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HUMAN:PML

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0051607

defense response to virus

PMID:24407287

ECO:0000314

P

Figure 5: With a PML deficiency, induction of IL-1β by HSV-1 was markedly enhanced which may lead to inflammation.

complete
CACAO 9431

protected

enables

GO:0032183

SUMO binding

PMID:17081986

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P61956

F

Seeded From UniProt

complete

protected

involved_in

GO:0032206

positive regulation of telomere maintenance

PMID:26119943

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0000784

nuclear chromosome, telomeric region

PMID:26119943

ECO:0000314

direct assay evidence used in manual assertion

C

exists_during:(GO:0090399)

Seeded From UniProt

complete

protected

involved_in

GO:1902187

negative regulation of viral release from host cell

PMID:18248090

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045087

innate immune response

PMID:18248090

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0032183

SUMO binding

PMID:17081986

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P63165

F

Seeded From UniProt

complete

protected

enables

GO:0042803

protein homodimerization activity

PMID:9230084

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P29590

F

Seeded From UniProt

complete

protected

involved_in

GO:0034097

response to cytokine

PMID:9412458

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0016605

PML body

PMID:9412458

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0008285

negative regulation of cell population proliferation

PMID:12006491

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:9412458

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:2001238

positive regulation of extrinsic apoptotic signaling pathway

PMID:21803845

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:2000779

regulation of double-strand break repair

PMID:21639834

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:2000059

negative regulation of ubiquitin-dependent protein catabolic process

PMID:15195100

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0090398

cellular senescence

PMID:22117195

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0090398

cellular senescence

PMID:22002537

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0090398

cellular senescence

PMID:23431171

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:9448006

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

PMID:22406621

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0043153

entrainment of circadian clock by photoperiod

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q60953

P

Seeded From UniProt

complete

protected

involved_in

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q60953

P

Seeded From UniProt

complete

protected

involved_in

GO:0042752

regulation of circadian rhythm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q60953

P

Seeded From UniProt

complete

protected

part_of

GO:0042406

extrinsic component of endoplasmic reticulum membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q60953

C

Seeded From UniProt

complete

protected

involved_in

GO:0032922

circadian regulation of gene expression

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q60953

P

Seeded From UniProt

complete

protected

involved_in

GO:0032469

endoplasmic reticulum calcium ion homeostasis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q60953

P

Seeded From UniProt

complete

protected

enables

GO:0032183

SUMO binding

PMID:17081985

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P63165

F

Seeded From UniProt

complete

protected

enables

GO:0031625

ubiquitin protein ligase binding

PMID:12915590

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q00987

F

Seeded From UniProt

complete

protected

involved_in

GO:0030578

PML body organization

PMID:17081985

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0030308

negative regulation of cell growth

PMID:9448006

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0016605

PML body

PMID:15195100

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0016605

PML body

PMID:23431171

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0016605

PML body

PMID:22155184

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0016605

PML body

PMID:23007646

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0016605

PML body

PMID:22869143

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0016605

PML body

PMID:11331580

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0016605

PML body

PMID:17081985

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

colocalizes_with

GO:0016605

PML body

PMID:10910364

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0016605

PML body

PMID:9448006

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0016525

negative regulation of angiogenesis

PMID:16915281

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0010522

regulation of calcium ion transport into cytosol

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q60953

P

Seeded From UniProt

complete

protected

involved_in

GO:0006977

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q60953

P

Seeded From UniProt

complete

protected

involved_in

GO:0065003

protein-containing complex assembly

PMID:12915590

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0006355

regulation of transcription, DNA-templated

PMID:23007646

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q60953

C

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:18298799

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005730

nucleolus

PMID:15195100

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005654

nucleoplasm

PMID:12915590

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:22274616

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0001932

regulation of protein phosphorylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q60953

P

Seeded From UniProt

complete

protected

involved_in

GO:0001666

response to hypoxia

PMID:16915281

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:1902187

negative regulation of viral release from host cell

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104662
PANTHER:PTN002379290
UniProtKB:P29590

P

Seeded From UniProt

complete

protected

enables

GO:0046332

SMAD binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104662
PANTHER:PTN002379290

F

Seeded From UniProt

complete

protected

involved_in

GO:0045087

innate immune response

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104662
PANTHER:PTN002379290
UniProtKB:P29590

P

Seeded From UniProt

complete

protected

enables

GO:0032183

SUMO binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002379290
UniProtKB:P29590

F

Seeded From UniProt

complete

protected

involved_in

GO:0030578

PML body organization

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104662
PANTHER:PTN002379290
UniProtKB:P29590

P

Seeded From UniProt

complete

protected

part_of

GO:0016605

PML body

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104662
PANTHER:PTN002379290
UniProtKB:P29590

C

Seeded From UniProt

complete

protected

part_of

GO:0016363

nuclear matrix

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104662
PANTHER:PTN002379290
UniProtKB:P29590

C

Seeded From UniProt

complete

protected

involved_in

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104662
PANTHER:PTN002379290
UniProtKB:P29590

P

Seeded From UniProt

complete

protected

involved_in

GO:0007050

cell cycle arrest

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104662
PANTHER:PTN002379290
UniProtKB:P29590

P

Seeded From UniProt

complete

protected

involved_in

GO:0006355

regulation of transcription, DNA-templated

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104662
PANTHER:PTN002379290
UniProtKB:P29590

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002379290
UniProtKB:P29590

C

Seeded From UniProt

complete

protected

enables

GO:0003713

transcription coactivator activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002379290
UniProtKB:P29590

F

Seeded From UniProt

complete

protected

involved_in

GO:0051457

maintenance of protein location in nucleus

PMID:17332504

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0016605

PML body

PMID:12917339

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:1903508

positive regulation of nucleic acid-templated transcription

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0003713

P

Seeded From UniProt

complete

protected

involved_in

GO:0070059

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

P

Seeded From UniProt

complete

protected

involved_in

GO:0060444

branching involved in mammary gland duct morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

P

Seeded From UniProt

complete

protected

involved_in

GO:0050713

negative regulation of interleukin-1 beta secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

P

Seeded From UniProt

complete

protected

involved_in

GO:0050711

negative regulation of interleukin-1 secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

P

Seeded From UniProt

complete

protected

involved_in

GO:0048384

retinoic acid receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

P

Seeded From UniProt

complete

protected

involved_in

GO:0048146

positive regulation of fibroblast proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

P

Seeded From UniProt

complete

protected

enables

GO:0046332

SMAD binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

F

Seeded From UniProt

complete

protected

involved_in

GO:0045165

cell fate commitment

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

P

Seeded From UniProt

complete

protected

involved_in

GO:0045087

innate immune response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

P

Seeded From UniProt

complete

protected

involved_in

GO:0043153

entrainment of circadian clock by photoperiod

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

P

Seeded From UniProt

complete

protected

involved_in

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

P

Seeded From UniProt

complete

protected

involved_in

GO:0042752

regulation of circadian rhythm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

P

Seeded From UniProt

complete

protected

part_of

GO:0042406

extrinsic component of endoplasmic reticulum membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

C

Seeded From UniProt

complete

protected

involved_in

GO:0032922

circadian regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

P

Seeded From UniProt

complete

protected

involved_in

GO:0032469

endoplasmic reticulum calcium ion homeostasis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

P

Seeded From UniProt

complete

protected

involved_in

GO:0030578

PML body organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

P

Seeded From UniProt

complete

protected

involved_in

GO:0030155

regulation of cell adhesion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

P

Seeded From UniProt

complete

protected

involved_in

GO:0030099

myeloid cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

P

Seeded From UniProt

complete

protected

part_of

GO:0016605

PML body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

C

Seeded From UniProt

complete

protected

involved_in

GO:0016525

negative regulation of angiogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

P

Seeded From UniProt

complete

protected

part_of

GO:0016363

nuclear matrix

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

C

Seeded From UniProt

complete

protected

involved_in

GO:0010761

fibroblast migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

P

Seeded From UniProt

complete

protected

involved_in

GO:0010522

regulation of calcium ion transport into cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

P

Seeded From UniProt

complete

protected

involved_in

GO:0010332

response to gamma radiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

P

Seeded From UniProt

complete

protected

involved_in

GO:0009411

response to UV

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

P

Seeded From UniProt

complete

protected

involved_in

GO:0008631

intrinsic apoptotic signaling pathway in response to oxidative stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

P

Seeded From UniProt

complete

protected

involved_in

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

P

Seeded From UniProt

complete

protected

involved_in

GO:0008285

negative regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

P

Seeded From UniProt

complete

protected

involved_in

GO:0007569

cell aging

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

P

Seeded From UniProt

complete

protected

involved_in

GO:0007182

common-partner SMAD protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

P

Seeded From UniProt

complete

protected

involved_in

GO:0007179

transforming growth factor beta receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

P

Seeded From UniProt

complete

protected

involved_in

GO:0007050

cell cycle arrest

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

P

Seeded From UniProt

complete

protected

involved_in

GO:0006977

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

P

Seeded From UniProt

complete

protected

involved_in

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

P

Seeded From UniProt

complete

protected

involved_in

GO:0006606

protein import into nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

P

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

C

Seeded From UniProt

complete

protected

involved_in

GO:0001932

regulation of protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

P

Seeded From UniProt

complete

protected

involved_in

GO:0001666

response to hypoxia

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

P

Seeded From UniProt

complete

protected

part_of

GO:0000792

heterochromatin

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

C

Seeded From UniProt

complete

protected

involved_in

GO:2001235

positive regulation of apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

P

Seeded From UniProt

complete

protected

involved_in

GO:1990830

cellular response to leukemia inhibitory factor

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

P

Seeded From UniProt

complete

protected

involved_in

GO:1902187

negative regulation of viral release from host cell

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

P

Seeded From UniProt

complete

protected

involved_in

GO:0097191

extrinsic apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

P

Seeded From UniProt

complete

protected

involved_in

GO:0072332

intrinsic apoptotic signaling pathway by p53 class mediator

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

P

Seeded From UniProt

complete

protected

involved_in

GO:0071353

cellular response to interleukin-4

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60953
ensembl:ENSMUSP00000082816

P

Seeded From UniProt

complete

protected

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000315

F

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:16778193

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:9885291

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:16778193

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:16778193

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:16778193

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0002230

positive regulation of defense response to virus by host

PMID:16873256

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0046982

protein heterodimerization activity

PMID:7935403

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0045930

negative regulation of mitotic cell cycle

PMID:9395203

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:7935403

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0031965

nuclear membrane

PMID:16778193

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0030578

PML body organization

PMID:10779416

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0030308

negative regulation of cell growth

PMID:9583681

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0030308

negative regulation of cell growth

PMID:9395203

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0030308

negative regulation of cell growth

PMID:7935403

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007050

cell cycle arrest

PMID:9583681

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0006915

apoptotic process

PMID:9583681

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:16778193

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:9294197

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0050897

cobalt ion binding

PMID:7729428

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:22002537

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0030578

PML body organization

PMID:8643677

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0016605

PML body

PMID:9885291

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0008270

zinc ion binding

PMID:7729428

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0002230

positive regulation of defense response to virus by host

PMID:16873257

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:1904816

positive regulation of protein localization to chromosome, telomeric region

PMID:22641345

ECO:0000314

direct assay evidence used in manual assertion

P

transports_or_maintains_localization_of:(UniProtKB:Q06609)

Seeded From UniProt

complete

protected

involved_in

GO:0032206

positive regulation of telomere maintenance

PMID:22641345

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0060058

positive regulation of apoptotic process involved in mammary gland involution

PMID:11080164

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0050821

protein stabilization

PMID:12773567

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:11259576

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:9448006

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0032938

negative regulation of translation in response to oxidative stress

PMID:16915281

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0031065

positive regulation of histone deacetylation

PMID:11259576

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0030308

negative regulation of cell growth

PMID:9448006

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0016605

PML body

PMID:9448006

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0016363

nuclear matrix

PMID:11080164

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

PMID:12402044

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007050

cell cycle arrest

PMID:12773567

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0006605

protein targeting

PMID:15195100

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0006605

protein targeting

PMID:11080164

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:16778193

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005730

nucleolus

PMID:16778193

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0003713

transcription coactivator activity

PMID:11080164

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0003713

transcription coactivator activity

PMID:15626733

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0051974

negative regulation of telomerase activity

PMID:19567472

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0032211

negative regulation of telomere maintenance via telomerase

PMID:19567472

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:1903508

positive regulation of nucleic acid-templated transcription

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0003713

P

Seeded From UniProt

complete

protected

involved_in

GO:1903508

positive regulation of nucleic acid-templated transcription

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0003713

P

Seeded From UniProt

complete

protected

part_of

GO:0016605

PML body

PMID:9230084

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:1901796

regulation of signal transduction by p53 class mediator

Reactome:R-HSA-5633007

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0060333

interferon-gamma-mediated signaling pathway

Reactome:R-HSA-877300

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

Reactome:R-HSA-1031716

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-8938887
Reactome:R-HSA-6805638
Reactome:R-HSA-6805620
Reactome:R-HSA-5228508
Reactome:R-HSA-3000434
Reactome:R-HSA-3000433
Reactome:R-HSA-3000411
Reactome:R-HSA-3000383
Reactome:R-HSA-1031716

ECO:0000304

author statement supported by traceable reference used in manual assertion









C

Seeded From UniProt

complete

protected

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

protected

involved_in

GO:0051607

defense response to virus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0051

P

Seeded From UniProt

complete

protected

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

protected

involved_in

GO:0016032

viral process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0945

P

Seeded From UniProt

complete

protected

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

protected

involved_in

GO:0048511

rhythmic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0090

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

protected

involved_in

GO:0045087

innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0399

P

Seeded From UniProt

complete

protected

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0256

C

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

protected

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

protected

part_of

GO:0005768

endosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0967

C

Seeded From UniProt

complete

protected

part_of

GO:0031901

early endosome membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0093

C

Seeded From UniProt

complete

protected

part_of

GO:0016605

PML body

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0465

C

Seeded From UniProt

complete

protected

part_of

GO:0005730

nucleolus

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0188

C

Seeded From UniProt

complete

protected

part_of

GO:0005654

nucleoplasm

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0190

C

Seeded From UniProt

complete

protected

part_of

GO:0005789

endoplasmic reticulum membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0097

C

Seeded From UniProt

complete



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