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Dai, X, Jiang, W, Zhang, Q, Xu, L, Geng, P, Zhuang, S, Petrich, BG, Jiang, C, Peng, L, Bhattacharya, S, Evans, SM, Sun, Y, Chen, J and Liang, X (2013) Requirement for Integrin-linked kinase in neural crest migration and differentiation and outflow tract morphogenesis. BMC Biol. 11:107
Neural crest defects lead to congenital heart disease involving outflow tract malformation. Integrin-linked-Kinase (ILK) plays important roles in multiple cellular processes and embryogenesis. ILK is expressed in neural crest, but its role in neural crest and outflow tract morphogenesis remains unknown.