GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com


Jump to: navigation, search


You don't have sufficient rights on this wiki to edit tables. Perhaps you need to log in. Changes you make in the Table editor will not be saved back to the wiki

See Help for Help on this wiki. See the documentation for how to use the table editor


Mao, W, Yu, XX, Zhong, A, Li, W, Brush, J, Sherwood, SW, Adams, SH and Pan, G (1999) UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells. FEBS Lett. 443:326-30


Uncoupling proteins (UCPs) are a family of mitochondrial transporter proteins that have been implicated in thermoregulatory heat production and maintenance of the basal metabolic rate. We have identified and partially characterized a novel member of the human uncoupling protein family, termed uncoupling protein-4 (UCP4). Protein sequence analyses showed that UCP4 is most related to UCP3 and possesses features characteristic of mitochondrial transporter proteins. Unlike other known UCPs, UCP4 transcripts are exclusively expressed in both fetal and adult brain tissues. UCP4 maps to human chromosome 6p11.2-q12. Consistent with its potential role as an uncoupling protein, UCP4 is localized to the mitochondria and its ectopic expression in mammalian cells reduces mitochondrial membrane potential. These findings suggest that UCP4 may be involved in thermoregulatory heat production and metabolism in the brain.




Amino Acid Sequence; Animals; Brain/embryology; Brain/metabolism; Carbonyl Cyanide m-Chlorophenyl Hydrazone/pharmacology; Carrier Proteins/analysis; Carrier Proteins/chemistry; Carrier Proteins/genetics; Carrier Proteins/physiology; Cell Line; Cell Survival; Chromosome Mapping; Chromosomes, Human, Pair 6/genetics; Cloning, Molecular; Expressed Sequence Tags; Genes, Plant/genetics; Humans; Ion Channels; Membrane Potentials/drug effects; Membrane Transport Proteins; Mitochondria/metabolism; Mitochondria/physiology; Mitochondrial Proteins; Molecular Sequence Data; Organ Specificity; RNA, Messenger/analysis; Sequence Homology, Amino Acid; Transfection; Tumor Cells, Cultured