BPT4:TYSY

Species (Taxon ID)	Enterobacteria phage T4 (Bacteriophage T4). (10665)
Gene Name(s)	TD
Protein Name(s)	Thymidylate synthase TS TSase
External Links
UniProt	P00471
EMBL	K02035 K01804 AF158101 M12742 J03968
PIR	A00550
RefSeq	NP_049848.1
PDB	1TIS
PDBsum	1TIS
ProteinModelPortal	P00471
SMR	P00471
GeneID	1258770
SABIO-RK	P00471
UniPathway	UPA00575
EvolutionaryTrace	P00471
Proteomes	UP000009087
GO	GO:0004799 GO:0006231 GO:0006235
Gene3D	3.30.572.10
HAMAP	MF_00008
InterPro	IPR023451 IPR000398 IPR020940
Pfam	PF00303
PRINTS	PR00108
SUPFAM	SSF55831
TIGRFAMs	TIGR03284
PROSITE	PS00091

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0004799	thymidylate synthase activity	PMID:894793	ECO:0000315			F		Experiments were performed on wild type T4 td and T4D td6 (a variant containing a missense mutation in the relevant region). A concentration of ~10^13/ml phage ghost particles was collected and thymidylate synthetase activity measured using a radioactive assay of [3H dUMP] for two hours. Table 1 demonstrates thymidylate synthase activity is significantly lower in the td6 mutant (< 0.01 mol/min) than the wild type (0.16 mol/min), indicating that the td gene in T4 phage is involved with thymidylate synthase activity.	complete CACAO 10862
Contributes to	GO:0004799	thymidylate synthase activity	PMID:6328492	ECO:0000315			F		Figure 1: Various restriction enzymes used to make cuts in the thymidylate synthase gene, and clones were generated and analyzed from the fragments.	complete CACAO 12079
enables	GO:0004799	thymidylate synthase activity	PMID:894793	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004799	thymidylate synthase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000398 InterPro:IPR020940	F		Seeded From UniProt	complete
involved_in	GO:0006231	dTMP biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000398 InterPro:IPR020940	P		Seeded From UniProt	complete
enables	GO:0004799	thymidylate synthase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.1.1.45	F		Seeded From UniProt	complete
involved_in	GO:0009165	nucleotide biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0545	P		Seeded From UniProt	complete
enables	GO:0008168	methyltransferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0489	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0032259	methylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0489	P		Seeded From UniProt	complete
involved_in	GO:0006235	dTTP biosynthetic process	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00575	P		Seeded From UniProt	complete
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References

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