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HUMAN:VGFR2

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0004716

receptor signaling protein tyrosine kinase activity

PMID:23139789

ECO:0000314

F

Figure one shows that 'HUVECs were subjected to geldanamycin (17-DMAG) treatment for indicated times, lysed and processed for immunoblotting (IB) to analyze indicated protein levels. Arrowhead indicates mature VEGFR2; TfR, transferrin receptor. (B) Quantification of mature VEGFR2 levels in control and geldanamycin-treated endothelial cells'

complete
CACAO 5697

protected

involved_in

GO:0045766

positive regulation of angiogenesis

PMID:28637396

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0002618)

Seeded From UniProt

complete

protected

involved_in

GO:0090050

positive regulation of cell migration involved in sprouting angiogenesis

PMID:18977327

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:2000044)

Seeded From UniProt

complete

protected

enables

GO:0045296

cadherin binding

PMID:25893857

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P33151

F

Seeded From UniProt

complete

protected

enables

GO:0005178

integrin binding

PMID:30873824

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P20702

F

Seeded From UniProt

complete

protected

involved_in

GO:0043536

positive regulation of blood vessel endothelial cell migration

PMID:26879375

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0010629

negative regulation of gene expression

PMID:26879375

ECO:0000314

direct assay evidence used in manual assertion

P

  • regulates_expression_of:(ENSEMBL:ENSG00000207821)
  • part_of:(GO:1904881)

Seeded From UniProt

complete

protected

involved_in

GO:1904881

cellular response to hydrogen sulfide

PMID:26879375

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045766

positive regulation of angiogenesis

PMID:26879375

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0000071)

Seeded From UniProt

complete

protected

involved_in

GO:0070371

ERK1 and ERK2 cascade

PMID:24863063

ECO:0000315

mutant phenotype evidence used in manual assertion

P

part_of:(GO:0038190)

Seeded From UniProt

complete

protected

involved_in

GO:0043491

protein kinase B signaling

PMID:24863063

ECO:0000315

mutant phenotype evidence used in manual assertion

P

part_of:(GO:0038190)

Seeded From UniProt

complete

protected

involved_in

GO:0038033

positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway

PMID:21885851

ECO:0000314

direct assay evidence used in manual assertion

P

results_in_movement_of:(CL:0002543)

Seeded From UniProt

complete

protected

involved_in

GO:0035924

cellular response to vascular endothelial growth factor stimulus

PMID:23529610

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0048010

vascular endothelial growth factor receptor signaling pathway

PMID:23529610

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005783

endoplasmic reticulum

PMID:23529610

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0097443

sorting endosome

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P35918

C

Seeded From UniProt

complete

protected

involved_in

GO:0051894

positive regulation of focal adhesion assembly

PMID:12820653

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0050927

positive regulation of positive chemotaxis

PMID:7929439

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0038083

peptidyl-tyrosine autophosphorylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P35918

P

Seeded From UniProt

complete

protected

involved_in

GO:0030335

positive regulation of cell migration

PMID:7929439

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0019838

growth factor binding

PMID:10022831

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P15692

F

Seeded From UniProt

complete

protected

enables

GO:0019838

growth factor binding

PMID:1417831

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P15692

F

Seeded From UniProt

complete

protected

involved_in

GO:0010595

positive regulation of endothelial cell migration

PMID:10022831

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0008360

regulation of cell shape

PMID:7929439

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0008284

positive regulation of cell population proliferation

PMID:7929439

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P35918

C

Seeded From UniProt

complete

protected

part_of

GO:0005769

early endosome

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P35918

C

Seeded From UniProt

complete

protected

enables

GO:0005178

integrin binding

PMID:10022831

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P05106

F

Seeded From UniProt

complete

protected

enables

GO:0005021

vascular endothelial growth factor-activated receptor activity

PMID:10022831

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0005021

vascular endothelial growth factor-activated receptor activity

PMID:1417831

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0002042

cell migration involved in sprouting angiogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P35918

P

Seeded From UniProt

complete

protected

involved_in

GO:0001938

positive regulation of endothelial cell proliferation

PMID:10022831

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:2001214

positive regulation of vasculogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P35918

P

Seeded From UniProt

complete

protected

involved_in

GO:2000352

negative regulation of endothelial cell apoptotic process

PMID:9804796

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0070374

positive regulation of ERK1 and ERK2 cascade

PMID:15215251

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0051770

positive regulation of nitric-oxide synthase biosynthetic process

PMID:9837777

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0051770

positive regulation of nitric-oxide synthase biosynthetic process

PMID:10600473

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0048010

vascular endothelial growth factor receptor signaling pathway

PMID:15215251

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0048010

vascular endothelial growth factor receptor signaling pathway

PMID:11387210

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0048010

vascular endothelial growth factor receptor signaling pathway

PMID:10102632

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0046777

protein autophosphorylation

PMID:10102632

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0046777

protein autophosphorylation

PMID:10037737

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0046777

protein autophosphorylation

PMID:19033661

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045766

positive regulation of angiogenesis

PMID:15215251

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0045121

membrane raft

PMID:23262137

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0043410

positive regulation of MAPK cascade

PMID:11387210

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0043066

negative regulation of apoptotic process

PMID:15215251

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0035924

cellular response to vascular endothelial growth factor stimulus

PMID:15215251

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0035924

cellular response to vascular endothelial growth factor stimulus

PMID:11387210

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0035924

cellular response to vascular endothelial growth factor stimulus

PMID:10102632

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0035924

cellular response to vascular endothelial growth factor stimulus

PMID:19033661

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0035584

calcium-mediated signaling using intracellular calcium source

PMID:15215251

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0035162

embryonic hemopoiesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P35918

P

Seeded From UniProt

complete

protected

involved_in

GO:0030335

positive regulation of cell migration

PMID:15215251

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0030054

cell junction

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P35918

C

Seeded From UniProt

complete

protected

involved_in

GO:0018108

peptidyl-tyrosine phosphorylation

PMID:10102632

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0018108

peptidyl-tyrosine phosphorylation

PMID:10037737

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0014068

positive regulation of phosphatidylinositol 3-kinase signaling

PMID:9804796

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0008284

positive regulation of cell population proliferation

PMID:15215251

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005887

integral component of plasma membrane

PMID:10102632

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

PMID:23262137

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000115)

Seeded From UniProt

complete

protected

part_of

GO:0005794

Golgi apparatus

PMID:23262137

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005768

endosome

PMID:23262137

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0005021

vascular endothelial growth factor-activated receptor activity

PMID:15215251

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0005021

vascular endothelial growth factor-activated receptor activity

PMID:11387210

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0005021

vascular endothelial growth factor-activated receptor activity

PMID:10102632

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0004713

protein tyrosine kinase activity

PMID:10037737

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0003158

endothelium development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P35918

P

Seeded From UniProt

complete

protected

involved_in

GO:0001938

positive regulation of endothelial cell proliferation

PMID:11387210

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0001934

positive regulation of protein phosphorylation

PMID:19033661

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0001570

vasculogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P35918

P

Seeded From UniProt

complete

protected

involved_in

GO:0070374

positive regulation of ERK1 and ERK2 cascade

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1339758
MGI:MGI:97531
PANTHER:PTN001230896
UniProtKB:P09619
UniProtKB:P16234
UniProtKB:P35916
UniProtKB:P35968

P

Seeded From UniProt

complete

protected

involved_in

GO:0048010

vascular endothelial growth factor receptor signaling pathway

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95558
MGI:MGI:96683
PANTHER:PTN002814439
RGD:2965
RGD:621737
UniProtKB:P17948
UniProtKB:P35916
UniProtKB:P35968
ZFIN:ZDB-GENE-980526-326

P

Seeded From UniProt

complete

protected

involved_in

GO:0045766

positive regulation of angiogenesis

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:96683
PANTHER:PTN002814441
RGD:2965
UniProtKB:P35968

P

Seeded From UniProt

complete

protected

involved_in

GO:0045446

endothelial cell differentiation

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:96683
PANTHER:PTN002814441

P

Seeded From UniProt

complete

protected

involved_in

GO:0043410

positive regulation of MAPK cascade

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003733
MGI:MGI:1339758
MGI:MGI:96677
MGI:MGI:97531
PANTHER:PTN001230896
RGD:2621
UniProtKB:P09619
UniProtKB:P10721
UniProtKB:P16234
UniProtKB:P17948
UniProtKB:P35916
UniProtKB:P35968

P

Seeded From UniProt

complete

protected

part_of

GO:0043235

receptor complex

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0015380
FB:FBgn0024245
FB:FBgn0033791
PANTHER:PTN002356460
UniProtKB:A6QR62
UniProtKB:O15146
UniProtKB:P00533
UniProtKB:P04626
UniProtKB:P04629
UniProtKB:P06213
UniProtKB:P07949
UniProtKB:P08069
UniProtKB:P11362
UniProtKB:P14616
UniProtKB:P17948
UniProtKB:P21860
UniProtKB:P35916
UniProtKB:Q01973
UniProtKB:Q08345
UniProtKB:Q15303
UniProtKB:Q16288
UniProtKB:Q16620

C

Seeded From UniProt

complete

protected

enables

GO:0038085

vascular endothelial growth factor binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001974926
UniProtKB:P35968

F

Seeded From UniProt

complete

protected

involved_in

GO:0016477

cell migration

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:96683
PANTHER:PTN002814441

P

Seeded From UniProt

complete

protected

involved_in

GO:0014068

positive regulation of phosphatidylinositol 3-kinase signaling

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002814439
RGD:2965
UniProtKB:P17948
UniProtKB:P35968

P

Seeded From UniProt

complete

protected

involved_in

GO:0008284

positive regulation of cell population proliferation

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1339758
MGI:MGI:95561
MGI:MGI:96677
MGI:MGI:96683
MGI:MGI:97531
PANTHER:PTN001230896
RGD:2621
RGD:2965
RGD:3284
RGD:3285
RGD:620568
UniProtKB:P07333
UniProtKB:P09619
UniProtKB:P16234
UniProtKB:P35916
UniProtKB:P35968

P

Seeded From UniProt

complete

protected

involved_in

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003366
FB:FBgn0003731
FB:FBgn0003733
FB:FBgn0283499
MGI:MGI:104757
MGI:MGI:109378
MGI:MGI:1096337
MGI:MGI:1339758
MGI:MGI:1345277
MGI:MGI:95276
MGI:MGI:95278
MGI:MGI:95294
MGI:MGI:95522
MGI:MGI:95523
MGI:MGI:95524
MGI:MGI:95525
MGI:MGI:95558
MGI:MGI:95561
MGI:MGI:96575
MGI:MGI:96677
MGI:MGI:96683
MGI:MGI:96969
MGI:MGI:97384
MGI:MGI:97530
MGI:MGI:97531
MGI:MGI:97902
MGI:MGI:98277
MGI:MGI:99216
MGI:MGI:99611
MGI:MGI:99612
MGI:MGI:99654
PANTHER:PTN002356460
RGD:2543
RGD:2611
RGD:2612
RGD:2621
RGD:2869
RGD:2917
RGD:2965
RGD:3082
RGD:3213
RGD:3214
RGD:3284
RGD:3285
RGD:620144
RGD:620714
RGD:620831
RGD:621737
RGD:69323
UniProtKB:A6QR62
UniProtKB:P00533
UniProtKB:P04626
UniProtKB:P04629
UniProtKB:P06213
UniProtKB:P07949
UniProtKB:P08069
UniProtKB:P09619
UniProtKB:P10721
UniProtKB:P11362
UniProtKB:P16234
UniProtKB:P17948
UniProtKB:P21709
UniProtKB:P21802
UniProtKB:P22455
UniProtKB:P22607
UniProtKB:P29317
UniProtKB:P29320
UniProtKB:P35916
UniProtKB:P35968
UniProtKB:P54753
UniProtKB:P54760
UniProtKB:P54762
UniProtKB:P54764
UniProtKB:Q02763
UniProtKB:Q08345
UniProtKB:Q15303
UniProtKB:Q15375
UniProtKB:Q16288
UniProtKB:Q16620
UniProtKB:Q16832
UniProtKB:Q5JZY3
UniProtKB:Q91987
WB:WBGene00001184
WB:WBGene00006868
ZFIN:ZDB-GENE-020503-1
ZFIN:ZDB-GENE-020503-2
ZFIN:ZDB-GENE-060503-14
ZFIN:ZDB-GENE-070713-2
ZFIN:ZDB-GENE-980526-255
ZFIN:ZDB-GENE-980526-326
ZFIN:ZDB-GENE-990415-62

P

Seeded From UniProt

complete

protected

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003366
FB:FBgn0003731
FB:FBgn0003733
FB:FBgn0011829
FB:FBgn0015380
FB:FBgn0032006
FB:FBgn0283499
MGI:MGI:103581
MGI:MGI:104771
MGI:MGI:109378
MGI:MGI:98277
MGI:MGI:99611
PANTHER:PTN002356460
RGD:1560587
RGD:3213
RGD:3214
RGD:70957
UniProtKB:P04629
UniProtKB:P06213
UniProtKB:P07949
UniProtKB:P16234
UniProtKB:P17948
UniProtKB:P21709
UniProtKB:P21802
UniProtKB:P22455
UniProtKB:P22607
UniProtKB:P29317
UniProtKB:P29320
UniProtKB:P35968
UniProtKB:P54753
UniProtKB:P54760
UniProtKB:P54762
UniProtKB:Q02763
UniProtKB:Q16620
UniProtKB:Q9UM73
WB:WBGene00000289
WB:WBGene00000898

C

Seeded From UniProt

complete

protected

enables

GO:0005021

vascular endothelial growth factor-activated receptor activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95558
MGI:MGI:95561
MGI:MGI:96683
PANTHER:PTN001974926
RGD:2621
RGD:2965
RGD:621737
UniProtKB:P17948
UniProtKB:P35916
UniProtKB:P35968

F

Seeded From UniProt

complete

protected

enables

GO:0004714

transmembrane receptor protein tyrosine kinase activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003733
FB:FBgn0040505
FB:FBgn0283499
MGI:MGI:109378
MGI:MGI:1339758
MGI:MGI:1345277
MGI:MGI:95276
MGI:MGI:95294
MGI:MGI:95522
MGI:MGI:95524
MGI:MGI:95558
MGI:MGI:95561
MGI:MGI:96677
MGI:MGI:96683
MGI:MGI:96969
MGI:MGI:97384
MGI:MGI:97530
MGI:MGI:97902
MGI:MGI:98277
MGI:MGI:99611
MGI:MGI:99612
MGI:MGI:99654
PANTHER:PTN002356460
RGD:2543
RGD:2611
RGD:2621
RGD:2869
RGD:2917
RGD:2965
RGD:3082
RGD:3213
RGD:3214
RGD:3284
RGD:3285
RGD:620144
RGD:620714
RGD:620831
RGD:621737
UniProtKB:P00533
UniProtKB:P04626
UniProtKB:P04629
UniProtKB:P06213
UniProtKB:P07333
UniProtKB:P07949
UniProtKB:P08069
UniProtKB:P09619
UniProtKB:P10721
UniProtKB:P11362
UniProtKB:P14616
UniProtKB:P16234
UniProtKB:P17948
UniProtKB:P21709
UniProtKB:P21802
UniProtKB:P22455
UniProtKB:P22607
UniProtKB:P29317
UniProtKB:P29320
UniProtKB:P35916
UniProtKB:P35968
UniProtKB:P54753
UniProtKB:P54760
UniProtKB:P54762
UniProtKB:Q08345
UniProtKB:Q15303
UniProtKB:Q16620
UniProtKB:Q16832
UniProtKB:Q5JZY3
UniProtKB:Q91987
UniProtKB:Q9UM73
WB:WBGene00000289
WB:WBGene00006868
WB:WBGene00020504
ZFIN:ZDB-GENE-980526-255

F

Seeded From UniProt

complete

protected

involved_in

GO:0002040

sprouting angiogenesis

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95558
MGI:MGI:95561
MGI:MGI:96683
PANTHER:PTN001562281
ZFIN:ZDB-GENE-000705-1
ZFIN:ZDB-GENE-050407-1
ZFIN:ZDB-GENE-980526-326

P

Seeded From UniProt

complete

protected

enables

GO:0004713

protein tyrosine kinase activity

PMID:9398617

ECO:0000269

experimental evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0004713

protein tyrosine kinase activity

PMID:7999104

ECO:0000269

experimental evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0004713

protein tyrosine kinase activity

PMID:15962004

ECO:0000269

experimental evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0004713

protein tyrosine kinase activity

PMID:10037737

ECO:0000269

experimental evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0090141

positive regulation of mitochondrial fission

PMID:23798385

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P07585

P

Seeded From UniProt

complete

protected

involved_in

GO:0051901

positive regulation of mitochondrial depolarization

PMID:23798385

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P07585

P

Seeded From UniProt

complete

protected

involved_in

GO:0016239

positive regulation of macroautophagy

PMID:23798385

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P07585

P

Seeded From UniProt

complete

protected

enables

GO:0042802

identical protein binding

PMID:20660291

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P35968

F

Seeded From UniProt

complete

protected

enables

GO:0042802

identical protein binding

PMID:20080685

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P35968

F

Seeded From UniProt

complete

protected

enables

GO:0042802

identical protein binding

PMID:17293873

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P35968

F

Seeded From UniProt

complete

protected

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR001245
InterPro:IPR008266

F

Seeded From UniProt

complete

protected

enables

GO:0004713

protein tyrosine kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR020635

F

Seeded From UniProt

complete

protected

enables

GO:0004714

transmembrane receptor protein tyrosine kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001824

F

Seeded From UniProt

complete

protected

enables

GO:0005021

vascular endothelial growth factor-activated receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR009136

F

Seeded From UniProt

complete

protected

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR001824
InterPro:IPR009136
InterPro:IPR017441

F

Seeded From UniProt

complete

protected

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR001245
InterPro:IPR001824
InterPro:IPR008266
InterPro:IPR009136
InterPro:IPR020635

P

Seeded From UniProt

complete

protected

involved_in

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001824

P

Seeded From UniProt

complete

protected

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR009136

C

Seeded From UniProt

complete

protected

enables

GO:0019838

growth factor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR009136

F

Seeded From UniProt

complete

protected

involved_in

GO:0048010

vascular endothelial growth factor receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR009136

P

Seeded From UniProt

complete

protected

enables

GO:0004714

transmembrane receptor protein tyrosine kinase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.10.1

F

Seeded From UniProt

complete

protected

enables

GO:0038085

vascular endothelial growth factor binding

PMID:20660291

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P15692

F

Seeded From UniProt

complete

protected

involved_in

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

PMID:1417831

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005887

integral component of plasma membrane

PMID:1656371

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0051879

Hsp90 protein binding

PMID:19267251

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0004714

transmembrane receptor protein tyrosine kinase activity

PMID:1417831

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0001525

angiogenesis

PMID:10022831

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0048010

vascular endothelial growth factor receptor signaling pathway

Reactome:R-HSA-194313
Reactome:R-HSA-194138

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

protected

involved_in

GO:0030198

extracellular matrix organization

Reactome:R-HSA-1474244

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-5357479
Reactome:R-HSA-5357432
Reactome:R-HSA-5357429
Reactome:R-HSA-5218854
Reactome:R-HSA-5218851
Reactome:R-HSA-5218847
Reactome:R-HSA-5218839
Reactome:R-HSA-5218838
Reactome:R-HSA-5218836
Reactome:R-HSA-5218832
Reactome:R-HSA-5218830
Reactome:R-HSA-5218826
Reactome:R-HSA-5218824
Reactome:R-HSA-5218822
Reactome:R-HSA-5218820
Reactome:R-HSA-5218819
Reactome:R-HSA-5218818
Reactome:R-HSA-5218815
Reactome:R-HSA-5218814
Reactome:R-HSA-5218812
Reactome:R-HSA-5218811
Reactome:R-HSA-5218809
Reactome:R-HSA-5218806
Reactome:R-HSA-5218804
Reactome:R-HSA-5218645
Reactome:R-HSA-5218643
Reactome:R-HSA-5218642
Reactome:R-HSA-5218640
Reactome:R-HSA-4420206
Reactome:R-HSA-4420202
Reactome:R-HSA-4420153
Reactome:R-HSA-4420143
Reactome:R-HSA-4420140
Reactome:R-HSA-4420128
Reactome:R-HSA-4420121
Reactome:R-HSA-4420117
Reactome:R-HSA-4420107
Reactome:R-HSA-4420099
Reactome:R-HSA-4420083
Reactome:R-HSA-4088281
Reactome:R-HSA-195408
Reactome:R-HSA-194310

ECO:0000304

author statement supported by traceable reference used in manual assertion










































C

Seeded From UniProt

complete

protected

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

protected

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

protected

part_of

GO:0031410

cytoplasmic vesicle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0968

C

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

protected

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

protected

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

protected

enables

GO:0004713

protein tyrosine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0829

F

Seeded From UniProt

complete

protected

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0256
UniProtKB-SubCell:SL-0095

C

Seeded From UniProt

complete

protected

involved_in

GO:0001525

angiogenesis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0037

P

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

protected

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

protected

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

protected

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

protected

part_of

GO:0030054

cell junction

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0965
UniProtKB-SubCell:SL-0038

C

Seeded From UniProt

complete

protected

involved_in

GO:0016032

viral process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0945

P

Seeded From UniProt

complete

protected

part_of

GO:0005768

endosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0967

C

Seeded From UniProt

complete

protected

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

protected

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

protected

part_of

GO:0005769

early endosome

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0094

C

Seeded From UniProt

complete



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