GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
ARATH:DRB4
Contents
| Species (Taxon ID) | Arabidopsis thaliana (Mouse-ear cress). (3702) | |
| Gene Name(s) | DBR4 | |
| Protein Name(s) | Double-stranded RNA-binding protein 4
dsRNA-binding protein 4 AtDRB4 | |
| External Links | ||
| UniProt | Q8H1D4 | |
| EMBL | AB455097 AL162651 CP002686 CP002686 CP002686 AY074363 AY150509 | |
| PIR | T48069 | |
| RefSeq | NP_001154686.1 NP_191839.2 NP_974480.1 | |
| UniGene | At.34049 | |
| ProteinModelPortal | Q8H1D4 | |
| SMR | Q8H1D4 | |
| BioGrid | 10769 | |
| IntAct | Q8H1D4 | |
| STRING | 3702.AT3G62800.1-P | |
| PaxDb | Q8H1D4 | |
| PRIDE | Q8H1D4 | |
| EnsemblPlants | AT3G62800.1 AT3G62800.2 | |
| GeneID | 825455 | |
| KEGG | ath:AT3G62800 | |
| TAIR | AT3G62800 | |
| eggNOG | NOG306267 | |
| HOGENOM | HOG000072681 | |
| InParanoid | Q8H1D4 | |
| OMA | YANEREG | |
| PhylomeDB | Q8H1D4 | |
| Proteomes | UP000006548 | |
| Genevestigator | Q8H1D4 | |
| GO | GO:0005634 GO:0003725 GO:0035196 GO:0070919 GO:0010267 GO:0060145 GO:0016032 | |
| Gene3D | 3.30.160.20 | |
| InterPro | IPR014720 | |
| Pfam | PF00035 | |
| SMART | SM00358 | |
| PROSITE | PS50137 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0051607 |
defense response to virus |
ECO:0000315 |
P |
Fig. 1.B. and 1.C. show that drb4 mutants lacking DRB4 have enhanced severity of virus infection symptoms. Viral coat protein levels are higher in drb4 mutants and dcl4 mutants compared to wildtype. However, Fig. 3. shows that viral RNA levels are not elevated (unlike in dcl4 mutants), suggesting that DRB4 does not act in viral gene silencing. |
complete | |||||
|
involved_in |
GO:0051607 |
defense response to virus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060145 |
viral gene silencing in virus induced gene silencing |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070919 |
production of siRNA involved in chromatin silencing by small RNA |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035196 |
production of miRNAs involved in gene silencing by miRNA |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010267 |
production of ta-siRNAs involved in RNA interference |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003725 |
double-stranded RNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006952 |
defense response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031047 |
gene silencing by RNA |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016032 |
viral process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Jakubiec, A et al. (2012) Arabidopsis DRB4 protein in antiviral defense against Turnip yellow mosaic virus infection. Plant J. 69 14-25 PubMed GONUTS page
- ↑ Qu, F et al. (2008) Arabidopsis DRB4, AGO1, AGO7, and RDR6 participate in a DCL4-initiated antiviral RNA silencing pathway negatively regulated by DCL1. Proc. Natl. Acad. Sci. U.S.A. 105 14732-7 PubMed GONUTS page
- ↑ 3.0 3.1 Pélissier, T et al. (2011) Double-stranded RNA binding proteins DRB2 and DRB4 have an antagonistic impact on polymerase IV-dependent siRNA levels in Arabidopsis. RNA 17 1502-10 PubMed GONUTS page
- ↑ Adenot, X et al. (2006) DRB4-dependent TAS3 trans-acting siRNAs control leaf morphology through AGO7. Curr. Biol. 16 927-32 PubMed GONUTS page
- ↑ 5.0 5.1 Hiraguri, A et al. (2005) Specific interactions between Dicer-like proteins and HYL1/DRB-family dsRNA-binding proteins in Arabidopsis thaliana. Plant Mol. Biol. 57 173-88 PubMed GONUTS page
