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MOUSE:P85A

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0032762

mast cell cytokine production

PMID:24454942

ECO:0000315

P

Fig. 6D shows PI3K KO mice exhibit lower expression of cytokines in mucosal cells compared to WT mice. Fig. 6C shows similar cytokine expression in KO and WT mice, suggesting that PI3K is involved in gastrointestinal mast cell cytokine production and not systemic mast cell cytokine production.

complete
CACAO 9386

protected

enables

GO:0046982

protein heterodimerization activity

PMID:20348926

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O08908

F

Seeded From UniProt

complete

protected

involved_in

GO:0042307

positive regulation of protein import into nucleus

PMID:20348926

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • has_regulation_target:(UniProtKB:O35426)
  • part_of:(GO:0008286)

Seeded From UniProt

complete

protected

enables

GO:0036312

phosphatidylinositol 3-kinase regulatory subunit binding

PMID:20348926

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O08908

F

Seeded From UniProt

complete

protected

involved_in

GO:1900103

positive regulation of endoplasmic reticulum unfolded protein response

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P27986

P

Seeded From UniProt

complete

protected

involved_in

GO:0050821

protein stabilization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P27986

P

Seeded From UniProt

complete

protected

involved_in

GO:0042307

positive regulation of protein import into nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P27986

P

Seeded From UniProt

complete

protected

involved_in

GO:0033120

positive regulation of RNA splicing

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P27986

P

Seeded From UniProt

complete

protected

involved_in

GO:0001678

cellular glucose homeostasis

PMID:20348926

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:20348926

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:20348926

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0042307

positive regulation of protein import into nucleus

PMID:20348926

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0034976

response to endoplasmic reticulum stress

PMID:20348926

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0032869

cellular response to insulin stimulus

PMID:20348926

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0008134

transcription factor binding

PMID:20348926

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O08908

F

Seeded From UniProt

complete

protected

enables

GO:0008134

transcription factor binding

PMID:20348926

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O35426-2

F

Seeded From UniProt

complete

protected

involved_in

GO:0008286

insulin receptor signaling pathway

PMID:20348926

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0048009

insulin-like growth factor receptor signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P27986

P

Seeded From UniProt

complete

protected

involved_in

GO:0046854

phosphatidylinositol phosphorylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O18683

P

Seeded From UniProt

complete

protected

enables

GO:0043560

insulin receptor substrate binding

PMID:16043515

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P35568

F

Seeded From UniProt

complete

protected

enables

GO:0043125

ErbB-3 class receptor binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P27986

F

Seeded From UniProt

complete

protected

enables

GO:0035014

phosphatidylinositol 3-kinase regulator activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O18683

F

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

PMID:16043515

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0008286

insulin receptor signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P27986

P

Seeded From UniProt

complete

protected

part_of

GO:0005943

phosphatidylinositol 3-kinase complex, class IA

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O18683

C

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

PMID:16043515

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:16043515

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0005159

insulin-like growth factor receptor binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P27986

F

Seeded From UniProt

complete

protected

enables

GO:0005158

insulin receptor binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P27986

F

Seeded From UniProt

complete

protected

enables

GO:0046935

1-phosphatidylinositol-3-kinase regulator activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:109277
PANTHER:PTN000806614
RGD:3329
RGD:621042

F

Seeded From UniProt

complete

protected

involved_in

GO:0046854

phosphatidylinositol phosphorylation

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0020622
PANTHER:PTN000806614
UniProtKB:P23727

P

Seeded From UniProt

complete

protected

involved_in

GO:0043551

regulation of phosphatidylinositol 3-kinase activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000016388
RGD:3329
UniProtKB:P23727

P

Seeded From UniProt

complete

protected

involved_in

GO:0008286

insulin receptor signaling pathway

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:109277
MGI:MGI:1098772
MGI:MGI:97583
PANTHER:PTN000016388
RGD:3329
UniProtKB:P23727
WB:WBGene00000001

P

Seeded From UniProt

complete

protected

part_of

GO:0005942

phosphatidylinositol 3-kinase complex

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:109277
PANTHER:PTN000806614
RGD:3329
UniProtKB:P23727
WB:WBGene00000001

C

Seeded From UniProt

complete

protected

part_of

GO:1990578

perinuclear endoplasmic reticulum membrane

PMID:25217619

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1903076

regulation of protein localization to plasma membrane

PMID:25217619

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1900103

positive regulation of endoplasmic reticulum unfolded protein response

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P27986

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0060396

growth hormone receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P27986

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0051591

response to cAMP

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3329

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0051492

regulation of stress fiber assembly

PMID:25217619

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2149438

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0051384

response to glucocorticoid

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3329

P

Seeded From UniProt

complete

protected

enables

GO:0051219

phosphoprotein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3329

F

Seeded From UniProt

complete

protected

enables

GO:0051117

ATPase binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3329

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0050821

protein stabilization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P27986

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0048662

negative regulation of smooth muscle cell proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3329

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0048009

insulin-like growth factor receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P27986

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0048009

insulin-like growth factor receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3329

P

Seeded From UniProt

complete

protected

enables

GO:0046935

1-phosphatidylinositol-3-kinase regulator activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3329

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0046626

regulation of insulin receptor signaling pathway

PMID:26657864

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88315

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:17242187

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2149414

P

  • regulates_o_occurs_in:(CL:0000057)
  • has_regulation_target:(MGI:MGI:104798)

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P27986

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0045861

negative regulation of proteolysis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3329

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0045776

negative regulation of blood pressure

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3329

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0045671

negative regulation of osteoclast differentiation

PMID:17053831

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97306

P

regulates_o_results_in_acquisition_of_features_of:(CL:0000092)

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0045663

positive regulation of myoblast differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3329

P

Seeded From UniProt

complete

protected

enables

GO:0043560

insulin receptor substrate binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3329

F

Seeded From UniProt

complete

protected

enables

GO:0043559

insulin binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P27986

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0043551

regulation of phosphatidylinositol 3-kinase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3329

P

Seeded From UniProt

complete

protected

enables

GO:0043125

ErbB-3 class receptor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P27986

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:15192701

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P27986

P

Seeded From UniProt

complete

protected

part_of

GO:0043005

neuron projection

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3329

C

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0042307

positive regulation of protein import into nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P27986

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0034976

response to endoplasmic reticulum stress

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P27986

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0034644

cellular response to UV

PMID:17242187

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:103296

P

occurs_in:(CL:0000057)|occurs_in:(CL:0000057)

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0034644

cellular response to UV

PMID:17242187

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2149414

P

occurs_in:(CL:0000057)

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0033120

positive regulation of RNA splicing

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P27986

P

Seeded From UniProt

complete

protected

part_of

GO:0032991

protein-containing complex

PMID:26657864

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0032991

protein-containing complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3329

C

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0032869

cellular response to insulin stimulus

PMID:26657864

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0032868

response to insulin

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3329

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0032760

positive regulation of tumor necrosis factor production

PMID:17242187

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0031625

ubiquitin protein ligase binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3329

F

Seeded From UniProt

complete

protected

enables

GO:0030971

receptor tyrosine kinase binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3329

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0030335

positive regulation of cell migration

PMID:17053831

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97306

P

regulates_o_results_in_movement_of:(CL:0000092)

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0030335

positive regulation of cell migration

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3329

P

Seeded From UniProt

complete

protected

enables

GO:0030331

estrogen receptor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3329

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0030183

B cell differentiation

PMID:9988280

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2149414

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0022408

negative regulation of cell-cell adhesion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3329

P

Seeded From UniProt

complete

protected

enables

GO:0019904

protein domain specific binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3329

F

Seeded From UniProt

complete

protected

enables

GO:0019903

protein phosphatase binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P27986

F

Seeded From UniProt

complete

protected

enables

GO:0019901

protein kinase binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3329

F

Seeded From UniProt

complete

protected

contributes_to

GO:0016303

1-phosphatidylinositol-3-kinase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3329

F

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3329

C

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0014065

phosphatidylinositol 3-kinase signaling

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P27986

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0010656

negative regulation of muscle cell apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3329

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0010628

positive regulation of gene expression

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3329

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0010459

negative regulation of heart rate

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3329

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

PMID:17242187

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:104798

P

occurs_in:(CL:0000057)

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

PMID:17242187

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2149414

P

occurs_in:(CL:0000057)

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0008625

extrinsic apoptotic signaling pathway via death domain receptors

PMID:15039234

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97306

P

  • regulates_o_occurs_in:(EMAPA:32760)
  • regulates_o_occurs_in:(CL:0000097)

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0008625

extrinsic apoptotic signaling pathway via death domain receptors

PMID:15039234

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • regulates_o_occurs_in:(EMAPA:32760)
  • regulates_o_occurs_in:(CL:0000097)

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0008286

insulin receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3329

P

Seeded From UniProt

complete

protected

enables

GO:0008134

transcription factor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P27986

F

Seeded From UniProt

complete

protected

enables

GO:0008022

protein C-terminus binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3329

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0007162

negative regulation of cell adhesion

PMID:25217619

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0006606

protein import into nucleus

PMID:17242187

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2149414

P

  • occurs_in:(CL:0000057)
  • has_direct_input:(MGI:MGI:1920431)

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0006468

protein phosphorylation

PMID:15192701

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0006006

glucose metabolic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3329

P

Seeded From UniProt

complete

protected

part_of

GO:0005942

phosphatidylinositol 3-kinase complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3329

C

Seeded From UniProt

complete

protected

part_of

GO:0005911

cell-cell junction

PMID:23793062

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3329

C

Seeded From UniProt

complete

protected

part_of

GO:0005801

cis-Golgi network

PMID:25217619

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P27986

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3329

C

Seeded From UniProt

complete

protected

enables

GO:0005516

calmodulin binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3329

F

Seeded From UniProt

complete

protected

enables

GO:0005168

neurotrophin TRKA receptor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P27986

F

Seeded From UniProt

complete

protected

enables

GO:0005161

platelet-derived growth factor receptor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3329

F

Seeded From UniProt

complete

protected

enables

GO:0005159

insulin-like growth factor receptor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P27986

F

Seeded From UniProt

complete

protected

enables

GO:0005158

insulin receptor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P27986

F

Seeded From UniProt

complete

protected

enables

GO:0005102

signaling receptor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3329

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0001953

negative regulation of cell-matrix adhesion

PMID:17053831

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97306

P

regulates_o_has_participant:(CL:0000092)

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0001934

positive regulation of protein phosphorylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3329

P

Seeded From UniProt

complete

protected

enables

GO:0001784

phosphotyrosine residue binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P27986

F

Seeded From UniProt

complete

protected

involved_in

GO:0036092

phosphatidylinositol-3-phosphate biosynthetic process

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0016303

P

Seeded From UniProt

complete

protected

involved_in

GO:0036092

phosphatidylinositol-3-phosphate biosynthetic process

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0016303

P

Seeded From UniProt

complete

protected

involved_in

GO:1900103

positive regulation of endoplasmic reticulum unfolded protein response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P27986
ensembl:ENSP00000428056

P

Seeded From UniProt

complete

protected

involved_in

GO:0060396

growth hormone receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P27986
ensembl:ENSP00000428056

P

Seeded From UniProt

complete

protected

involved_in

GO:0050821

protein stabilization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P27986
ensembl:ENSP00000428056

P

Seeded From UniProt

complete

protected

involved_in

GO:0048009

insulin-like growth factor receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P27986
ensembl:ENSP00000428056

P

Seeded From UniProt

complete

protected

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P27986
ensembl:ENSP00000428056

P

Seeded From UniProt

complete

protected

enables

GO:0043559

insulin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P27986
ensembl:ENSP00000428056

F

Seeded From UniProt

complete

protected

enables

GO:0043125

ErbB-3 class receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P27986
ensembl:ENSP00000428056

F

Seeded From UniProt

complete

protected

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P27986
ensembl:ENSP00000428056

P

Seeded From UniProt

complete

protected

involved_in

GO:0042307

positive regulation of protein import into nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P27986
ensembl:ENSP00000428056

P

Seeded From UniProt

complete

protected

involved_in

GO:0034976

response to endoplasmic reticulum stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P27986
ensembl:ENSP00000428056

P

Seeded From UniProt

complete

protected

involved_in

GO:0033120

positive regulation of RNA splicing

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P27986
ensembl:ENSP00000428056

P

Seeded From UniProt

complete

protected

enables

GO:0019903

protein phosphatase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P27986
ensembl:ENSP00000428056

F

Seeded From UniProt

complete

protected

involved_in

GO:0014065

phosphatidylinositol 3-kinase signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P27986
ensembl:ENSP00000428056

P

Seeded From UniProt

complete

protected

enables

GO:0008134

transcription factor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P27986
ensembl:ENSP00000428056

F

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P27986
ensembl:ENSP00000428056

C

Seeded From UniProt

complete

protected

enables

GO:0005168

neurotrophin TRKA receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P27986
ensembl:ENSP00000428056

F

Seeded From UniProt

complete

protected

enables

GO:0005159

insulin-like growth factor receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P27986
ensembl:ENSP00000428056

F

Seeded From UniProt

complete

protected

enables

GO:0005158

insulin receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P27986
ensembl:ENSP00000428056

F

Seeded From UniProt

complete

protected

enables

GO:0001784

phosphotyrosine residue binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P27986
ensembl:ENSP00000428056

F

Seeded From UniProt

complete

protected

part_of

GO:0005942

phosphatidylinositol 3-kinase complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001720

C

Seeded From UniProt

complete

protected

involved_in

GO:0007165

signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000198
InterPro:IPR008936

P

Seeded From UniProt

complete

protected

enables

GO:0035014

phosphatidylinositol 3-kinase regulator activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001720

F

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

Reactome:R-NUL-9616944
Reactome:R-NUL-9603412
Reactome:R-NUL-9031077
Reactome:R-MMU-9031553
Reactome:R-MMU-9027268
Reactome:R-MMU-5218853

ECO:0000304

author statement supported by traceable reference used in manual assertion






C

Seeded From UniProt

complete

protected

enables

GO:0016303

1-phosphatidylinositol-3-kinase activity

PMID:9988280

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

protected

part_of

GO:0005942

phosphatidylinositol 3-kinase complex

PMID:9988280

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0015031

protein transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0653

P

Seeded From UniProt

complete




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