CANAX:RSR1

Species (Taxon ID)	Candida albicans (Yeast). (5476)
Gene Name(s)	RSR1
Protein Name(s)	Ras-related protein RSR1
External Links
UniProt	P52498
EMBL	U46158
ProteinModelPortal	P52498
SMR	P52498
eggNOG	COG1100
GO	GO:0005886 GO:0005525 GO:0006184 GO:0007264
Gene3D	3.40.50.300
InterPro	IPR027417 IPR005225 IPR001806 IPR020849
PANTHER	PTHR24070
Pfam	PF00071
PRINTS	PR00449
SMART	SM00173
SUPFAM	SSF52540
TIGRFAMs	TIGR00231
PROSITE	PS51421

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:2000114	regulation of establishment of cell polarity	PMID:23223038	ECO:0000315			P		Figure 2 shows that mature hyphae lacking Rsr1 had an Spk intensity index that was much less than the wild type index. Spk is known to be needed for hyphal morphogenesis. Mature hyphae lacking Rsr1 had lower Spk intensity than germ tubes lacking Rsr1, showing that Spk decreases over time without Rsr1. Figure 3 shows strains lacking Rsr1 had decreased localization of Mlc1- YFP in the tips when compared to the wild type. Figure 4A shows the overall defects in morphogenesis of organisms lacking Rsr1 compared to the wild type, including wider cells. Figure 5 shows that Rsr1 focuses Cdc42 activity at the tips of germ tubes and is required to maintain polarized growth needed for development. All of these figures show that Rsr1 interacts and regulates Spk vesicles and its components leading to the establishment of cell polarity.	complete CACAO 7615
involved_in	GO:2000114	regulation of establishment of cell polarity	PMID:23223038	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001806	F		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001806 InterPro:IPR005225 InterPro:IPR020849	F		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020849	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020849	C		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0342	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
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References

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