CANAX:DYR

Species (Taxon ID)	Candida albicans (Yeast). (5476)
Gene Name(s)	DFR1
Protein Name(s)	Dihydrofolate reductase
External Links
UniProt	P22906
EMBL	X78968 U84588
PIR	A32203
PDB	1AI9 1AOE 1IA1 1IA2 1IA3 1IA4 1M78 1M79 1M7A 3QLR 3QLS 3QLW 4H95 4H96 4H97 4HOE 4HOF
PDBsum	1AI9 1AOE 1IA1 1IA2 1IA3 1IA4 1M78 1M79 1M7A 3QLR 3QLS 3QLW 4H95 4H96 4H97 4HOE 4HOF
ProteinModelPortal	P22906
SMR	P22906
BindingDB	P22906
ChEMBL	CHEMBL2329
DrugBank	DB03814
UniPathway	UPA00077
EvolutionaryTrace	P22906
GO	GO:0004146 GO:0050661 GO:0006545 GO:0009165 GO:0006730 GO:0046654
CDD	cd00209
Gene3D	3.40.430.10
InterPro	IPR012259 IPR024072 IPR017925 IPR001796
Pfam	PF00186
PRINTS	PR00070
SUPFAM	SSF53597
PROSITE	PS00075 PS51330

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
Contributes to	GO:0004146	dihydrofolate reductase activity	PMID:9374515	ECO:0000247		PMID:9374515 SGD:DFR1	F		The HHpred predicted E-value for this is 1.2E-32. In the literature Fig. 1 compares Candida albicans' Dihydrofolate Reductase to Pneumocystis carinii and they share a 34% match with each other's amino acid sequence. The activity also matches the yeast gene DFR1.	complete CACAO 12630
enables	GO:0004146	dihydrofolate reductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001796 InterPro:IPR017925	F		Seeded From UniProt	complete
involved_in	GO:0046654	tetrahydrofolate biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001796	P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001796 InterPro:IPR017925	P		Seeded From UniProt	complete
enables	GO:0004146	dihydrofolate reductase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.5.1.3	F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
involved_in	GO:0006730	one-carbon metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0554	P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
involved_in	GO:0046654	tetrahydrofolate biosynthetic process	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00077	P		Seeded From UniProt	complete
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References

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