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HUMAN:STK3

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

protected

enables

GO:0004672

protein kinase activity

PMID:28087714

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0006468

protein phosphorylation

PMID:19525978

ECO:0000314

direct assay evidence used in manual assertion

P

has_direct_input:(UniProtKB:P50749)

Seeded From UniProt

complete

protected

involved_in

GO:0090090

negative regulation of canonical Wnt signaling pathway

PMID:20412773

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0035329

hippo signaling

PMID:20412773

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0046983

protein dimerization activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q13043

F

Seeded From UniProt

complete

protected

involved_in

GO:0043065

positive regulation of apoptotic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q13043

P

Seeded From UniProt

complete

protected

involved_in

GO:0035556

intracellular signal transduction

PMID:8566796

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0006468

protein phosphorylation

PMID:20231902

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0006468

protein phosphorylation

PMID:20086174

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0006468

protein phosphorylation

PMID:8566796

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:19525978

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0005524

ATP binding

PMID:8566796

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0004674

protein serine/threonine kinase activity

PMID:19525978

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0004674

protein serine/threonine kinase activity

PMID:18362890

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0004674

protein serine/threonine kinase activity

PMID:18328708

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0004674

protein serine/threonine kinase activity

PMID:8566796

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0000287

magnesium ion binding

PMID:8566796

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0035329

hippo signaling

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1928487
MGI:MGI:1929004
PANTHER:PTN001554629
UniProtKB:Q13043
UniProtKB:Q13188

P

Seeded From UniProt

complete

protected

involved_in

GO:0032147

activation of protein kinase activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1919399
PANTHER:PTN000684825
RGD:727905
UniProtKB:Q7RTN6
UniProtKB:Q9C0K7

P

Seeded From UniProt

complete

protected

involved_in

GO:0031098

stress-activated protein kinase signaling cascade

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000684825
UniProtKB:A0A1D8PKE2
UniProtKB:A0A1D8PM87

P

Seeded From UniProt

complete

protected

involved_in

GO:0023014

signal transduction by protein phosphorylation

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000684825
TAIR:locus:2205523
UniProtKB:Q9UEW8

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0023083
FB:FBgn0025743
FB:FBgn0267698
MGI:MGI:1339975
MGI:MGI:1344404
MGI:MGI:1346867
MGI:MGI:1346875
MGI:MGI:1891638
MGI:MGI:1928487
MGI:MGI:1929004
PANTHER:PTN000684825
PomBase:SPAC1F3.02c
PomBase:SPBC17F3.02
PomBase:SPBC1D7.05
PomBase:SPBC409.07c
PomBase:SPBC543.07
RGD:3780
RGD:620966
RGD:621643
SGD:S000000999
SGD:S000002318
SGD:S000002931
SGD:S000003664
SGD:S000004354
SGD:S000005757
SGD:S000006061
TAIR:locus:2017662
TAIR:locus:2074835
TAIR:locus:2087130
TAIR:locus:2170578
UniProtKB:A0A0B4KGS4
UniProtKB:O00506
UniProtKB:O95819
UniProtKB:Q13043
UniProtKB:Q13153
UniProtKB:Q13177
UniProtKB:Q13188
UniProtKB:Q57Y61
UniProtKB:Q7RTN6
UniProtKB:Q8N4C8
UniProtKB:Q96PY6
UniProtKB:Q9C0K7
UniProtKB:Q9H2G2
UniProtKB:Q9P289
UniProtKB:Q9S7U9
UniProtKB:Q9UKE5
UniProtKB:Q9Y4K4
UniProtKB:Q9Y6E0
UniProtKB:Q9Y6R4
WB:WBGene00002177
WB:WBGene00002201
WB:WBGene00003368
WB:WBGene00013355
dictyBase:DDB_G0284181
dictyBase:DDB_G0286359

C

Seeded From UniProt

complete

protected

enables

GO:0004674

protein serine/threonine kinase activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0023083
FB:FBgn0025743
FB:FBgn0031030
FB:FBgn0035001
FB:FBgn0261456
FB:FBgn0267698
MGI:MGI:1344404
MGI:MGI:1346882
MGI:MGI:1349394
MGI:MGI:1355329
MGI:MGI:1858416
MGI:MGI:1917378
MGI:MGI:1920334
PANTHER:PTN000684825
PomBase:SPBC1604.14c
PomBase:SPBC21.06c
RGD:3250
RGD:3251
RGD:621643
RGD:708455
RGD:727905
SGD:S000005242
TAIR:locus:2035989
TAIR:locus:2045658
TAIR:locus:2080394
TAIR:locus:2116417
TAIR:locus:2133559
TAIR:locus:2174969
TAIR:locus:2205523
TAIR:locus:2206885
UniProtKB:A0A0B4KGS4
UniProtKB:C0H4N8
UniProtKB:O75914
UniProtKB:O94804
UniProtKB:O95747
UniProtKB:O95819
UniProtKB:O96013
UniProtKB:Q02750
UniProtKB:Q12851
UniProtKB:Q13043
UniProtKB:Q13153
UniProtKB:Q13177
UniProtKB:Q13188
UniProtKB:Q13233
UniProtKB:Q8IVH8
UniProtKB:Q8N4C8
UniProtKB:Q92918
UniProtKB:Q99558
UniProtKB:Q9H2G2
UniProtKB:Q9H2K8
UniProtKB:Q9UEW8
UniProtKB:Q9UKE5
UniProtKB:Q9UL54
UniProtKB:Q9Y4K4
UniProtKB:Q9Y6E0
WB:WBGene00013355
WB:WBGene00017472
dictyBase:DDB_G0276459
dictyBase:DDB_G0286359

F

Seeded From UniProt

complete

protected

enables

GO:0004674

protein serine/threonine kinase activity

PMID:16930133

ECO:0000269

experimental evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0004674

protein serine/threonine kinase activity

PMID:15688006

ECO:0000269

experimental evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0004674

protein serine/threonine kinase activity

PMID:15109305

ECO:0000269

experimental evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0004674

protein serine/threonine kinase activity

PMID:11278283

ECO:0000269

experimental evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0051091

positive regulation of DNA-binding transcription factor activity

PMID:22292086

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q9H4B6

P

Seeded From UniProt

complete

protected

involved_in

GO:0050821

protein stabilization

PMID:22292086

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0032991

protein-containing complex

PMID:19962960

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0032092

positive regulation of protein binding

PMID:22292086

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0042802

identical protein binding

PMID:23972470

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q13188

F

Seeded From UniProt

complete

protected

enables

GO:0042802

identical protein binding

PMID:20562859

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q13188

F

Seeded From UniProt

complete

protected

involved_in

GO:0071902

positive regulation of protein serine/threonine kinase activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0043539

P

Seeded From UniProt

complete

protected

involved_in

GO:1902043

positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JI10
ensembl:ENSMUSP00000018476

P

Seeded From UniProt

complete

protected

involved_in

GO:0097284

hepatocyte apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JI10
ensembl:ENSMUSP00000018476

P

Seeded From UniProt

complete

protected

involved_in

GO:0090090

negative regulation of canonical Wnt signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JI10
ensembl:ENSMUSP00000018476

P

Seeded From UniProt

complete

protected

involved_in

GO:0060800

regulation of cell differentiation involved in embryonic placenta development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JI10
ensembl:ENSMUSP00000018476

P

Seeded From UniProt

complete

protected

involved_in

GO:0060706

cell differentiation involved in embryonic placenta development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JI10
ensembl:ENSMUSP00000018476

P

Seeded From UniProt

complete

protected

involved_in

GO:0060215

primitive hemopoiesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JI10
ensembl:ENSMUSP00000018476

P

Seeded From UniProt

complete

protected

involved_in

GO:0051897

positive regulation of protein kinase B signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JI10
ensembl:ENSMUSP00000018476

P

Seeded From UniProt

complete

protected

involved_in

GO:0046621

negative regulation of organ growth

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JI10
ensembl:ENSMUSP00000018476

P

Seeded From UniProt

complete

protected

involved_in

GO:0046330

positive regulation of JNK cascade

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JI10
ensembl:ENSMUSP00000018476

P

Seeded From UniProt

complete

protected

involved_in

GO:0045600

positive regulation of fat cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JI10
ensembl:ENSMUSP00000018476

P

Seeded From UniProt

complete

protected

involved_in

GO:0043065

positive regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JI10
ensembl:ENSMUSP00000018476

P

Seeded From UniProt

complete

protected

involved_in

GO:0035329

hippo signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JI10
ensembl:ENSMUSP00000018476

P

Seeded From UniProt

complete

protected

involved_in

GO:0008285

negative regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JI10
ensembl:ENSMUSP00000018476

P

Seeded From UniProt

complete

protected

involved_in

GO:0007417

central nervous system development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JI10
ensembl:ENSMUSP00000018476

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JI10
ensembl:ENSMUSP00000018476

C

Seeded From UniProt

complete

protected

involved_in

GO:0003157

endocardium development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JI10
ensembl:ENSMUSP00000018476

P

Seeded From UniProt

complete

protected

involved_in

GO:0001841

neural tube formation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JI10
ensembl:ENSMUSP00000018476

P

Seeded From UniProt

complete

protected

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719

F

Seeded From UniProt

complete

protected

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024205

F

Seeded From UniProt

complete

protected

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR017441

F

Seeded From UniProt

complete

protected

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719

P

Seeded From UniProt

complete

protected

involved_in

GO:0007165

signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011524

P

Seeded From UniProt

complete

protected

involved_in

GO:0007165

signal transduction

PMID:8816758

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0004672

protein kinase activity

PMID:10840030
PMID:8816758

ECO:0000304

author statement supported by traceable reference used in manual assertion


F

Seeded From UniProt

complete

protected

enables

GO:0043539

protein serine/threonine kinase activator activity

PMID:20412773

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0035329

hippo signaling

PMID:19484742
Reactome:R-HSA-2028269

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

protected

involved_in

GO:0006915

apoptotic process

PMID:11278283

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

Reactome:R-HSA-2028697
Reactome:R-HSA-2028675
Reactome:R-HSA-2028673
Reactome:R-HSA-2028635
Reactome:R-HSA-2028591
Reactome:R-HSA-2028589

ECO:0000304

author statement supported by traceable reference used in manual assertion






C

Seeded From UniProt

complete

protected

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

protected

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

protected

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

protected

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

protected

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

protected

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

protected

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

protected

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete




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