016328 GO:0090636 GO:0001726 GO:0042383 GO:0030486 GO:0001725 GO:1990357 GO:0030018 GO:0005915 GO:0051393 GO:0005509 GO:0030274 GO:0051219 GO:0042803 GO:0017166 GO:0051764 GO:0051017 GO:0045214 GO:0048741
Gene3D	1.10.238.10 1.10.418.10
InterPro	IPR001589 IPR026921 IPR001715 IPR011992 IPR014837 IPR018247 IPR002048 IPR018159 IPR002017
PANTHER	PTHR11915:SF241
Pfam	PF00307 PF13405 PF08726 PF00435
SMART	SM00033 SM00054 SM00150
SUPFAM	SSF47576
PROSITE	PS00019 PS00020 PS50021 PS00018 PS50222

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0097433	dense body	PMID:8006065^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0011903)	Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	PMID:10506181^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0001725	stress fiber	PMID:10506181^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	PMID:19166831^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0017166	vinculin binding	PMID:19166831^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0048741	skeletal muscle fiber development	PMID:19166831^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000515)	Seeded From UniProt	complete
involved_in	GO:0045214	sarcomere organization	PMID:19166831^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000515)	Seeded From UniProt	complete
enables	GO:0017166	vinculin binding	PMID:8037676^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0051393	alpha-actinin binding	PMID:8037676^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:8037676^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005623	cell	PMID:8037676^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0005052)	Seeded From UniProt	complete
part_of	GO:0001725	stress fiber	PMID:9314536^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0011903)	Seeded From UniProt	complete
part_of	GO:0031252	cell leading edge	PMID:9314536^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0011903)	Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:9314536^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0011903)	Seeded From UniProt	complete
enables	GO:0030274	LIM domain binding	PMID:9314536^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P67966	F	occurs_in:(UBERON:0011903)	Seeded From UniProt	complete
part_of	GO:0090637	inner dense plaque of desmosome	PMID:6799520^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0011903)	Seeded From UniProt	complete
part_of	GO:0090636	outer dense plaque of desmosome	PMID:6799520^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0011903)	Seeded From UniProt	complete
part_of	GO:0030486	smooth muscle dense body	PMID:6799520^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0011903)	Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	PMID:6799520^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002108)	Seeded From UniProt	complete
part_of	GO:0005915	zonula adherens	PMID:6799520^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002108)	Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	PMID:6799520^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002108)	Seeded From UniProt	complete
part_of	GO:1990357	terminal web	PMID:6799520^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002108)	Seeded From UniProt	complete
part_of	GO:0030486	smooth muscle dense body	PMID:7622615^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0011903)	Seeded From UniProt	complete
part_of	GO:0005623	cell	PMID:8294495^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0011903)	Seeded From UniProt	complete
enables	GO:0051219	phosphoprotein binding	PMID:8294495^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q04584	F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002048	F		Seeded From UniProt	complete
enables	GO:0051015	actin filament binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026921	F		Seeded From UniProt	complete
involved_in	GO:0051017	actin filament bundle assembly	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026921	P		Seeded From UniProt	complete
involved_in	GO:0051764	actin crosslink formation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026921	P		Seeded From UniProt	complete
part_of	GO:0097433	dense body	PMID:8006065^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0011903)	Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	PMID:10506181^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0001725	stress fiber	PMID:10506181^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	PMID:19166831^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0017166	vinculin binding	PMID:19166831^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0048741	skeletal muscle fiber development	PMID:19166831^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000515)	Seeded From UniProt	complete
involved_in	GO:0045214	sarcomere organization	PMID:19166831^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000515)	Seeded From UniProt	complete
enables	GO:0017166	vinculin binding	PMID:8037676^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0051393	alpha-actinin binding	PMID:8037676^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:8037676^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005623	cell	PMID:8037676^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0005052)	Seeded From UniProt	complete
part_of	GO:0001725	stress fiber	PMID:9314536^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0011903)	Seeded From UniProt	complete
part_of	GO:0031252	cell leading edge	PMID:9314536^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0011903)	Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:9314536^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0011903)	Seeded From UniProt	complete
enables	GO:0030274	LIM domain binding	PMID:9314536^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P67966	F	occurs_in:(UBERON:0011903)	Seeded From UniProt	complete
part_of	GO:0090637	inner dense plaque of desmosome	PMID:6799520^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0011903)	Seeded From UniProt	complete
part_of	GO:0090636	outer dense plaque of desmosome	PMID:6799520^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0011903)	Seeded From UniProt	complete
part_of	GO:0030486	smooth muscle dense body	PMID:6799520^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0011903)	Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	PMID:6799520^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002108)	Seeded From UniProt	complete
part_of	GO:0005915	zonula adherens	PMID:6799520^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002108)	Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	PMID:6799520^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002108)	Seeded From UniProt	complete
part_of	GO:1990357	terminal web	PMID:6799520^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002108)	Seeded From UniProt	complete
part_of	GO:0030486	smooth muscle dense body	PMID:7622615^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0011903)	Seeded From UniProt	complete
enables	GO:0051219	phosphoprotein binding	PMID:8294495^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q04584	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0009	F		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965 UniProtKB-SubCell:SL-0038	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0030018	Z disc	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0314	C		Seeded From UniProt	complete
part_of	GO:0001726	ruffle	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0300	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 North, AJ et al. (1994) Actin isoform compartments in chicken gizzard smooth muscle cells. J. Cell. Sci. 107 ( Pt 3) 445-55 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Pomiès, P et al. (1999) Purification and characterization of an alpha-actinin-binding PDZ-LIM protein that is up-regulated during muscle differentiation. J. Biol. Chem. 274 29242-50 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Zhang, ZQ et al. (2009) Sarcomeric-alpha-actinin defective in vinculin-binding causes Z-line expansion and nemaline-like body formation in cultured chick myotubes. Exp. Cell Res. 315 748-59 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 McGregor, A et al. (1994) Identification of the vinculin-binding site in the cytoskeletal protein alpha-actinin. Biochem. J. 301 ( Pt 1) 225-33 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Pomiès, P et al. (1997) CRP1, a LIM domain protein implicated in muscle differentiation, interacts with alpha-actinin. J. Cell Biol. 139 157-68 PubMed GONUTS page
↑ ^6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 ^6.12 ^6.13 Geiger, B et al. (1981) Immunoelectron microscope studies of membrane-microfilament interactions: distributions of alpha-actinin, tropomyosin, and vinculin in intestinal epithelial brush border and chicken gizzard smooth muscle cells. J. Cell Biol. 91 614-28 PubMed GONUTS page
↑ ^7.0 ^7.1 Terasaki, AG et al. (1995) A high molecular mass protein isolated from chicken gizzard: its localization at the dense plaques and dense bodies of smooth muscle and the Z-disks of skeletal muscle. J. Cell. Sci. 108 ( Pt 3) 857-68 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Crawford, AW et al. (1994) Biochemical and molecular characterization of the chicken cysteine-rich protein, a developmentally regulated LIM-domain protein that is associated with the actin cytoskeleton. J. Cell Biol. 124 117-27 PubMed GONUTS page

[PMID:8006065-1] 1.0 ^1.1 North, AJ et al. (1994) Actin isoform compartments in chicken gizzard smooth muscle cells. J. Cell. Sci. 107 ( Pt 3) 445-55 PubMed GONUTS page

[PMID:10506181-2] 2.0 ^2.1 ^2.2 ^2.3 Pomiès, P et al. (1999) Purification and characterization of an alpha-actinin-binding PDZ-LIM protein that is up-regulated during muscle differentiation. J. Biol. Chem. 274 29242-50 PubMed GONUTS page

[PMID:19166831-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Zhang, ZQ et al. (2009) Sarcomeric-alpha-actinin defective in vinculin-binding causes Z-line expansion and nemaline-like body formation in cultured chick myotubes. Exp. Cell Res. 315 748-59 PubMed GONUTS page

[PMID:8037676-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 McGregor, A et al. (1994) Identification of the vinculin-binding site in the cytoskeletal protein alpha-actinin. Biochem. J. 301 ( Pt 1) 225-33 PubMed GONUTS page

[PMID:9314536-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Pomiès, P et al. (1997) CRP1, a LIM domain protein implicated in muscle differentiation, interacts with alpha-actinin. J. Cell Biol. 139 157-68 PubMed GONUTS page

[PMID:6799520-6] 6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 ^6.12 ^6.13 Geiger, B et al. (1981) Immunoelectron microscope studies of membrane-microfilament interactions: distributions of alpha-actinin, tropomyosin, and vinculin in intestinal epithelial brush border and chicken gizzard smooth muscle cells. J. Cell Biol. 91 614-28 PubMed GONUTS page

[PMID:7622615-7] 7.0 ^7.1 Terasaki, AG et al. (1995) A high molecular mass protein isolated from chicken gizzard: its localization at the dense plaques and dense bodies of smooth muscle and the Z-disks of skeletal muscle. J. Cell. Sci. 108 ( Pt 3) 857-68 PubMed GONUTS page

[PMID:8294495-8] 8.0 ^8.1 ^8.2 Crawford, AW et al. (1994) Biochemical and molecular characterization of the chicken cysteine-rich protein, a developmentally regulated LIM-domain protein that is associated with the actin cytoskeleton. J. Cell Biol. 124 117-27 PubMed GONUTS page

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CHICK:ACTN1

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