GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com


Jump to: navigation, search


You don't have sufficient rights on this wiki to edit tables. Perhaps you need to log in. Changes you make in the Table editor will not be saved back to the wiki

See Help for Help on this wiki. See the documentation for how to use the table editor


Meyerson, M, Enders, GH, Wu, CL, Su, LK, Gorka, C, Nelson, C, Harlow, E and Tsai, LH (1992) A family of human cdc2-related protein kinases. EMBO J. 11:2909-17


The p34cdc2 protein kinase is known to regulate important transitions in the eukaryotic cell cycle. We have identified 10 human protein kinases based on their structural relation to p34cdc2. Seven of these kinases are novel and the products of five share greater than 50% amino acid sequence identity with p34cdc2. The seven novel genes are broadly expressed in human cell lines and tissues with each displaying some cell type or tissue specificity. The cdk3 gene, like cdc2 and cdk2, can complement cdc28 mutants of Saccharomyces cerevisiae, suggesting that all three of these protein kinases can play roles in the regulation of the mammalian cell cycle. The identification of a large family of cdc2-related kinases opens the possibility of combinatorial regulation of the cell cycle together with the emerging large family of cyclins.


PubMed PMC556772


Amino Acid Sequence; CDC2 Protein Kinase/genetics; Cell Cycle; Cell Line; Cloning, Molecular; DNA, Neoplasm/genetics; DNA, Neoplasm/isolation & purification; Genetic Complementation Test; HeLa Cells; Humans; Molecular Sequence Data; Multigene Family; RNA, Neoplasm/genetics; RNA, Neoplasm/isolation & purification; Saccharomyces cerevisiae/enzymology; Saccharomyces cerevisiae/genetics; Sequence Homology, Nucleic Acid