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BPP1:DOC
Contents
| Species (Taxon ID) | Enterobacteria phage P1 (Bacteriophage P1). (10678) | |
| Gene Name(s) | doc | |
| Protein Name(s) | Protein kinase doc
Death on curing protein Toxin doc | |
| External Links | ||
| UniProt | Q06259 | |
| EMBL | M95666 AF234172 | |
| PIR | S40016 | |
| RefSeq | YP_006571.1 | |
| PDB | 3DD7 3DD9 3K33 3KH2 | |
| PDBsum | 3DD7 3DD9 3K33 3KH2 | |
| ProteinModelPortal | Q06259 | |
| IntAct | Q06259 | |
| GeneID | 2777474 | |
| EvolutionaryTrace | Q06259 | |
| Proteomes | UP000008091 | |
| GO | GO:0005524 GO:0003677 GO:0016301 GO:0006355 GO:0006417 GO:0006351 | |
| InterPro | IPR006440 IPR003812 | |
| Pfam | PF02661 | |
| PIRSF | PIRSF018297 | |
| TIGRFAMs | TIGR01550 | |
| PROSITE | PS51459 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0039604 |
suppression by virus of host translation |
ECO:0000314 |
P |
Figure 1. Shows total protein levels decreases over time when Doc (from P1 phage) is present. |
complete | |||||
| GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000314 |
F |
Figure 6. shows Doc phosphorylates a threonine residue. |
complete | |||||
| GO:0044696 |
killing by virus of host cell by post-segregational killing |
ECO:0000315 |
P |
Fig (1b) shows that growth the E.coli MC4100 cells is disrupted by introduction of the phd-doc gene into the pGBts plasmid. |
complete | |||||
| GO:0044074 |
negative regulation by symbiont of host translation |
ECO:0000315 |
P |
Fig (3) shows that E.coli cell with the phd-doc plasmid and produced less methionine than cells without the phd-doc system. |
complete | |||||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039604 |
suppression by virus of host translation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004674 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016301 |
kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006417 |
regulation of translation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Liu, M et al. (2008) Bacterial addiction module toxin Doc inhibits translation elongation through its association with the 30S ribosomal subunit. Proc. Natl. Acad. Sci. U.S.A. 105 5885-90 PubMed GONUTS page
- ↑ 2.0 2.1 Cruz, JW et al. (2014) Doc toxin is a kinase that inactivates elongation factor Tu. J. Biol. Chem. 289 7788-98 PubMed GONUTS page
- ↑ 3.0 3.1 Hazan, R et al. (2001) Postsegregational killing mediated by the P1 phage "addiction module" phd-doc requires the Escherichia coli programmed cell death system mazEF. J. Bacteriol. 183 2046-50 PubMed GONUTS page
