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RAT:PDX1

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0010468

regulation of gene expression

PMID:10802714

ECO:0000315

P

Fig 1 shows that the mice with the AdCMV-PDX-1 gene (in lanes 2-8), all show insulin production, whereas the control groups do not.

complete
CACAO 5211

protected

involved_in

GO:0010468

regulation of gene expression

PMID:10802714

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0051594

detection of glucose

PMID:21108535

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21108535

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0003309

type B pancreatic cell differentiation

PMID:21108535

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:1990841

promoter-specific chromatin binding

PMID:19380737

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0070542

response to fatty acid

PMID:17181874

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0060290

transdifferentiation

PMID:10952464

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0051384

response to glucocorticoid

PMID:15331541

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0048863

stem cell differentiation

PMID:18253862

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0048863

stem cell differentiation

PMID:19382247

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0046982

protein heterodimerization activity

PMID:8524276

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:10094480

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:18253862

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:17641871

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0044877

protein-containing complex binding

PMID:10094480

ECO:0000353

physical interaction evidence used in manual assertion

RGD:3258

F

Seeded From UniProt

complete

protected

enables

GO:0044877

protein-containing complex binding

PMID:15650027

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0044877

protein-containing complex binding

PMID:11756538

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0043565

sequence-specific DNA binding

PMID:10094480

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0043388

positive regulation of DNA binding

PMID:11181516

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0043279

response to alkaloid

PMID:15448089

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0043201

response to leucine

PMID:19438972

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0042593

glucose homeostasis

PMID:11158595

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0042493

response to drug

PMID:17991720

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0035094

response to nicotine

PMID:18687784

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0034097

response to cytokine

PMID:16948396

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0033993

response to lipid

PMID:17991758

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0033273

response to vitamin

PMID:11833042

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0032024

positive regulation of insulin secretion

PMID:18439098

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0031667

response to nutrient levels

PMID:17882398

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0031100

animal organ regeneration

PMID:17690043

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0031016

pancreas development

PMID:18778483

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0030154

cell differentiation

PMID:11309388

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0014070

response to organic cyclic compound

PMID:19438972

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0010942

positive regulation of cell death

PMID:10580420

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0010260

animal organ senescence

PMID:17467845

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0010157

response to chlorate

PMID:17221210

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0010040

response to iron(II) ion

PMID:16081762

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0009749

response to glucose

PMID:15148392

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0009749

response to glucose

PMID:18230696

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0009611

response to wounding

PMID:17583748

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0008284

positive regulation of cell population proliferation

PMID:11158595

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0008134

transcription factor binding

PMID:19264802

ECO:0000353

physical interaction evidence used in manual assertion

RGD:1557009

F

Seeded From UniProt

complete

protected

involved_in

GO:0007417

central nervous system development

PMID:10751390

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007224

smoothened signaling pathway

PMID:11181516

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0006366

transcription by RNA polymerase II

PMID:15151993

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0006351

transcription, DNA-templated

PMID:15151993

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:16887799

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

colocalizes_with

GO:0005737

cytoplasm

PMID:15609091

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:10094480

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0003700

DNA-binding transcription factor activity

PMID:15151993

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

protected

contributes_to

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:10094480

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000166
FB:FBgn0004053
MGI:MGI:102851
MGI:MGI:96174
PANTHER:PTN002518688
RGD:62387
UniProtKB:P14651
UniProtKB:P14652
UniProtKB:P31249

P

Seeded From UniProt

complete

protected

involved_in

GO:0031018

endocrine pancreas development

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:102851
PANTHER:PTN002903050
ZFIN:ZDB-GENE-990415-122

P

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0051481
MGI:MGI:102851
MGI:MGI:96174
PANTHER:PTN002518688
RGD:62387
UniProtKB:O43364
UniProtKB:P14652

C

Seeded From UniProt

complete

protected

enables

GO:0003700

DNA-binding transcription factor activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000166
MGI:MGI:102851
MGI:MGI:96175
PANTHER:PTN002518688
RGD:62387

F

Seeded From UniProt

complete

protected

involved_in

GO:0003309

type B pancreatic cell differentiation

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002903050
RGD:62387
UniProtKB:P52945

P

Seeded From UniProt

complete

protected

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:102851
MGI:MGI:96174
MGI:MGI:96184
PANTHER:PTN002518688
UniProtKB:P14651

F

Seeded From UniProt

complete

protected

involved_in

GO:0030073

insulin secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52945
ensembl:ENSP00000370421

P

Seeded From UniProt

complete

protected

involved_in

GO:0007263

nitric oxide mediated signal transduction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52945
ensembl:ENSP00000370421

P

Seeded From UniProt

complete

protected

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52945
ensembl:ENSP00000370421

C

Seeded From UniProt

complete

protected

involved_in

GO:0003309

type B pancreatic cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52945
ensembl:ENSP00000370421

P

Seeded From UniProt

complete

protected

involved_in

GO:2000675

negative regulation of type B pancreatic cell apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52946
ensembl:ENSMUSP00000082729

P

Seeded From UniProt

complete

protected

involved_in

GO:1902236

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52946
ensembl:ENSMUSP00000082729

P

Seeded From UniProt

complete

protected

involved_in

GO:0048565

digestive tract development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52946
ensembl:ENSMUSP00000082729

P

Seeded From UniProt

complete

protected

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52946
ensembl:ENSMUSP00000082729

P

Seeded From UniProt

complete

protected

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52946
ensembl:ENSMUSP00000082729

P

Seeded From UniProt

complete

protected

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52946
ensembl:ENSMUSP00000082729

F

Seeded From UniProt

complete

protected

involved_in

GO:0042593

glucose homeostasis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52946
ensembl:ENSMUSP00000082729

P

Seeded From UniProt

complete

protected

involved_in

GO:0042127

regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52946
ensembl:ENSMUSP00000082729

P

Seeded From UniProt

complete

protected

involved_in

GO:0035774

positive regulation of insulin secretion involved in cellular response to glucose stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52946
ensembl:ENSMUSP00000082729

P

Seeded From UniProt

complete

protected

involved_in

GO:0031018

endocrine pancreas development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52946
ensembl:ENSMUSP00000082729

P

Seeded From UniProt

complete

protected

involved_in

GO:0031017

exocrine pancreas development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52946
ensembl:ENSMUSP00000082729

P

Seeded From UniProt

complete

protected

involved_in

GO:0031016

pancreas development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52946
ensembl:ENSMUSP00000082729

P

Seeded From UniProt

complete

protected

involved_in

GO:0030154

cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52946
ensembl:ENSMUSP00000082729

P

Seeded From UniProt

complete

protected

part_of

GO:0016607

nuclear speck

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52946
ensembl:ENSMUSP00000082729

C

Seeded From UniProt

complete

protected

involved_in

GO:0016331

morphogenesis of embryonic epithelium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52946
ensembl:ENSMUSP00000082729

P

Seeded From UniProt

complete

protected

involved_in

GO:0008285

negative regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52946
ensembl:ENSMUSP00000082729

P

Seeded From UniProt

complete

protected

involved_in

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52946
ensembl:ENSMUSP00000082729

P

Seeded From UniProt

complete

protected

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52946
ensembl:ENSMUSP00000082729

P

Seeded From UniProt

complete

protected

involved_in

GO:0006006

glucose metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52946
ensembl:ENSMUSP00000082729

P

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52946
ensembl:ENSMUSP00000082729

C

Seeded From UniProt

complete

protected

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52946
ensembl:ENSMUSP00000082729

F

Seeded From UniProt

complete

protected

enables

GO:0003682

chromatin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52946
ensembl:ENSMUSP00000082729

F

Seeded From UniProt

complete

protected

enables

GO:0003677

DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52946
ensembl:ENSMUSP00000082729

F

Seeded From UniProt

complete

protected

involved_in

GO:0001889

liver development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52946
ensembl:ENSMUSP00000082729

P

Seeded From UniProt

complete

protected

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52946
ensembl:ENSMUSP00000082729

F

Seeded From UniProt

complete

protected

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52946
ensembl:ENSMUSP00000082729

P

Seeded From UniProt

complete

protected

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001356
InterPro:IPR009057
InterPro:IPR017995
InterPro:IPR020479

F

Seeded From UniProt

complete

protected

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017995

F

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017995

C

Seeded From UniProt

complete

protected

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017970
InterPro:IPR017995

P

Seeded From UniProt

complete

protected

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017970

F

Seeded From UniProt

complete

protected

involved_in

GO:0006355

regulation of transcription, DNA-templated

PMID:11687580

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0003700

DNA-binding transcription factor activity

PMID:11978636

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0003677

DNA binding

GO_REF:0000037
GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238
UniProtKB-KW:KW-0371

F

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0091

C

Seeded From UniProt

complete




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