CAVPO:INS

Species (Taxon ID)	Cavia porcellus (Guinea pig). (10141)
Gene Name(s)	INS
Protein Name(s)	Insulin Insulin B chain Insulin A chain
External Links
UniProt	P01329
EMBL	K02233 M11713
PIR	A25370
RefSeq	NP_001166362.1 XP_013006103.1
ProteinModelPortal	P01329
SMR	P01329
STRING	10141.ENSCPOP00000019016
PRIDE	P01329
Ensembl	ENSCPOT00000044344
GeneID	100379579
CTD	3630
eggNOG	ENOG410J0XC ENOG4111VJB
GeneTree	ENSGT00390000015440
HOGENOM	HOG000261669
HOVERGEN	HBG006137
InParanoid	P01329
OMA	ELEDPQV
OrthoDB	EOG091G0H56
TreeFam	TF332820
Proteomes	UP000005447
Bgee	ENSCPOG00000008198
GO	GO:0005615 GO:0005179 GO:0042802 GO:0005158 GO:0005159 GO:0002020 GO:0032148 GO:0006953 GO:0046631 GO:0055089 GO:0007186 GO:0042593 GO:0006006 GO:0008286 GO:0002674 GO:0045922 GO:2000252 GO:0045818 GO:0050995 GO:0033861 GO:0042177 GO:0032460 GO:0050709 GO:0045861 GO:1903427 GO:0060266 GO:1990535 GO:0008284 GO:0050715 GO:1902952 GO:0010628 GO:0046326 GO:0045725 GO:0045821 GO:0046628 GO:0043410 GO:0045840 GO:0051092 GO:0010750 GO:0014068 GO:0051897 GO:1900182 GO:0060267 GO:0006521 GO:1903076 GO:0022898 GO:0042060
InterPro	IPR004825 IPR016179 IPR036438 IPR022353 IPR022352
Pfam	PF00049
PRINTS	PR00277 PR00276
SMART	SM00078
SUPFAM	SSF56994
PROSITE	PS00262

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:2000252	negative regulation of feeding behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:1990535	neuron projection maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:1903427	negative regulation of reactive oxygen species biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:1903076	regulation of protein localization to plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:1902952	positive regulation of dendritic spine maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:1900182	positive regulation of protein localization to nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0060267	positive regulation of respiratory burst	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0060266	negative regulation of respiratory burst involved in inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0055089	fatty acid homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0050995	negative regulation of lipid catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0050715	positive regulation of cytokine secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0050709	negative regulation of protein secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0050708	regulation of protein secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0046631	alpha-beta T cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0046628	positive regulation of insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0046326	positive regulation of glucose import	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0045922	negative regulation of fatty acid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0045861	negative regulation of proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0045840	positive regulation of mitotic nuclear division	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0045821	positive regulation of glycolytic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0045818	negative regulation of glycogen catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0045725	positive regulation of glycogen biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	F		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0042177	negative regulation of protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0033861	negative regulation of NAD(P)H oxidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0032880	regulation of protein localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0032460	negative regulation of protein oligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0032270	positive regulation of cellular protein metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0032148	activation of protein kinase B activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0022898	regulation of transmembrane transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0010750	positive regulation of nitric oxide mediated signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0006953	acute-phase response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0006521	regulation of cellular amino acid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	C		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	F		Seeded From UniProt	complete
enables	GO:0005159	insulin-like growth factor receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	F		Seeded From UniProt	complete
enables	GO:0005158	insulin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	F		Seeded From UniProt	complete
involved_in	GO:0002674	negative regulation of acute inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
enables	GO:0002020	protease binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	F		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004825 InterPro:IPR016179 InterPro:IPR022352	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004825 InterPro:IPR016179	C		Seeded From UniProt	complete
involved_in	GO:0005975	carbohydrate metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0119	P		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0372	F		Seeded From UniProt	complete
involved_in	GO:0006006	glucose metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0313	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
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References

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