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HUMAN:GDIR2

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0003924

GTPase activity

PMID:24554735

ECO:0000315

F

Knockdown of siRhoGDI2 in HTR-8/SVneo cells induced the activation of RAC1 as detected by G-LISA, suggesting that RhoGDI2 inhibits RAC1. In contrast, RhoGDI2 overexpression inhibited the activation of RAC1, Figure 6.

complete
CACAO 9541

public

GO:1901164

negative regulation of trophoblast cell migration

PMID:24554735

ECO:0000314

P

Over-expression of RhoGDI2 markedly inhibited the migration of HTR-8/SVneo cells. Knockdown of RhoGDI2 increased the migration of HTR-8/SVneo cells, Figure 5.

complete
CACAO 9543

protected

part_of

GO:0005829

cytosol

PMID:10802295

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:2000249

regulation of actin cytoskeleton reorganization

PMID:8262133

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0035023

regulation of Rho protein signal transduction

PMID:8262133

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0048365

Rac GTPase binding

PMID:7512369

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0035023

regulation of Rho protein signal transduction

PMID:7512369

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0005094

Rho GDP-dissociation inhibitor activity

PMID:7512369

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0005094

Rho GDP-dissociation inhibitor activity

PMID:8356058

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:1901164

negative regulation of trophoblast cell migration

PMID:24554735

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0003924

GTPase activity

PMID:24554735

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

protected

part_of

GO:0070062

extracellular exosome

PMID:19056867

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

protected

part_of

GO:0070062

extracellular exosome

PMID:20458337

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0070062

extracellular exosome

PMID:20458337

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000639)

Seeded From UniProt

complete

protected

enables

GO:0048365

Rac GTPase binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000104723
UniProtKB:P52566

F

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:108430
MGI:MGI:2178103
PANTHER:PTN000104723
RGD:1305383
RGD:1359547
WB:WBGene00004356

C

Seeded From UniProt

complete

protected

involved_in

GO:0007266

Rho protein signal transduction

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2178103
PANTHER:PTN000104723

P

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000104723
RGD:1305383
RGD:1359547
SGD:S000002294
UniProtKB:P52566
UniProtKB:Q99819
UniProtKB:Q9TU03
WB:WBGene00004356
dictyBase:DDB_G0280049
dictyBase:DDB_G0291077

C

Seeded From UniProt

complete

protected

enables

GO:0005094

Rho GDP-dissociation inhibitor activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2178103
PANTHER:PTN000104723
SGD:S000002294
UniProtKB:P52566

F

Seeded From UniProt

complete

protected

involved_in

GO:0043547

positive regulation of GTPase activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005096

P

Seeded From UniProt

complete

protected

involved_in

GO:0050790

regulation of catalytic activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005094

P

Seeded From UniProt

complete

protected

involved_in

GO:0050790

regulation of catalytic activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005094

P

Seeded From UniProt

complete

protected

involved_in

GO:0050790

regulation of catalytic activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005094

P

Seeded From UniProt

complete

protected

involved_in

GO:0050790

regulation of catalytic activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005094

P

Seeded From UniProt

complete

protected

involved_in

GO:0050790

regulation of catalytic activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005094

P

Seeded From UniProt

complete

protected

involved_in

GO:0071461

cellular response to redox state

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5M860
ensembl:ENSRNOP00000007779

P

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5M860
ensembl:ENSRNOP00000007779

C

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5M860
ensembl:ENSRNOP00000007779

C

Seeded From UniProt

complete

protected

enables

GO:0005094

Rho GDP-dissociation inhibitor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000406

F

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000406

C

Seeded From UniProt

complete

protected

part_of

GO:0031410

cytoplasmic vesicle

PMID:9113980

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0007275

multicellular organism development

PMID:8434008

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007162

negative regulation of cell adhesion

PMID:9113980

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0005094

Rho GDP-dissociation inhibitor activity

PMID:8262133

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

protected

part_of

GO:0005856

cytoskeleton

PMID:16130169

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:16130169

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0051056

regulation of small GTPase mediated signal transduction

Reactome:R-HSA-194840

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

Reactome:R-HSA-195146
Reactome:R-HSA-194854

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

protected

enables

GO:0005096

GTPase activator activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0343

F

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0091

C

Seeded From UniProt

complete



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