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HUMAN:TRAF3

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

protected

enables

GO:0019903

protein phosphatase binding

PMID:23871208

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9Y2R2

F

occurs_in:(CL:0000782)

Seeded From UniProt

complete

protected

enables

GO:0005164

tumor necrosis factor receptor binding

PMID:11728344

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9NP84

F

Seeded From UniProt

complete

protected

part_of

GO:0035631

CD40 receptor complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q60803

C

Seeded From UniProt

complete

protected

part_of

GO:0009898

cytoplasmic side of plasma membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q60803

C

Seeded From UniProt

complete

protected

involved_in

GO:0050688

regulation of defense response to virus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q60803

P

Seeded From UniProt

complete

protected

involved_in

GO:0033209

tumor necrosis factor-mediated signaling pathway

PMID:20185819

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0032648

regulation of interferon-beta production

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q60803

P

Seeded From UniProt

complete

protected

involved_in

GO:0032088

negative regulation of NF-kappaB transcription factor activity

PMID:20185819

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0031996

thioesterase binding

PMID:11279055

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q93009

F

Seeded From UniProt

complete

protected

enables

GO:0031625

ubiquitin protein ligase binding

PMID:11279055

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O94972

F

Seeded From UniProt

complete

protected

involved_in

GO:0030162

regulation of proteolysis

PMID:20185819

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0002224

toll-like receptor signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q60803

P

Seeded From UniProt

complete

protected

involved_in

GO:0001817

regulation of cytokine production

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q60803

P

Seeded From UniProt

complete

protected

part_of

GO:0035631

CD40 receptor complex

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107548
MGI:MGI:108041
PANTHER:PTN000805720

C

Seeded From UniProt

complete

protected

involved_in

GO:0033209

tumor necrosis factor-mediated signaling pathway

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:108041
PANTHER:PTN002562108
UniProtKB:Q13114

P

Seeded From UniProt

complete

protected

part_of

GO:0032991

protein-containing complex

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101835
MGI:MGI:107548
MGI:MGI:108041
MGI:MGI:108072
PANTHER:PTN000805648
RGD:1306853
RGD:1310457
UniProtKB:Q12933
UniProtKB:Q9Y4K3

C

Seeded From UniProt

complete

protected

involved_in

GO:0032088

negative regulation of NF-kappaB transcription factor activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:108041
PANTHER:PTN002562108
UniProtKB:Q13114

P

Seeded From UniProt

complete

protected

enables

GO:0031625

ubiquitin protein ligase binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000805720
UniProtKB:O00463
UniProtKB:Q13114

F

Seeded From UniProt

complete

protected

involved_in

GO:0030162

regulation of proteolysis

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:108041
PANTHER:PTN002562108
UniProtKB:Q13114

P

Seeded From UniProt

complete

protected

part_of

GO:0009898

cytoplasmic side of plasma membrane

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107548
MGI:MGI:108041
PANTHER:PTN000805720

C

Seeded From UniProt

complete

protected

enables

GO:0005164

tumor necrosis factor receptor binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000805720
UniProtKB:Q13114

F

Seeded From UniProt

complete

protected

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004842

P

Seeded From UniProt

complete

protected

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004842

P

Seeded From UniProt

complete

protected

involved_in

GO:0050688

regulation of defense response to virus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60803
ensembl:ENSMUSP00000021706

P

Seeded From UniProt

complete

protected

part_of

GO:0035631

CD40 receptor complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60803
ensembl:ENSMUSP00000021706

C

Seeded From UniProt

complete

protected

involved_in

GO:0033209

tumor necrosis factor-mediated signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60803
ensembl:ENSMUSP00000021706

P

Seeded From UniProt

complete

protected

involved_in

GO:0032648

regulation of interferon-beta production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60803
ensembl:ENSMUSP00000021706

P

Seeded From UniProt

complete

protected

involved_in

GO:0032088

negative regulation of NF-kappaB transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60803
ensembl:ENSMUSP00000021706

P

Seeded From UniProt

complete

protected

involved_in

GO:0030162

regulation of proteolysis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60803
ensembl:ENSMUSP00000021706

P

Seeded From UniProt

complete

protected

enables

GO:0019901

protein kinase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60803
ensembl:ENSMUSP00000021706

F

Seeded From UniProt

complete

protected

part_of

GO:0009898

cytoplasmic side of plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60803
ensembl:ENSMUSP00000021706

C

Seeded From UniProt

complete

protected

involved_in

GO:0002224

toll-like receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60803
ensembl:ENSMUSP00000021706

P

Seeded From UniProt

complete

protected

involved_in

GO:0001817

regulation of cytokine production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60803
ensembl:ENSMUSP00000021706

P

Seeded From UniProt

complete

protected

involved_in

GO:0001817

regulation of cytokine production

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR027128
InterPro:IPR037304

P

Seeded From UniProt

complete

protected

enables

GO:0005164

tumor necrosis factor receptor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR027128
InterPro:IPR037304

F

Seeded From UniProt

complete

protected

involved_in

GO:0007165

signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012227

P

Seeded From UniProt

complete

protected

involved_in

GO:0008063

Toll signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR027128
InterPro:IPR037304

P

Seeded From UniProt

complete

protected

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001293
InterPro:IPR012227

F

Seeded From UniProt

complete

protected

involved_in

GO:0032088

negative regulation of NF-kappaB transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR027128
InterPro:IPR037304

P

Seeded From UniProt

complete

protected

involved_in

GO:0033209

tumor necrosis factor-mediated signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR027128
InterPro:IPR037304

P

Seeded From UniProt

complete

protected

involved_in

GO:0042981

regulation of apoptotic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012227

P

Seeded From UniProt

complete

protected

involved_in

GO:0045087

innate immune response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR027128
InterPro:IPR037304

P

Seeded From UniProt

complete

protected

involved_in

GO:0050688

regulation of defense response to virus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR027128
InterPro:IPR037304

P

Seeded From UniProt

complete

protected

involved_in

GO:0007165

signal transduction

PMID:7530216

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0006915

apoptotic process

PMID:10799510

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0035666

TRIF-dependent toll-like receptor signaling pathway

Reactome:R-HSA-936964
Reactome:R-HSA-9013973

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

protected

involved_in

GO:0033209

tumor necrosis factor-mediated signaling pathway

Reactome:R-HSA-5676594
Reactome:R-HSA-5668541

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

protected

involved_in

GO:0016579

protein deubiquitination

Reactome:R-HSA-5688426

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

Reactome:R-HSA-936941
Reactome:R-HSA-936475
Reactome:R-HSA-936381
Reactome:R-HSA-918232
Reactome:R-HSA-918229
Reactome:R-HSA-918227
Reactome:R-HSA-918225
Reactome:R-HSA-9013992
Reactome:R-HSA-9013990
Reactome:R-HSA-9013986
Reactome:R-HSA-9013985
Reactome:R-HSA-9013979
Reactome:R-HSA-9013978
Reactome:R-HSA-9013974
Reactome:R-HSA-5690843
Reactome:R-HSA-5676598
Reactome:R-HSA-5676597
Reactome:R-HSA-5676596
Reactome:R-HSA-5676595
Reactome:R-HSA-5676593
Reactome:R-HSA-5668543
Reactome:R-HSA-5668534
Reactome:R-HSA-5668481
Reactome:R-HSA-5668454
Reactome:R-HSA-5668417
Reactome:R-HSA-5668414
Reactome:R-HSA-5602624
Reactome:R-HSA-5362500
Reactome:R-HSA-5362486
Reactome:R-HSA-2213017
Reactome:R-HSA-2201338
Reactome:R-HSA-166271
Reactome:R-HSA-166245

ECO:0000304

author statement supported by traceable reference used in manual assertion

































C

Seeded From UniProt

complete

protected

enables

GO:0004842

ubiquitin-protein transferase activity

Reactome:R-HSA-9013974
Reactome:R-HSA-2213017

ECO:0000304

author statement supported by traceable reference used in manual assertion


F

Seeded From UniProt

complete

protected

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

protected

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

protected

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

protected

part_of

GO:0005739

mitochondrion

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496
UniProtKB-SubCell:SL-0173

C

Seeded From UniProt

complete

protected

part_of

GO:0005768

endosome

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0967
UniProtKB-SubCell:SL-0101

C

Seeded From UniProt

complete

protected

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete




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