GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com


Jump to: navigation, search


You don't have sufficient rights on this wiki to edit tables. Perhaps you need to log in. Changes you make in the Table editor will not be saved back to the wiki

See Help for Help on this wiki. See the documentation for how to use the table editor


Barron, MJ, Brookes, SJ, Draper, CE, Garrod, D, Kirkham, J, Shore, RC and Dixon, MJ (2008) The cell adhesion molecule nectin-1 is critical for normal enamel formation in mice. Hum. Mol. Genet. 17:3509-20


Nectin-1 is a member of a sub-family of immunoglobulin-like adhesion molecules and a component of adherens junctions. In the current study, we have shown that mice lacking nectin-1 exhibit defective enamel formation in their incisor teeth. Although the incisors of nectin-1-null mice were hypomineralized, the protein composition of the enamel matrix was unaltered. While strong immunostaining for nectin-1 was observed at the interface between the maturation-stage ameloblasts and the underlying cells of the stratum intermedium (SI), its absence in nectin-1-null mice correlated with separation of the cell layers at this interface. Numerous, large desmosomes were present at this interface in wild-type mice; however, where adhesion persisted in the mutant mice, the desmosomes were smaller and less numerous. Nectins have been shown to regulate tight junction formation; however, this is the first report showing that they may also participate in the regulation of desmosome assembly. Importantly, our results show that integrity of the SI-ameloblast interface is essential for normal enamel mineralization.


PubMed PMC2572697 Online version:10.1093/hmg/ddn243


Adherens Junctions/metabolism; Ameloblasts/cytology; Ameloblasts/physiology; Amelogenesis; Animals; Apoptosis; Cell Adhesion; Cell Adhesion Molecules/genetics; Cell Adhesion Molecules/metabolism; Cell Proliferation; Dental Enamel/chemistry; Dental Enamel/metabolism; Dental Enamel Proteins/analysis; Desmoplakins/analysis; Desmosomes/metabolism; Desmosomes/ultrastructure; Enamel Organ/chemistry; Enamel Organ/cytology; Enamel Organ/metabolism; Ferric Compounds/metabolism; Immunohistochemistry; Incisor/abnormalities; Incisor/radiography; Mice; Mice, Transgenic; Microphthalmos; Microscopy, Electron, Transmission; Tight Junctions/metabolism; Tight Junctions/ultrastructure