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RAT:TGFB3

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

protected

involved_in

GO:0062009

secondary palate development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P17125

P

Seeded From UniProt

complete

protected

involved_in

GO:0060325

face morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10600

P

Seeded From UniProt

complete

protected

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10600

P

Seeded From UniProt

complete

protected

involved_in

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10600

P

Seeded From UniProt

complete

protected

part_of

GO:0031012

extracellular matrix

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10600

C

Seeded From UniProt

complete

protected

enables

GO:0034714

type III transforming growth factor beta receptor binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10600-2

F

Seeded From UniProt

complete

protected

involved_in

GO:0045216

cell-cell junction organization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10600

P

Seeded From UniProt

complete

protected

involved_in

GO:0043932

ossification involved in bone remodeling

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10600

P

Seeded From UniProt

complete

protected

enables

GO:0005114

type II transforming growth factor beta receptor binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10600-2

F

Seeded From UniProt

complete

protected

enables

GO:0050431

transforming growth factor beta binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10600

F

Seeded From UniProt

complete

protected

enables

GO:0042802

identical protein binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10600

F

Seeded From UniProt

complete

protected

enables

GO:0034714

type III transforming growth factor beta receptor binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10600

F

Seeded From UniProt

complete

protected

involved_in

GO:0032967

positive regulation of collagen biosynthetic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10600

P

Seeded From UniProt

complete

protected

enables

GO:0034713

type I transforming growth factor beta receptor binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10600

F

Seeded From UniProt

complete

protected

enables

GO:0005114

type II transforming growth factor beta receptor binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10600

F

Seeded From UniProt

complete

protected

involved_in

GO:0032570

response to progesterone

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10600

P

Seeded From UniProt

complete

protected

involved_in

GO:0030501

positive regulation of bone mineralization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10600

P

Seeded From UniProt

complete

protected

involved_in

GO:0010936

negative regulation of macrophage cytokine production

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10600

P

Seeded From UniProt

complete

protected

involved_in

GO:0010718

positive regulation of epithelial to mesenchymal transition

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10600

P

Seeded From UniProt

complete

protected

involved_in

GO:0008285

negative regulation of cell population proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10600

P

Seeded From UniProt

complete

protected

involved_in

GO:0007435

salivary gland morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10600

P

Seeded From UniProt

complete

protected

involved_in

GO:0007179

transforming growth factor beta receptor signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10600

P

Seeded From UniProt

complete

protected

involved_in

GO:0001666

response to hypoxia

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10600

P

Seeded From UniProt

complete

protected

involved_in

GO:0070483

detection of hypoxia

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10600

P

Seeded From UniProt

complete

protected

involved_in

GO:0060364

frontal suture morphogenesis

PMID:12416537

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0048839

inner ear development

PMID:16479080

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0048702

embryonic neurocranium morphogenesis

PMID:11002343

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0048565

digestive tract development

PMID:12815632

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0046982

protein heterodimerization activity

PMID:18406405

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0043627

response to estrogen

PMID:14605008

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0043065

positive regulation of apoptotic process

PMID:16532270

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0043065

positive regulation of apoptotic process

PMID:11002343

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0043025

neuronal cell body

PMID:15214860

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0042060

wound healing

PMID:18205704

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0034616

response to laminar fluid shear stress

PMID:16217485

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

PMID:12071374

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0030324

lung development

PMID:7852342

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0030315

T-tubule

PMID:9281452

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0030141

secretory granule

PMID:15214860

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0009986

cell surface

PMID:16479080

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0008285

negative regulation of cell population proliferation

PMID:11002343

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007568

aging

PMID:12051734

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007565

female pregnancy

PMID:15927076

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:9281452

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:9281452

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

PMID:16891311

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0001666

response to hypoxia

PMID:14697406

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0000187

activation of MAPK activity

PMID:14605008

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0060395

SMAD protein signal transduction

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1338027
MGI:MGI:88180
MGI:MGI:88182
MGI:MGI:95689
MGI:MGI:97359
PANTHER:PTN000218063
UniProtKB:O95390
UniProtKB:P12643
UniProtKB:P12644
UniProtKB:P18075
UniProtKB:P22004
UniProtKB:P43026
UniProtKB:P61812
UniProtKB:Q6KF10
UniProtKB:Q99988

P

Seeded From UniProt

complete

protected

involved_in

GO:0048468

cell development

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103302
PANTHER:PTN000218063

P

Seeded From UniProt

complete

protected

involved_in

GO:0043408

regulation of MAPK cascade

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107335
PANTHER:PTN000218063

P

Seeded From UniProt

complete

protected

involved_in

GO:0042981

regulation of apoptotic process

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98726
PANTHER:PTN000218063

P

Seeded From UniProt

complete

protected

involved_in

GO:0042127

regulation of cell population proliferation

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98725
PANTHER:PTN000218722

P

Seeded From UniProt

complete

protected

involved_in

GO:0010862

positive regulation of pathway-restricted SMAD protein phosphorylation

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107335
MGI:MGI:1338820
MGI:MGI:88182
MGI:MGI:95684
MGI:MGI:98727
PANTHER:PTN000218063
UniProtKB:O95393
UniProtKB:P01137
UniProtKB:P08476
UniProtKB:P12643
UniProtKB:P12644
UniProtKB:P18075
UniProtKB:P22003
UniProtKB:P22004
UniProtKB:Q6KF10
UniProtKB:Q7Z4P5
UniProtKB:Q96S42
UniProtKB:Q9UK05

P

Seeded From UniProt

complete

protected

involved_in

GO:0007179

transforming growth factor beta receptor signaling pathway

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98725
PANTHER:PTN000218722
UniProtKB:P01137
UniProtKB:P10600
UniProtKB:P61812

P

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000490
MGI:MGI:103302
MGI:MGI:1338027
MGI:MGI:88177
MGI:MGI:88180
MGI:MGI:95691
MGI:MGI:98725
MGI:MGI:98726
PANTHER:PTN000218063
RGD:1305979
RGD:2211
RGD:2212
RGD:2213
RGD:2214
RGD:2912
RGD:2913
RGD:3115
RGD:3851
RGD:62074
RGD:620743
RGD:621512
RGD:69051
RGD:70491
UniProtKB:O14793
UniProtKB:O42220
UniProtKB:O95393
UniProtKB:P01137
UniProtKB:P12643
UniProtKB:P12644
UniProtKB:P18075
UniProtKB:P30371
UniProtKB:P61812
UniProtKB:Q96S42
UniProtKB:Q99988
WB:WBGene00000903

C

Seeded From UniProt

complete

protected

enables

GO:0005160

transforming growth factor beta receptor binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98725
PANTHER:PTN000218063
UniProtKB:P61812

F

Seeded From UniProt

complete

protected

enables

GO:0005125

cytokine activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000218063
UniProtKB:P08476
UniProtKB:P12644

F

Seeded From UniProt

complete

protected

enables

GO:0005114

type II transforming growth factor beta receptor binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000218722
UniProtKB:P01137
UniProtKB:P10600
UniProtKB:P61812

F

Seeded From UniProt

complete

protected

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

protected

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

protected

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

protected

part_of

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A5YM40
ensembl:ENSP00000238682

C

Seeded From UniProt

complete

protected

enables

GO:0034714

type III transforming growth factor beta receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A5YM40
ensembl:ENSP00000238682

F

Seeded From UniProt

complete

protected

enables

GO:0005114

type II transforming growth factor beta receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A5YM40
ensembl:ENSP00000238682

F

Seeded From UniProt

complete

protected

involved_in

GO:1905075

positive regulation of tight junction disassembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10600
ensembl:ENSP00000238682

P

Seeded From UniProt

complete

protected

involved_in

GO:1904706

negative regulation of vascular smooth muscle cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10600
ensembl:ENSP00000238682

P

Seeded From UniProt

complete

protected

involved_in

GO:0070483

detection of hypoxia

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10600
ensembl:ENSP00000238682

P

Seeded From UniProt

complete

protected

part_of

GO:0062023

collagen-containing extracellular matrix

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10600
ensembl:ENSP00000238682

C

Seeded From UniProt

complete

protected

involved_in

GO:0060325

face morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10600
ensembl:ENSP00000238682

P

Seeded From UniProt

complete

protected

involved_in

GO:0051496

positive regulation of stress fiber assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10600
ensembl:ENSP00000238682

P

Seeded From UniProt

complete

protected

involved_in

GO:0050714

positive regulation of protein secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10600
ensembl:ENSP00000238682

P

Seeded From UniProt

complete

protected

enables

GO:0050431

transforming growth factor beta binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10600
ensembl:ENSP00000238682

F

Seeded From UniProt

complete

protected

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10600
ensembl:ENSP00000238682

P

Seeded From UniProt

complete

protected

involved_in

GO:0045216

cell-cell junction organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10600
ensembl:ENSP00000238682

P

Seeded From UniProt

complete

protected

involved_in

GO:0043932

ossification involved in bone remodeling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10600
ensembl:ENSP00000238682

P

Seeded From UniProt

complete

protected

part_of

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10600
ensembl:ENSP00000238682

C

Seeded From UniProt

complete

protected

enables

GO:0042802

identical protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10600
ensembl:ENSP00000238682

F

Seeded From UniProt

complete

protected

enables

GO:0034714

type III transforming growth factor beta receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10600
ensembl:ENSP00000238682

F

Seeded From UniProt

complete

protected

enables

GO:0034713

type I transforming growth factor beta receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10600
ensembl:ENSP00000238682

F

Seeded From UniProt

complete

protected

involved_in

GO:0032967

positive regulation of collagen biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10600
ensembl:ENSP00000238682

P

Seeded From UniProt

complete

protected

involved_in

GO:0032570

response to progesterone

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10600
ensembl:ENSP00000238682

P

Seeded From UniProt

complete

protected

involved_in

GO:0030501

positive regulation of bone mineralization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10600
ensembl:ENSP00000238682

P

Seeded From UniProt

complete

protected

involved_in

GO:0010936

negative regulation of macrophage cytokine production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10600
ensembl:ENSP00000238682

P

Seeded From UniProt

complete

protected

involved_in

GO:0010718

positive regulation of epithelial to mesenchymal transition

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10600
ensembl:ENSP00000238682

P

Seeded From UniProt

complete

protected

involved_in

GO:0008285

negative regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10600
ensembl:ENSP00000238682

P

Seeded From UniProt

complete

protected

involved_in

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10600
ensembl:ENSP00000238682

P

Seeded From UniProt

complete

protected

involved_in

GO:0007435

salivary gland morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10600
ensembl:ENSP00000238682

P

Seeded From UniProt

complete

protected

involved_in

GO:0007179

transforming growth factor beta receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10600
ensembl:ENSP00000238682

P

Seeded From UniProt

complete

protected

enables

GO:0005114

type II transforming growth factor beta receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10600
ensembl:ENSP00000238682

F

Seeded From UniProt

complete

protected

involved_in

GO:0001666

response to hypoxia

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10600
ensembl:ENSP00000238682

P

Seeded From UniProt

complete

protected

enables

GO:0005160

transforming growth factor beta receptor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015618

F

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016319

C

Seeded From UniProt

complete

protected

enables

GO:0008083

growth factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001839
InterPro:IPR017948

F

Seeded From UniProt

complete

protected

involved_in

GO:0050678

regulation of epithelial cell proliferation

PMID:12183510

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045601

regulation of endothelial cell differentiation

PMID:12183510

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0030856

regulation of epithelial cell differentiation

PMID:12183510

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0005160

transforming growth factor beta receptor binding

PMID:7852342

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

protected

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

protected

involved_in

GO:0051781

positive regulation of cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0497

P

Seeded From UniProt

complete

protected

enables

GO:0008083

growth factor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0339

F

Seeded From UniProt

complete




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