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CANAL:ALS5

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Species (Taxon ID) Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast). (237561)
Gene Name(s) ALS5 (synonyms: ALA1, ALS99)
Protein Name(s) Agglutinin-like protein 5

Adhesin 5

External Links
UniProt Q5A8T7
EMBL AACQ01000046
AACQ01000047
RefSeq XP_718007.1
XP_718074.1
ProteinModelPortal Q5A8T7
STRING 5476.CAL0001426
GeneID 3640277
3640334
KEGG cal:CaO19.13158
cal:CaO19.5736
CGD CAL0001426
InParanoid Q5A8T7
OrthoDB EOG70KH1Z
Proteomes UP000000559
GO GO:0031225
GO:0005576
GO:0009277
GO:0005886
GO:0001968
GO:0042277
GO:0044406
GO:0007155
GO:0043710
GO:0043709
GO:0007160
GO:0030260
GO:0009405
GO:0016337
InterPro IPR008966
IPR008440
IPR024672
Pfam PF05792
PF11766
SUPFAM SSF49401

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0098609

cell-cell adhesion

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000199010
PANTHER:PTN002853466
SGD:S000003764
UniProtKB:Q59L12
UniProtKB:Q5A8T7

P

Seeded From UniProt

complete

enables

GO:0050839

cell adhesion molecule binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002853466
SGD:S000003764
UniProtKB:Q59L12

F

Seeded From UniProt

complete

involved_in

GO:0043710

cell adhesion involved in multi-species biofilm formation

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000194750
CGD:CAL0000199010
PANTHER:PTN002531295
UniProtKB:Q59L12
UniProtKB:Q5A312
UniProtKB:Q5A8T7

P

Seeded From UniProt

complete

involved_in

GO:0043709

cell adhesion involved in single-species biofilm formation

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000194750
CGD:CAL0000199010
PANTHER:PTN002531295
UniProtKB:Q59L12
UniProtKB:Q5A312
UniProtKB:Q5A8T7

P

Seeded From UniProt

complete

part_of

GO:0009277

fungal-type cell wall

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000174423
CGD:CAL0000199010
PANTHER:PTN002138603
SGD:S000003764
UniProtKB:Q59L12
UniProtKB:Q5A8T7

C

Seeded From UniProt

complete

part_of

GO:0005618

cell wall

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000174423
CGD:CAL0000199010
PANTHER:PTN002853466
SGD:S000003764
UniProtKB:Q59L12
UniProtKB:Q5A8T7

C

Seeded From UniProt

complete

involved_in

GO:0098609

cell-cell adhesion

PMID:15321986[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0098609

cell-cell adhesion

PMID:15128742[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0098609

cell-cell adhesion

PMID:10531265[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0044406

adhesion of symbiont to host

PMID:10531265[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043710

cell adhesion involved in multi-species biofilm formation

PMID:17510860[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043709

cell adhesion involved in single-species biofilm formation

PMID:17510860[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042277

peptide binding

PMID:15039323[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0042277

peptide binding

PMID:14766905[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0030260

entry into host cell

PMID:15128742[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0009277

fungal-type cell wall

PMID:21059927[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007160

cell-matrix adhesion

PMID:10531265[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

PMID:15321986[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

PMID:15128742[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

PMID:12200964[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0001968

fibronectin binding

PMID:16936142[10]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008440
InterPro:IPR011252
InterPro:IPR033504

P

Seeded From UniProt

complete

GO:0046658

anchored component of plasma membrane

PMID:24465872[11]

ECO:0000314

C

Figure 5: This picture shows the tendency of the protein Als5 to anchor the cell membranes for the fungus' hyphae to invade outside cells.

complete
CACAO 9420

involved_in

GO:0007155

cell adhesion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0130

P

Seeded From UniProt

complete

part_of

GO:0005618

cell wall

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0134
UniProtKB-SubCell:SL-0041

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0031225

anchored component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0336

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964

C

Seeded From UniProt

complete

involved_in

GO:0009405

pathogenesis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0843

P

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. ↑ 2.0 2.1 Rauceo, JM et al. (2004) Global cell surface conformational shift mediated by a Candida albicans adhesin. Infect. Immun. 72 4948-55 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Sheppard, DC et al. (2004) Functional and structural diversity in the Als protein family of Candida albicans. J. Biol. Chem. 279 30480-9 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Gaur, NK et al. (1999) Overexpression of the Candida albicans ALA1 gene in Saccharomyces cerevisiae results in aggregation following attachment of yeast cells to extracellular matrix proteins, adherence properties similar to those of Candida albicans. Infect. Immun. 67 6040-7 PubMed GONUTS page
  5. ↑ 5.0 5.1 Klotz, SA et al. (2007) Candida albicans Als proteins mediate aggregation with bacteria and yeasts. Med. Mycol. 45 363-70 PubMed GONUTS page
  6. ↑ Klotz, SA et al. (2004) Degenerate peptide recognition by Candida albicans adhesins Als5p and Als1p. Infect. Immun. 72 2029-34 PubMed GONUTS page
  7. ↑ Gaur, NK & Klotz, SA (2004) Accessibility of the peptide backbone of protein ligands is a key specificity determinant in Candida albicans SRS adherence. Microbiology (Reading, Engl.) 150 277-84 PubMed GONUTS page
  8. ↑ Alsteens, D et al. (2010) Force-induced formation and propagation of adhesion nanodomains in living fungal cells. Proc. Natl. Acad. Sci. U.S.A. 107 20744-9 PubMed GONUTS page
  9. ↑ Gaur, NK et al. () Candida albicans and Saccharomyces cerevisiae expressing ALA1/ALS5 adhere to accessible threonine, serine, or alanine patches. Cell Commun. Adhes. 9 45-57 PubMed GONUTS page
  10. ↑ Rauceo, JM et al. (2006) Threonine-rich repeats increase fibronectin binding in the Candida albicans adhesin Als5p. Eukaryotic Cell 5 1664-73 PubMed GONUTS page
  11. ↑ Garcia-Sherman, MC et al. (2014) Peptide detection of fungal functional amyloids in infected tissue. PLoS ONE 9 e86067 PubMed GONUTS page
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