BOVIN:CDC42

Species (Taxon ID)	Bos taurus (Bovine). (9913)
Gene Name(s)	CDC42
Protein Name(s)	Cell division control protein 42 homolog
External Links
UniProt	Q2KJ93
EMBL	AAFC03029033 AAFC03029034 AAFC03029036 AAFC03128156 BC105461
RefSeq	NP_001039797.1
UniGene	Bt.56113
ProteinModelPortal	Q2KJ93
SMR	Q2KJ93
BindingDB	Q2KJ93
PRIDE	Q2KJ93
GeneID	532712
KEGG	bta:532712
CTD	998
HOVERGEN	HBG009351
InParanoid	Q2KJ93
KO	K04393
NextBio	20875781
Proteomes	UP000009136
GO	GO:0005737 GO:0016020 GO:0005815 GO:0030496 GO:0072686 GO:0005886 GO:0051233 GO:0005525 GO:0030154 GO:0007399 GO:0032467 GO:1900026 GO:0051988 GO:0051489 GO:0007264
Gene3D	3.40.50.300
InterPro	IPR027417 IPR005225 IPR001806 IPR003578
Pfam	PF00071
SMART	SM00174
SUPFAM	SSF52540
TIGRFAMs	TIGR00231
PROSITE	PS51420

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0007015	actin filament organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60953	P	Seeded From UniProt	complete
involved_in	GO:0006911	phagocytosis, engulfment	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60953	P	Seeded From UniProt	complete
involved_in	GO:0045198	establishment of epithelial cell apical/basal polarity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60953	P	Seeded From UniProt	complete
involved_in	GO:0034329	cell junction assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60953	P	Seeded From UniProt	complete
involved_in	GO:0051491	positive regulation of filopodium assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60766	P	Seeded From UniProt	complete
involved_in	GO:0060997	dendritic spine morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60766	P	Seeded From UniProt	complete
involved_in	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60953	P	Seeded From UniProt	complete
part_of	GO:0072686	mitotic spindle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60953	C	Seeded From UniProt	complete
involved_in	GO:0051988	regulation of attachment of spindle microtubules to kinetochore	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60953	P	Seeded From UniProt	complete
involved_in	GO:0051489	regulation of filopodium assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60953	P	Seeded From UniProt	complete
part_of	GO:0051233	spindle midzone	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60953	C	Seeded From UniProt	complete
involved_in	GO:0032467	positive regulation of cytokinesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60953	P	Seeded From UniProt	complete
part_of	GO:0030496	midbody	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60953	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60953	C	Seeded From UniProt	complete
involved_in	GO:0099563	modification of synaptic structure	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000633069 RGD:71043	P	Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000633069 UniProtKB:P60953	C	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000633069 UniProtKB:P60953	C	Seeded From UniProt	complete
part_of	GO:0042995	cell projection	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106211 PANTHER:PTN001530052	C	Seeded From UniProt	complete
involved_in	GO:0032956	regulation of actin cytoskeleton organization	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001530052 dictyBase:DDB_G0268622 dictyBase:DDB_G0279605	P	Seeded From UniProt	complete
involved_in	GO:0032488	Cdc42 protein signal transduction	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000632904 RGD:71043	P	Seeded From UniProt	complete
involved_in	GO:0030036	actin cytoskeleton organization	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1916831 MGI:MGI:1931551 PANTHER:PTN001530052 UniProtKB:P60953 UniProtKB:P84095 UniProtKB:Q9H4E5	P	Seeded From UniProt	complete
involved_in	GO:0030031	cell projection assembly	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010341 PANTHER:PTN000632904	P	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010341 MGI:MGI:106211 PANTHER:PTN001530052 UniProtKB:P60953 dictyBase:DDB_G0268622 dictyBase:DDB_G0269176 dictyBase:DDB_G0277869 dictyBase:DDB_G0282365	F	Seeded From UniProt	complete
involved_in	GO:0008360	regulation of cell shape	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010341 MGI:MGI:1916831 MGI:MGI:1931551 MGI:MGI:1931553 PANTHER:PTN001530052 UniProtKB:Q7L0Q8 dictyBase:DDB_G0268622	P	Seeded From UniProt	complete
involved_in	GO:0007266	Rho protein signal transduction	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010341 FB:FBgn0014011 MGI:MGI:1931551 PANTHER:PTN000632671 RGD:619921 UniProtKB:I3LVS7 UniProtKB:P61586 UniProtKB:P84095	P	Seeded From UniProt	complete
involved_in	GO:0007163	establishment or maintenance of cell polarity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001530052 UniProtKB:G5EAY4 UniProtKB:Q4WWL5 WB:WBGene00000390 WB:WBGene00009059	P	Seeded From UniProt	complete
involved_in	GO:0007015	actin filament organization	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001530052 RGD:71043 UniProtKB:P60953	P	Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106211 PANTHER:PTN000632904	P	Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010341 PANTHER:PTN001530052 WB:WBGene00000390 dictyBase:DDB_G0277869	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106211 MGI:MGI:1921984 PANTHER:PTN001530052 PomBase:SPAC110.03 RGD:621626 RGD:71043 SGD:S000004219 UniProtKB:P17081 UniProtKB:P60953 WB:WBGene00000390	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010341 MGI:MGI:106211 MGI:MGI:1920546 MGI:MGI:1921984 PANTHER:PTN001530052 UniProtKB:P60953 UniProtKB:Q15669 WB:WBGene00000390 dictyBase:DDB_G0279605	C	Seeded From UniProt	complete
enables	GO:0005525	GTP binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0039140 MGI:MGI:108446 MGI:MGI:97845 PANTHER:PTN000632671 RGD:619755 RGD:619921 RGD:71043 SGD:S000001380 TAIR:locus:2131606 TAIR:locus:2204380 UniProtKB:A0A1D8PDV5 UniProtKB:P15153 UniProtKB:P60953 UniProtKB:P61586 UniProtKB:P63000 UniProtKB:Q15669 UniProtKB:Q9SSX0 WB:WBGene00000390 WB:WBGene00000424 WB:WBGene00004287 WB:WBGene00004357	F	Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010333 FB:FBgn0010341 FB:FBgn0014011 FB:FBgn0014020 MGI:MGI:106211 MGI:MGI:1096342 MGI:MGI:1916831 MGI:MGI:97845 MGI:MGI:97846 PANTHER:PTN000632671 PomBase:SPAC110.03 PomBase:SPAC16.01 PomBase:SPAC16A10.04 PomBase:SPAC1F7.04 PomBase:SPAC23C4.08 RGD:619755 RGD:619921 SGD:S000000046 SGD:S000001380 SGD:S000001763 SGD:S000004219 SGD:S000005034 SGD:S000005124 SGD:S000006369 TAIR:locus:2099232 TAIR:locus:2131606 UniProtKB:A0A1D8PCX9 UniProtKB:A0A1D8PH96 UniProtKB:P17081 UniProtKB:P60763 UniProtKB:P60953 UniProtKB:P61586 UniProtKB:P63000 UniProtKB:P84095 UniProtKB:Q5A904 WB:WBGene00000390 WB:WBGene00000424 WB:WBGene00003239 WB:WBGene00004287 WB:WBGene00004357	F	Seeded From UniProt	complete
part_of	GO:0071944	cell periphery	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60766 ensembl:ENSMUSP00000054634	C	Seeded From UniProt	complete
involved_in	GO:0071346	cellular response to interferon-gamma	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60766 ensembl:ENSMUSP00000054634	P	Seeded From UniProt	complete
involved_in	GO:0060997	dendritic spine morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60766 ensembl:ENSMUSP00000054634	P	Seeded From UniProt	complete
involved_in	GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60766 ensembl:ENSMUSP00000054634	P	Seeded From UniProt	complete
involved_in	GO:0060047	heart contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60766 ensembl:ENSMUSP00000054634	P	Seeded From UniProt	complete
involved_in	GO:0051647	nucleus localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60766 ensembl:ENSMUSP00000054634	P	Seeded From UniProt	complete
involved_in	GO:0051491	positive regulation of filopodium assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60766 ensembl:ENSMUSP00000054634	P	Seeded From UniProt	complete
involved_in	GO:0048664	neuron fate determination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60766 ensembl:ENSMUSP00000054634	P	Seeded From UniProt	complete
involved_in	GO:0046847	filopodium assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60766 ensembl:ENSMUSP00000054634	P	Seeded From UniProt	complete
part_of	GO:0045335	phagocytic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60766 ensembl:ENSMUSP00000054634	C	Seeded From UniProt	complete
part_of	GO:0045177	apical part of cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60766 ensembl:ENSMUSP00000054634	C	Seeded From UniProt	complete
involved_in	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60766 ensembl:ENSMUSP00000054634	P	Seeded From UniProt	complete
involved_in	GO:0043497	regulation of protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60766 ensembl:ENSMUSP00000054634	P	Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60766 ensembl:ENSMUSP00000054634	P	Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60766 ensembl:ENSMUSP00000054634	C	Seeded From UniProt	complete
involved_in	GO:0036336	dendritic cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60766 ensembl:ENSMUSP00000054634	P	Seeded From UniProt	complete
involved_in	GO:0035088	establishment or maintenance of apical/basal cell polarity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60766 ensembl:ENSMUSP00000054634	P	Seeded From UniProt	complete
involved_in	GO:0034613	cellular protein localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60766 ensembl:ENSMUSP00000054634	P	Seeded From UniProt	complete
involved_in	GO:0034332	adherens junction organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60766 ensembl:ENSMUSP00000054634	P	Seeded From UniProt	complete
part_of	GO:0031256	leading edge membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60766 ensembl:ENSMUSP00000054634	C	Seeded From UniProt	complete
enables	GO:0030742	GTP-dependent protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60766 ensembl:ENSMUSP00000054634	F	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60766 ensembl:ENSMUSP00000054634	F	Seeded From UniProt	complete
involved_in	GO:0007097	nuclear migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60766 ensembl:ENSMUSP00000054634	P	Seeded From UniProt	complete
involved_in	GO:0007088	regulation of mitotic nuclear division	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60766 ensembl:ENSMUSP00000054634	P	Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60766 ensembl:ENSMUSP00000054634	P	Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60766 ensembl:ENSMUSP00000054634	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60766 ensembl:ENSMUSP00000054634	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60766 ensembl:ENSMUSP00000054634	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60766 ensembl:ENSMUSP00000054634	C	Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60766 ensembl:ENSMUSP00000054634	F	Seeded From UniProt	complete
involved_in	GO:0003161	cardiac conduction system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60766 ensembl:ENSMUSP00000054634	P	Seeded From UniProt	complete
part_of	GO:0000322	storage vacuole	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60766 ensembl:ENSMUSP00000054634	C	Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001806 InterPro:IPR037874	F	Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001806 InterPro:IPR003578 InterPro:IPR005225	F	Seeded From UniProt	complete
involved_in	GO:0007264	small GTPase mediated signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003578	P	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C	Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P	Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C	Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0342	F	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P	Seeded From UniProt	complete
part_of	GO:0030496	midbody	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0469	C	Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C	Seeded From UniProt	complete
part_of	GO:0005819	spindle	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0251	C	Seeded From UniProt	complete
part_of	GO:0031258	lamellipodium membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0292	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 ^1.17 ^1.18 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21873635-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 ^1.17 ^1.18 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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BOVIN:CDC42

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