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CANAL:ALS5
Contents
Species (Taxon ID) | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast). (237561) | |
Gene Name(s) | ALS5 (synonyms: ALA1, ALS99) | |
Protein Name(s) | Agglutinin-like protein 5
Adhesin 5 | |
External Links | ||
UniProt | Q5A8T7 | |
EMBL | AACQ01000046 AACQ01000047 | |
RefSeq | XP_718007.1 XP_718074.1 | |
ProteinModelPortal | Q5A8T7 | |
STRING | 5476.CAL0001426 | |
GeneID | 3640277 3640334 | |
KEGG | cal:CaO19.13158 cal:CaO19.5736 | |
CGD | CAL0001426 | |
InParanoid | Q5A8T7 | |
OrthoDB | EOG70KH1Z | |
Proteomes | UP000000559 | |
GO | GO:0031225 GO:0005576 GO:0009277 GO:0005886 GO:0001968 GO:0042277 GO:0044406 GO:0007155 GO:0043710 GO:0043709 GO:0007160 GO:0030260 GO:0009405 GO:0016337 | |
InterPro | IPR008966 IPR008440 IPR024672 | |
Pfam | PF05792 PF11766 | |
SUPFAM | SSF49401 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
involved_in |
GO:0098609 |
cell-cell adhesion |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
CGD:CAL0000199010 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0050839 |
cell adhesion molecule binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002853466 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043710 |
cell adhesion involved in multi-species biofilm formation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
CGD:CAL0000194750 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043709 |
cell adhesion involved in single-species biofilm formation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
CGD:CAL0000194750 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0009277 |
fungal-type cell wall |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
CGD:CAL0000174423 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005618 |
cell wall |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
CGD:CAL0000174423 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0098609 |
cell-cell adhesion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0098609 |
cell-cell adhesion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0098609 |
cell-cell adhesion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0044406 |
adhesion of symbiont to host |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043710 |
cell adhesion involved in multi-species biofilm formation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043709 |
cell adhesion involved in single-species biofilm formation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0042277 |
peptide binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042277 |
peptide binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030260 |
entry into host cell |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0009277 |
fungal-type cell wall |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007160 |
cell-matrix adhesion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007155 |
cell adhesion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007155 |
cell adhesion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007155 |
cell adhesion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0001968 |
fibronectin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007155 |
cell adhesion |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
GO:0046658 |
anchored component of plasma membrane |
ECO:0000314 |
C |
Figure 5: This picture shows the tendency of the protein Als5 to anchor the cell membranes for the fungus' hyphae to invade outside cells. |
complete | |||||
involved_in |
GO:0007155 |
cell adhesion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005618 |
cell wall |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0031225 |
anchored component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 2.0 2.1 Rauceo, JM et al. (2004) Global cell surface conformational shift mediated by a Candida albicans adhesin. Infect. Immun. 72 4948-55 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Sheppard, DC et al. (2004) Functional and structural diversity in the Als protein family of Candida albicans. J. Biol. Chem. 279 30480-9 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Gaur, NK et al. (1999) Overexpression of the Candida albicans ALA1 gene in Saccharomyces cerevisiae results in aggregation following attachment of yeast cells to extracellular matrix proteins, adherence properties similar to those of Candida albicans. Infect. Immun. 67 6040-7 PubMed GONUTS page
- ↑ 5.0 5.1 Klotz, SA et al. (2007) Candida albicans Als proteins mediate aggregation with bacteria and yeasts. Med. Mycol. 45 363-70 PubMed GONUTS page
- ↑ Klotz, SA et al. (2004) Degenerate peptide recognition by Candida albicans adhesins Als5p and Als1p. Infect. Immun. 72 2029-34 PubMed GONUTS page
- ↑ Gaur, NK & Klotz, SA (2004) Accessibility of the peptide backbone of protein ligands is a key specificity determinant in Candida albicans SRS adherence. Microbiology (Reading, Engl.) 150 277-84 PubMed GONUTS page
- ↑ Alsteens, D et al. (2010) Force-induced formation and propagation of adhesion nanodomains in living fungal cells. Proc. Natl. Acad. Sci. U.S.A. 107 20744-9 PubMed GONUTS page
- ↑ Gaur, NK et al. () Candida albicans and Saccharomyces cerevisiae expressing ALA1/ALS5 adhere to accessible threonine, serine, or alanine patches. Cell Commun. Adhes. 9 45-57 PubMed GONUTS page
- ↑ Rauceo, JM et al. (2006) Threonine-rich repeats increase fibronectin binding in the Candida albicans adhesin Als5p. Eukaryotic Cell 5 1664-73 PubMed GONUTS page
- ↑ Garcia-Sherman, MC et al. (2014) Peptide detection of fungal functional amyloids in infected tissue. PLoS ONE 9 e86067 PubMed GONUTS page
c
- Candida
- Candida/Lodderomyces clade
- Candida albicans
- GO:0098609 ! cell-cell adhesion
- GO:0007160 ! cell-matrix adhesion
- GO:0043709 ! cell adhesion involved in single-species biofilm formation
- GO:0043710 ! cell adhesion involved in multi-species biofilm formation
- GO:0050839 ! cell adhesion molecule binding
- GO:0007155 ! cell adhesion
- GO:0005618 ! cell wall
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