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BOVIN:PDIA1

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Species (Taxon ID) Bos taurus (Bovine). (9913)
Gene Name(s) P4HB (synonyms: PDIA1)
Protein Name(s) Protein disulfide-isomerase

PDI Cellular thyroid hormone-binding protein Prolyl 4-hydroxylase subunit beta p55

External Links
UniProt P05307
EMBL M17596
PIR A26829
RefSeq NP_776560.1
UniGene Bt.106831
ProteinModelPortal P05307
SMR P05307
PaxDb P05307
PRIDE P05307
GeneID 281373
KEGG bta:281373
CTD 5034
eggNOG COG0526
HOGENOM HOG000162459
HOVERGEN HBG005920
InParanoid P05307
KO K09580
BioCyc MetaCyc:MONOMER-15199
NextBio 20805377
Proteomes UP000009136
GO GO:0005783
GO:0005788
GO:0042470
GO:0005886
GO:0004656
GO:0003756
GO:0045454
GO:0018401
Gene3D 3.40.30.10
InterPro IPR005788
IPR005792
IPR012336
IPR017937
IPR013766
Pfam PF00085
SUPFAM SSF52833
TIGRFAMs TIGR01130
TIGR01126
PROSITE PS00014
PS00194
PS51352

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0046982

protein heterodimerization activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P07237

F

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P07237

C

Seeded From UniProt

complete

involved_in

GO:0018401

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P07237

P

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P09103

C

Seeded From UniProt

complete

enables

GO:0004656

procollagen-proline 4-dioxygenase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P07237

F

Seeded From UniProt

complete

involved_in

GO:0034976

response to endoplasmic reticulum stress

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000432607
TAIR:locus:2082712
TAIR:locus:2204670
UniProtKB:P07237
UniProtKB:Q9XI01

P

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97464
PANTHER:PTN000432883
UniProtKB:P07237

C

Seeded From UniProt

complete

involved_in

GO:0006457

protein folding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000432607
SGD:S000000548
SGD:S000002926
UniProtKB:C0H4Y6

P

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0014002
MGI:MGI:104864
MGI:MGI:95834
MGI:MGI:97464
PANTHER:PTN000432607
RGD:68430
TAIR:locus:2014681
TAIR:locus:2018134
TAIR:locus:2082712
TAIR:locus:2093447
TAIR:locus:2204670
UniProtKB:P07237
UniProtKB:P30101
UniProtKB:Q9FF55
UniProtKB:Q9XI01
WB:WBGene00003963

C

Seeded From UniProt

complete

enables

GO:0003756

protein disulfide isomerase activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1919080
PANTHER:PTN000432607
RGD:3244
RGD:619835
SGD:S000000548
SGD:S000002926
TAIR:locus:2204670
UniProtKB:C0H4Y6
UniProtKB:O48949
UniProtKB:P07237
UniProtKB:Q4WH99
WB:WBGene00003962
WB:WBGene00003963
WB:WBGene00003964

F

Seeded From UniProt

complete

enables

GO:0003756

protein disulfide isomerase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005792

F

Seeded From UniProt

complete

enables

GO:0016853

isomerase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005788

F

Seeded From UniProt

complete

involved_in

GO:0045454

cell redox homeostasis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013766
InterPro:IPR017937

P

Seeded From UniProt

complete

enables

GO:0003756

protein disulfide isomerase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:5.3.4.1

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

enables

GO:0016853

isomerase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0413

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0256
UniProtKB-SubCell:SL-0095

C

Seeded From UniProt

complete

part_of

GO:0005788

endoplasmic reticulum lumen

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0096

C

Seeded From UniProt

complete

part_of

GO:0042470

melanosome

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0161

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page