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HUMAN:ARBK1

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0046718

viral entry into host cell

PMID:23029581

ECO:0000315

P

Figure 5 says "GRK2 plays a role in YFV-17D entry"

complete
CACAO 5261

public

GO:0019079

viral genome replication

PMID:23029581

ECO:0000315

P

Figure 6 says "GRK2 plays a role in viral RNA synthesis."

complete
CACAO 5262

protected

involved_in

GO:0019079

viral genome replication

PMID:23029581

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0046718

viral entry into host cell

PMID:23029581

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

PMID:19946888

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0060048

cardiac muscle contraction

PMID:15051637

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045988

negative regulation of striated muscle contraction

PMID:15051637

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0033605

positive regulation of catecholamine secretion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P26817

P

Seeded From UniProt

complete

protected

enables

GO:0031694

alpha-2A adrenergic receptor binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21146

F

Seeded From UniProt

complete

protected

involved_in

GO:0018105

peptidyl-serine phosphorylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21146

P

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21146

C

Seeded From UniProt

complete

protected

involved_in

GO:0007217

tachykinin receptor signaling pathway

PMID:17986524

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007213

G protein-coupled acetylcholine receptor signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21146

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:17986524

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0004703

G protein-coupled receptor kinase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21146

F

Seeded From UniProt

complete

protected

enables

GO:0004672

protein kinase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21146

F

Seeded From UniProt

complete

protected

involved_in

GO:0003108

negative regulation of the force of heart contraction by chemical signal

PMID:15051637

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0002029

desensitization of G protein-coupled receptor signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21146

P

Seeded From UniProt

complete

protected

enables

GO:0031755

Edg-2 lysophosphatidic acid receptor binding

PMID:19306925

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0031623

receptor internalization

PMID:20074556

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0018107

peptidyl-threonine phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99MK8
ensembl:ENSMUSP00000086114

P

Seeded From UniProt

complete

protected

involved_in

GO:0018105

peptidyl-serine phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99MK8
ensembl:ENSMUSP00000086114

P

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99MK8
ensembl:ENSMUSP00000086114

C

Seeded From UniProt

complete

protected

involved_in

GO:0007507

heart development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99MK8
ensembl:ENSMUSP00000086114

P

Seeded From UniProt

complete

protected

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99MK8
ensembl:ENSMUSP00000086114

P

Seeded From UniProt

complete

protected

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99MK8
ensembl:ENSMUSP00000086114

P

Seeded From UniProt

complete

protected

enables

GO:0004703

G protein-coupled receptor kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99MK8
ensembl:ENSMUSP00000086114

F

Seeded From UniProt

complete

protected

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99MK8
ensembl:ENSMUSP00000086114

F

Seeded From UniProt

complete

protected

enables

GO:0004672

protein kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99MK8
ensembl:ENSMUSP00000086114

F

Seeded From UniProt

complete

protected

involved_in

GO:0002029

desensitization of G protein-coupled receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99MK8
ensembl:ENSMUSP00000086114

P

Seeded From UniProt

complete

protected

involved_in

GO:0002026

regulation of the force of heart contraction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99MK8
ensembl:ENSMUSP00000086114

P

Seeded From UniProt

complete

protected

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

F

Seeded From UniProt

complete

protected

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000961

F

Seeded From UniProt

complete

protected

enables

GO:0004703

G protein-coupled receptor kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000239

F

Seeded From UniProt

complete

protected

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000239
InterPro:IPR000719
InterPro:IPR000961
InterPro:IPR017441

F

Seeded From UniProt

complete

protected

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000239
InterPro:IPR000719
InterPro:IPR000961
InterPro:IPR008271

P

Seeded From UniProt

complete

protected

involved_in

GO:0007165

signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000239

P

Seeded From UniProt

complete

protected

enables

GO:0047696

beta-adrenergic receptor kinase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.11.15

F

Seeded From UniProt

complete

protected

enables

GO:0047696

beta-adrenergic receptor kinase activity

Reactome:R-HSA-8851797

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

Reactome:R-HSA-388396

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005929

cilium

Reactome:R-HSA-5633040

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-8982645
Reactome:R-HSA-8982641
Reactome:R-HSA-8851797
Reactome:R-HSA-416516
Reactome:R-HSA-111970
Reactome:R-HSA-111966

ECO:0000304

author statement supported by traceable reference used in manual assertion






C

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

Reactome:R-HSA-8866268
Reactome:R-HSA-111970

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

protected

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

protected

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

protected

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

protected

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

protected

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

protected

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete



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