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MOUSE:MK12

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0000165

MAPK cascade

PMID:24090933

ECO:0000314

P

Figure 5D. Shows inhibition of SAPK/JNK decreases levels of HSF1.

complete
CACAO 8843

public

GO:0000165

MAPK cascade

PMID:24090933

ECO:0000314

P

Figure 5E. Shows OCT4 activity increase when SAPK/JNK is inhibited

complete
CACAO 8844

protected

involved_in

GO:0071310

cellular response to organic substance

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001172432
RGD:70500

P

Seeded From UniProt

complete

protected

involved_in

GO:0035556

intracellular signal transduction

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:106908
MGI:MGI:1201387
MGI:MGI:1201408
MGI:MGI:1346865
PANTHER:PTN000622075
RGD:3046
RGD:70500
RGD:71050
UniProtKB:P78362
UniProtKB:Q16539
UniProtKB:Q96SB4
UniProtKB:Q9UPZ9
WB:WBGene00004055
WB:WBGene00004056

P

Seeded From UniProt

complete

protected

involved_in

GO:0010468

regulation of gene expression

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1346861
PANTHER:PTN000622075
UniProtKB:A9T142

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0052703
FB:FBgn0267339
MGI:MGI:1201408
MGI:MGI:1346347
MGI:MGI:1346858
MGI:MGI:1346859
MGI:MGI:1346861
MGI:MGI:1346862
MGI:MGI:1346863
MGI:MGI:1346865
MGI:MGI:1354946
MGI:MGI:2444559
PANTHER:PTN000622075
PomBase:SPAC24B11.06c
PomBase:SPBC119.08
PomBase:SPBC530.14c
RGD:3046
RGD:621506
RGD:628847
RGD:70500
RGD:70975
RGD:71050
SGD:S000000112
SGD:S000004103
SGD:S000004829
TAIR:locus:2024887
TAIR:locus:2124943
UniProtKB:A9T142
UniProtKB:O77306
UniProtKB:P28482
UniProtKB:P78362
UniProtKB:Q10N20
UniProtKB:Q13164
UniProtKB:Q96SB4
WB:WBGene00002178
WB:WBGene00002187
WB:WBGene00003048
WB:WBGene00003401
WB:WBGene00004056
WB:WBGene00004057

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003256
FB:FBgn0015765
MGI:MGI:1201387
MGI:MGI:1201408
MGI:MGI:1336881
MGI:MGI:1346347
MGI:MGI:1346858
MGI:MGI:1346859
MGI:MGI:1346861
MGI:MGI:1346865
MGI:MGI:1354946
MGI:MGI:1934157
MGI:MGI:2444559
MGI:MGI:96913
PANTHER:PTN000622075
PomBase:SPAC24B11.06c
PomBase:SPAC31G5.09c
PomBase:SPBC119.08
PomBase:SPBC530.14c
RGD:3046
RGD:3663
RGD:621505
RGD:621506
RGD:628675
RGD:628847
RGD:70496
RGD:70500
SGD:S000000112
SGD:S000001072
SGD:S000003272
SGD:S000003642
SGD:S000004103
TAIR:locus:2024887
TAIR:locus:2124943
UniProtKB:A9T142
UniProtKB:O77306
UniProtKB:P20794
UniProtKB:P28482
UniProtKB:P45983
UniProtKB:P78362
UniProtKB:Q10N20
UniProtKB:Q13164
UniProtKB:Q5AZN7
UniProtKB:Q8GYQ5
UniProtKB:Q96SB4
UniProtKB:Q9LV37
UniProtKB:Q9P419
WB:WBGene00002178
WB:WBGene00003048
WB:WBGene00003401
WB:WBGene00004055
WB:WBGene00004057
dictyBase:DDB_G0283903
dictyBase:DDB_G0286353

C

Seeded From UniProt

complete

protected

enables

GO:0004707

MAP kinase activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0015765
FB:FBgn0024846
FB:FBgn0267339
MGI:MGI:1346858
MGI:MGI:1346859
MGI:MGI:1346865
MGI:MGI:1354946
PANTHER:PTN001172432
PomBase:SPAC31G5.09c
PomBase:SPBC119.08
RGD:1309340
RGD:3045
RGD:3046
RGD:621505
RGD:70496
RGD:70500
RGD:70975
SGD:S000000112
SGD:S000003272
SGD:S000006258
UniProtKB:A0A1D8PFT5
UniProtKB:A0A1D8PT38
UniProtKB:O15264
UniProtKB:P27361
UniProtKB:Q15759
UniProtKB:Q16539
WB:WBGene00003401
WB:WBGene00004055
WB:WBGene00004056
dictyBase:DDB_G0286353

F

Seeded From UniProt

complete

protected

enables

GO:0004707

MAP kinase activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000183747
FB:FBgn0015765
FB:FBgn0024846
FB:FBgn0267339
MGI:MGI:1346858
MGI:MGI:1346859
MGI:MGI:1346865
MGI:MGI:1354946
PANTHER:PTN002372889
PomBase:SPAC31G5.09c
PomBase:SPBC119.08
RGD:1309340
RGD:3045
RGD:3046
RGD:621505
RGD:70496
RGD:70500
RGD:70975
SGD:S000000112
SGD:S000003272
SGD:S000006258
UniProtKB:A0A1D8PFT5
UniProtKB:A0A1D8PT38
UniProtKB:O15264
UniProtKB:P27361
UniProtKB:Q15759
UniProtKB:Q16539
WB:WBGene00003401
WB:WBGene00004055
WB:WBGene00004056
dictyBase:DDB_G0286353

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0045786

negative regulation of cell cycle

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:70975

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0045445

myoblast differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P53778

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0018105

peptidyl-serine phosphorylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P53778

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0006468

protein phosphorylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:70975

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:70975

C

Seeded From UniProt

complete

protected

enables

GO:0005524

ATP binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:70975

F

Seeded From UniProt

complete

protected

enables

GO:0004707

MAP kinase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:70975

F

Seeded From UniProt

complete

protected

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P53778

F

Seeded From UniProt

complete

protected

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:70975

F

Seeded From UniProt

complete

protected

enables

GO:0000287

magnesium ion binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P53778

F

Seeded From UniProt

complete

protected

involved_in

GO:0045445

myoblast differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P53778
ensembl:ENSP00000215659

P

Seeded From UniProt

complete

protected

involved_in

GO:0018105

peptidyl-serine phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P53778
ensembl:ENSP00000215659

P

Seeded From UniProt

complete

protected

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P53778
ensembl:ENSP00000215659

F

Seeded From UniProt

complete

protected

enables

GO:0000287

magnesium ion binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P53778
ensembl:ENSP00000215659

F

Seeded From UniProt

complete

protected

involved_in

GO:0045786

negative regulation of cell cycle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q63538
ensembl:ENSRNOP00000046455

P

Seeded From UniProt

complete

protected

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q63538
ensembl:ENSRNOP00000046455

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q63538
ensembl:ENSRNOP00000046455

C

Seeded From UniProt

complete

protected

enables

GO:0005524

ATP binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q63538
ensembl:ENSRNOP00000046455

F

Seeded From UniProt

complete

protected

enables

GO:0004707

MAP kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q63538
ensembl:ENSRNOP00000046455

F

Seeded From UniProt

complete

protected

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q63538
ensembl:ENSRNOP00000046455

F

Seeded From UniProt

complete

protected

involved_in

GO:0000165

MAPK cascade

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR038786

P

Seeded From UniProt

complete

protected

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719

F

Seeded From UniProt

complete

protected

enables

GO:0004707

MAP kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003527
InterPro:IPR008352
InterPro:IPR038786

F

Seeded From UniProt

complete

protected

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR003527
InterPro:IPR008352
InterPro:IPR017441

F

Seeded From UniProt

complete

protected

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR003527
InterPro:IPR008352

P

Seeded From UniProt

complete

protected

enables

GO:0004707

MAP kinase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.11.24

F

Seeded From UniProt

complete

protected

part_of

GO:0005654

nucleoplasm

Reactome:R-MMU-1605464

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005739

mitochondrion

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496
UniProtKB-SubCell:SL-0173

C

Seeded From UniProt

complete

protected

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

protected

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

protected

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

protected

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

protected

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

protected

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

protected

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

protected

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete




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