BOVIN:BACE1

Species (Taxon ID)	Bos taurus (Bovine). (9913)
Gene Name(s)	BACE1
Protein Name(s)	Beta-secretase 1 Beta-site amyloid precursor protein cleaving enzyme 1 Beta-site APP cleaving enzyme 1 Memapsin-2 Membrane-associated aspartic protease 2
External Links
UniProt	Q2HJ40
EMBL	BC113325
RefSeq	NP_001039996.1
UniGene	Bt.28273
ProteinModelPortal	Q2HJ40
SMR	Q2HJ40
STRING	9913.ENSBTAP00000039837
MEROPS	A01.004
PRIDE	Q2HJ40
Ensembl	ENSBTAT00000040056
GeneID	614333
KEGG	bta:614333
CTD	23621
eggNOG	NOG71700
HOGENOM	HOG000036572
HOVERGEN	HBG059578
InParanoid	Q2HJ40
KO	K04521
OMA	YLMSENH
OrthoDB	EOG7DNNVW
TreeFam	TF329595
NextBio	20899059
Proteomes	UP000009136
ExpressionAtlas	Q2HJ40
GO	GO:0030424 GO:0009986 GO:0030659 GO:0005783 GO:0005768 GO:0005794 GO:0005887 GO:0005771 GO:0005802 GO:0004190 GO:0001540 GO:0050435 GO:0006508
Gene3D	2.40.70.10
InterPro	IPR001461 IPR001969 IPR009119 IPR009120 IPR021109
PANTHER	PTHR13683
Pfam	PF00026
PRINTS	PR01816 PR01815 PR00792
SUPFAM	SSF50630
PROSITE	PS00141

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0009986	cell surface	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56818	C	Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56818	C	Seeded From UniProt	complete
enables	GO:0004190	aspartic-type endopeptidase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56818	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050435	amyloid-beta metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56818	P	Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56817	F	Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56818	C	Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56817	C	Seeded From UniProt	complete
part_of	GO:0005770	late endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56817	C	Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56817	C	Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56817	C	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56817	C	Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56817	C	Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56818	C	Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56818	C	Seeded From UniProt	complete
involved_in	GO:0050435	amyloid-beta metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56817	P	Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56817	P	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56817	C	Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56817	C	Seeded From UniProt	complete
enables	GO:0004190	aspartic-type endopeptidase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56817	F	Seeded From UniProt	complete
involved_in	GO:0050435	amyloid-beta metabolic process	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002299446 RGD:2191 UniProtKB:P56817	P	Seeded From UniProt	complete
involved_in	GO:0030163	protein catabolic process	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000201569 PANTHER:PTN000342793 UniProtKB:P0CY27 UniProtKB:Q5A8N2 UniProtKB:Q5AC08	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346542 MGI:MGI:1860440 PANTHER:PTN002299446 UniProtKB:P56817 UniProtKB:Q9Y5Z0	C	Seeded From UniProt	complete
involved_in	GO:0006509	membrane protein ectodomain proteolysis	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002299446 UniProtKB:P56817 UniProtKB:Q9Y5Z0	P	Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000190503 CGD:CAL0000194661 CGD:CAL0000196689 CGD:CAL0000201140 MGI:MGI:1346542 PANTHER:PTN000342793 RGD:621511 SGD:S000002551 TAIR:locus:2008940 UniProtKB:P00797 UniProtKB:P0CY27 UniProtKB:P41748 UniProtKB:P43094 UniProtKB:P56817 UniProtKB:Q59VH7 UniProtKB:Q5AC08 UniProtKB:Q8I6Z5 WB:WBGene00000217	P	Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346542 PANTHER:PTN002299446 UniProtKB:P56817	C	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346542 PANTHER:PTN002299446 RGD:2191 UniProtKB:P56817 UniProtKB:Q9Y5Z0	C	Seeded From UniProt	complete
part_of	GO:0005768	endosome	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346542 PANTHER:PTN002299446 RGD:2191 UniProtKB:P56817	C	Seeded From UniProt	complete
enables	GO:0004190	aspartic-type endopeptidase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000196689 MGI:MGI:107361 MGI:MGI:1915935 MGI:MGI:88562 PANTHER:PTN000342793 PomBase:SPCC1795.09 RGD:2446 SGD:S000001277 SGD:S000002551 SGD:S000004110 SGD:S000004111 TAIR:locus:2145954 UniProtKB:P00797 UniProtKB:P0CY27 UniProtKB:P14091 UniProtKB:P20142 UniProtKB:P56817 UniProtKB:Q4WNV0 UniProtKB:Q5AC08 UniProtKB:Q8I6Z5 UniProtKB:Q9LTW4 UniProtKB:Q9Y5Z0	F	Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000343246 UniProtKB:P56817	F	Seeded From UniProt	complete
involved_in	GO:2000300	regulation of synaptic vesicle exocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56818 ensembl:ENSMUSP00000034591	P	Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56818 ensembl:ENSMUSP00000034591	C	Seeded From UniProt	complete
part_of	GO:0098686	hippocampal mossy fiber to CA3 synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56818 ensembl:ENSMUSP00000034591	C	Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56818 ensembl:ENSMUSP00000034591	C	Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56818 ensembl:ENSMUSP00000034591	P	Seeded From UniProt	complete
involved_in	GO:0050435	amyloid-beta metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56818 ensembl:ENSMUSP00000034591	P	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56818 ensembl:ENSMUSP00000034591	C	Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56818 ensembl:ENSMUSP00000034591	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56818 ensembl:ENSMUSP00000034591	C	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56818 ensembl:ENSMUSP00000034591	C	Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56818 ensembl:ENSMUSP00000034591	P	Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56818 ensembl:ENSMUSP00000034591	C	Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56818 ensembl:ENSMUSP00000034591	C	Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56818 ensembl:ENSMUSP00000034591	C	Seeded From UniProt	complete
enables	GO:0004190	aspartic-type endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56818 ensembl:ENSMUSP00000034591	F	Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56818 ensembl:ENSMUSP00000034591	F	Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	C	Seeded From UniProt	complete
involved_in	GO:0050435	amyloid-beta metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	P	Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	P	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	F	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	C	Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	F	Seeded From UniProt	complete
involved_in	GO:0006509	membrane protein ectodomain proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	P	Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	C	Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	C	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	C	Seeded From UniProt	complete
part_of	GO:0005771	multivesicular body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	C	Seeded From UniProt	complete
part_of	GO:0005770	late endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	C	Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	C	Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	C	Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	C	Seeded From UniProt	complete
enables	GO:0004190	aspartic-type endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	F	Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	F	Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	F	Seeded From UniProt	complete
enables	GO:0004190	aspartic-type endopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001461 InterPro:IPR001969 InterPro:IPR009119 InterPro:IPR009120	F	Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001461 InterPro:IPR001969 InterPro:IPR009119 InterPro:IPR009120	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009119 InterPro:IPR009120	C	Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0458 UniProtKB-SubCell:SL-0158	C	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256 UniProtKB-SubCell:SL-0095	C	Seeded From UniProt	complete
enables	GO:0004190	aspartic-type endopeptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0064	F	Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P	Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967 UniProtKB-SubCell:SL-0101	C	Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0089	C	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0370	C	Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0094	C	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0310	C	Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0232	C	Seeded From UniProt	complete
part_of	GO:0005770	late endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0152	C	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[1]

BOVIN:BACE1

Contents

Annotations

Notes

References

a

b

c

e

g

h

i

l

m

p

r

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools