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HUMAN:CXL10

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:1901509

regulation of endothelial tube morphogenesis

PMID:16484616

ECO:0000314

P

Fig 1A/1B shows that when incubated with CXCL10, human adult dermal microvascular cells do not form as many of the tubes needed for angiogenesis as the control group without CXCL10 does.

complete
CACAO 5329

public

GO:0010596

negative regulation of endothelial cell migration

PMID:16484616

ECO:0000314

P

Fig 2A shows a significant drop in the migration of the HMEC-1 cells in the presence of CXCL10.

complete
CACAO 5335

public

GO:0010819

regulation of T cell chemotaxis

PMID:8608232

ECO:0000314

P

Figure 1A shows that addition of the chemokine rhIP-10 regulates the movement of the T-cells in vitro.

complete
CACAO 5482

public

GO:0090026

positive regulation of monocyte chemotaxis

PMID:8608232

ECO:0000314

P

Figure 1B shows that the addition of the chemokine rhIP-10 leads to increased monocyte chemotaxis.

complete
CACAO 5483

public

GO:0010596

negative regulation of endothelial cell migration

PMID:16484616

ECO:0000314

P

Fig 2A shows a significant drop in the migration of the HMEC-1 cells in the presence of CXCL10.

complete

public

GO:0090026

positive regulation of monocyte chemotaxis

PMID:8608232[

ECO:0000314

P

Figure 1B shows increased monocyte chemotaxis in response to IP10

complete
CACAO 5660

public

GO:0010596

negative regulation of endothelial cell migration

PMID:16484616

ECO:0000314

P

Fig 2A shows a significant drop in the migration of the HMEC-1 cells in the presence of CXCL10.

complete

public

GO:0042118

endothelial cell activation

PMID:19470579

ECO:0000316

UniProtKB:P49682


P

Figures 3A and 3B show that IP-10 is causing the endothelial cells to dissociate. Figure 5 shows that when an anti-CXCR3 antibody is introduced, IP-10 does not lead to cell dissociation.

complete
CACAO 6057

protected

involved_in

GO:0042981

regulation of apoptotic process

PMID:22652417

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0042056

chemoattractant activity

PMID:11157474

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0016525

negative regulation of angiogenesis

PMID:7540647

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:1901509

regulation of endothelial tube morphogenesis

PMID:16484616

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0042118

endothelial cell activation

PMID:19470579

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P49682

P

Seeded From UniProt

complete

protected

involved_in

GO:0090026

positive regulation of monocyte chemotaxis

PMID:8608232

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0010819

regulation of T cell chemotaxis

PMID:8608232

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0070098

chemokine-mediated signaling pathway

PMID:18645041

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0010818

T cell chemotaxis

PMID:18645041

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0008201

heparin binding

PMID:18645041

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

protected

part_of

GO:0005576

extracellular region

PMID:20041150

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0051281

positive regulation of release of sequestered calcium ion into cytosol

PMID:12782716

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0048248

CXCR3 chemokine receptor binding

PMID:12782716

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0042127

regulation of cell population proliferation

PMID:12782716

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:12782716

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0008009

chemokine activity

PMID:12782716

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

PMID:12782716

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0006935

chemotaxis

PMID:12782716

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0071222

cellular response to lipopolysaccharide

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000021269
RGD:621812
RGD:70069
RGD:708540
UniProtKB:P02778
UniProtKB:P10145
UniProtKB:P80162
UniProtKB:P80221

P

Seeded From UniProt

complete

protected

involved_in

GO:0070098

chemokine-mediated signaling pathway

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000021269
UniProtKB:O14625
UniProtKB:P02778

P

Seeded From UniProt

complete

protected

involved_in

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1888711
PANTHER:PTN000021269
UniProtKB:P02776
UniProtKB:P80162
UniProtKB:P80221

P

Seeded From UniProt

complete

protected

involved_in

GO:0030595

leukocyte chemotaxis

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000021269
RGD:70069
UniProtKB:P02776

P

Seeded From UniProt

complete

protected

involved_in

GO:0030593

neutrophil chemotaxis

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1339941
MGI:MGI:3037818
PANTHER:PTN000021269
RGD:619869
RGD:621812
RGD:70069
UniProtKB:P10145
UniProtKB:P79255
UniProtKB:P80162
UniProtKB:P80221

P

Seeded From UniProt

complete

protected

enables

GO:0008009

chemokine activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1339941
MGI:MGI:1888499
MGI:MGI:1888712
MGI:MGI:3037818
PANTHER:PTN000021269
RGD:619869
RGD:620209
RGD:621812
RGD:70069
RGD:708540
RGD:727827
UniProtKB:O14625
UniProtKB:O43927
UniProtKB:P02778
UniProtKB:P10145
UniProtKB:P80162
UniProtKB:P80221
UniProtKB:Q07325

F

Seeded From UniProt

complete

protected

involved_in

GO:0006955

immune response

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000021269
RGD:3305
RGD:620209
RGD:727827

P

Seeded From UniProt

complete

protected

involved_in

GO:0006954

inflammatory response

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1339941
PANTHER:PTN000021269
RGD:621812
RGD:708540

P

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:108068
MGI:MGI:1340094
MGI:MGI:1352449
MGI:MGI:1352450
MGI:MGI:1888499
PANTHER:PTN000021269
RGD:619869
RGD:620209
RGD:621812
RGD:70069
RGD:708540
UniProtKB:P19876

C

Seeded From UniProt

complete

protected

involved_in

GO:2000406

positive regulation of T cell migration

PMID:23620790

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0071222

cellular response to lipopolysaccharide

PMID:23776175

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

protected

involved_in

GO:0045859

regulation of protein kinase activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008603

P

Seeded From UniProt

complete

protected

involved_in

GO:0050918

positive chemotaxis

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0042056

P

Seeded From UniProt

complete

protected

involved_in

GO:1901740

negative regulation of myoblast fusion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17515
ensembl:ENSMUSP00000047646

P

Seeded From UniProt

complete

protected

involved_in

GO:0051607

defense response to virus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17515
ensembl:ENSMUSP00000047646

P

Seeded From UniProt

complete

protected

involved_in

GO:0045662

negative regulation of myoblast differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17515
ensembl:ENSMUSP00000047646

P

Seeded From UniProt

complete

protected

part_of

GO:0009897

external side of plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17515
ensembl:ENSMUSP00000047646

C

Seeded From UniProt

complete

protected

involved_in

GO:0009617

response to bacterium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17515
ensembl:ENSMUSP00000047646

P

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17515
ensembl:ENSMUSP00000047646

C

Seeded From UniProt

complete

protected

involved_in

GO:0034605

cellular response to heat

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48973
ensembl:ENSRNOP00000003649

P

Seeded From UniProt

complete

protected

involved_in

GO:0033280

response to vitamin D

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48973
ensembl:ENSRNOP00000003649

P

Seeded From UniProt

complete

protected

involved_in

GO:0032496

response to lipopolysaccharide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48973
ensembl:ENSRNOP00000003649

P

Seeded From UniProt

complete

protected

involved_in

GO:0030335

positive regulation of cell migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48973
ensembl:ENSRNOP00000003649

P

Seeded From UniProt

complete

protected

involved_in

GO:0016525

negative regulation of angiogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48973
ensembl:ENSRNOP00000003649

P

Seeded From UniProt

complete

protected

involved_in

GO:0010996

response to auditory stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48973
ensembl:ENSRNOP00000003649

P

Seeded From UniProt

complete

protected

involved_in

GO:0010332

response to gamma radiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48973
ensembl:ENSRNOP00000003649

P

Seeded From UniProt

complete

protected

involved_in

GO:0009615

response to virus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48973
ensembl:ENSRNOP00000003649

P

Seeded From UniProt

complete

protected

involved_in

GO:0009409

response to cold

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48973
ensembl:ENSRNOP00000003649

P

Seeded From UniProt

complete

protected

involved_in

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48973
ensembl:ENSRNOP00000003649

P

Seeded From UniProt

complete

protected

enables

GO:0008009

chemokine activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48973
ensembl:ENSRNOP00000003649

F

Seeded From UniProt

complete

protected

involved_in

GO:0006955

immune response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48973
ensembl:ENSRNOP00000003649

P

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48973
ensembl:ENSRNOP00000003649

C

Seeded From UniProt

complete

protected

involved_in

GO:0002690

positive regulation of leukocyte chemotaxis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48973
ensembl:ENSRNOP00000003649

P

Seeded From UniProt

complete

protected

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001089
InterPro:IPR001811
InterPro:IPR018048
InterPro:IPR036048

C

Seeded From UniProt

complete

protected

involved_in

GO:0006935

chemotaxis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033899

P

Seeded From UniProt

complete

protected

involved_in

GO:0006952

defense response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033899

P

Seeded From UniProt

complete

protected

involved_in

GO:0006955

immune response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001089
InterPro:IPR001811
InterPro:IPR018048
InterPro:IPR036048

P

Seeded From UniProt

complete

protected

enables

GO:0008009

chemokine activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001089
InterPro:IPR001811
InterPro:IPR018048
InterPro:IPR033899
InterPro:IPR036048

F

Seeded From UniProt

complete

protected

involved_in

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

PMID:12949249

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0031640

killing of cells of other organism

PMID:12949249

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0031640

killing of cells of other organism

PMID:12949249

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0008603

cAMP-dependent protein kinase regulator activity

PMID:10903763

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0008284

positive regulation of cell population proliferation

PMID:8798675

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0008015

blood circulation

PMID:8798675

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0008009

chemokine activity

PMID:10903763

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0007517

muscle organ development

PMID:8798675

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007267

cell-cell signaling

PMID:3925348

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007166

cell surface receptor signaling pathway

PMID:10903763

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007165

signal transduction

PMID:10201891

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0006954

inflammatory response

PMID:10903763

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0006935

chemotaxis

PMID:10903763

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0005102

signaling receptor binding

PMID:10201891

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:12782716

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0019221

cytokine-mediated signaling pathway

Reactome:R-HSA-6783783

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

Reactome:R-HSA-388396

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005576

extracellular region

Reactome:R-HSA-749456
Reactome:R-HSA-749454
Reactome:R-HSA-6784160
Reactome:R-HSA-380073
Reactome:R-HSA-374248

ECO:0000304

author statement supported by traceable reference used in manual assertion





C

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0202

C

Seeded From UniProt

complete

protected

involved_in

GO:0006954

inflammatory response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0395

P

Seeded From UniProt

complete

protected

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

protected

involved_in

GO:0006935

chemotaxis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0145

P

Seeded From UniProt

complete

protected

enables

GO:0005125

cytokine activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0202

F

Seeded From UniProt

complete




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