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CANFA:OX2R

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Species (Taxon ID) Canis familiaris (Dog) (Canis lupus familiaris). (9615)
Gene Name(s) HCRTR2
Protein Name(s) Orexin receptor type 2

Ox-2-R Ox2-R Ox2R Hypocretin receptor type 2

External Links
UniProt Q9TUP7
EMBL AF164626
RefSeq NP_001002933.1
UniGene Cfa.3650
ProteinModelPortal Q9TUP7
STRING 9615.ENSCAFP00000003376
Ensembl ENSCAFT00000003647
GeneID 399545
KEGG cfa:399545
CTD 3062
eggNOG NOG253280
GeneTree ENSGT00760000118781
HOGENOM HOG000230498
HOVERGEN HBG101173
InParanoid Q9TUP7
KO K04239
OMA NSIVVIW
OrthoDB EOG7CG72H
TreeFam TF315303
Reactome REACT_235444
REACT_249096
NextBio 20816603
Proteomes UP000002254
GO GO:0016021
GO:0005886
GO:0016499
GO:0022410
GO:0007631
GO:0007200
InterPro IPR000276
IPR017452
IPR000204
IPR004060
Pfam PF00001
PF03827
PRINTS PR00237
PR01522
PR01064
PROSITE PS00237
PS50262

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O43614

C

Seeded From UniProt

complete

enables

GO:0016499

orexin receptor activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O43614

F

Seeded From UniProt

complete

involved_in

GO:0051480

regulation of cytosolic calcium ion concentration

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O43614

P

Seeded From UniProt

complete

involved_in

GO:0007218

neuropeptide signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O43614

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:11282968[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0051480

regulation of cytosolic calcium ion concentration

PMID:11282968[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007218

neuropeptide signaling pathway

PMID:11282968[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0016499

orexin receptor activity

PMID:11282968[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0010840

regulation of circadian sleep/wake cycle, wakefulness

PMID:11282968[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0016499

orexin receptor activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2680765
PANTHER:PTN000662462
RGD:2788
UniProtKB:O43614

F

Seeded From UniProt

complete

involved_in

GO:0007631

feeding behavior

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000662462
RGD:2788

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0085410
MGI:MGI:2147577
PANTHER:PTN002384851
RGD:1308252
RGD:2787
RGD:2788

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0085410
PANTHER:PTN002384851
UniProtKB:O43613
UniProtKB:O43614
UniProtKB:Q9TUP7

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2147577
PANTHER:PTN002384851
RGD:2788
RGD:708443
RGD:708445

F

Seeded From UniProt

complete

involved_in

GO:0051480

regulation of cytosolic calcium ion concentration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O43614
ensembl:ENSP00000477548

P

Seeded From UniProt

complete

enables

GO:0016499

orexin receptor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O43614
ensembl:ENSP00000477548

F

Seeded From UniProt

complete

involved_in

GO:0007218

neuropeptide signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O43614
ensembl:ENSP00000477548

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O43614
ensembl:ENSP00000477548

C

Seeded From UniProt

complete

enables

GO:0016499

orexin receptor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P58308
ensembl:ENSMUSP00000058230

F

Seeded From UniProt

complete

involved_in

GO:0007200

phospholipase C-activating G protein-coupled receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P58308
ensembl:ENSMUSP00000058230

P

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276

F

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000204
InterPro:IPR000276
InterPro:IPR004060

P

Seeded From UniProt

complete

involved_in

GO:0007631

feeding behavior

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000204
InterPro:IPR004060

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000204
InterPro:IPR000276
InterPro:IPR004060
InterPro:IPR017452

C

Seeded From UniProt

complete

enables

GO:0016499

orexin receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000204
InterPro:IPR004060

F

Seeded From UniProt

complete

involved_in

GO:0022410

circadian sleep/wake cycle process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004060

P

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

F

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0807

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Hungs, M et al. (2001) Identification and functional analysis of mutations in the hypocretin (orexin) genes of narcoleptic canines. Genome Res. 11 531-9 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page