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PMID:18703497
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| Citation |
Barron, MJ, Brookes, SJ, Draper, CE, Garrod, D, Kirkham, J, Shore, RC and Dixon, MJ (2008) The cell adhesion molecule nectin-1 is critical for normal enamel formation in mice. Hum. Mol. Genet. 17:3509-20 |
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| Abstract |
Nectin-1 is a member of a sub-family of immunoglobulin-like adhesion molecules and a component of adherens junctions. In the current study, we have shown that mice lacking nectin-1 exhibit defective enamel formation in their incisor teeth. Although the incisors of nectin-1-null mice were hypomineralized, the protein composition of the enamel matrix was unaltered. While strong immunostaining for nectin-1 was observed at the interface between the maturation-stage ameloblasts and the underlying cells of the stratum intermedium (SI), its absence in nectin-1-null mice correlated with separation of the cell layers at this interface. Numerous, large desmosomes were present at this interface in wild-type mice; however, where adhesion persisted in the mutant mice, the desmosomes were smaller and less numerous. Nectins have been shown to regulate tight junction formation; however, this is the first report showing that they may also participate in the regulation of desmosome assembly. Importantly, our results show that integrity of the SI-ameloblast interface is essential for normal enamel mineralization. |
| Links |
PubMed PMC2572697 Online version:10.1093/hmg/ddn243 |
| Keywords |
Adherens Junctions/metabolism; Ameloblasts/cytology; Ameloblasts/physiology; Amelogenesis; Animals; Apoptosis; Cell Adhesion; Cell Adhesion Molecules/genetics; Cell Adhesion Molecules/metabolism; Cell Proliferation; Dental Enamel/chemistry; Dental Enamel/metabolism; Dental Enamel Proteins/analysis; Desmoplakins/analysis; Desmosomes/metabolism; Desmosomes/ultrastructure; Enamel Organ/chemistry; Enamel Organ/cytology; Enamel Organ/metabolism; Ferric Compounds/metabolism; Immunohistochemistry; Incisor/abnormalities; Incisor/radiography; Mice; Mice, Transgenic; Microphthalmos; Microscopy, Electron, Transmission; Tight Junctions/metabolism; Tight Junctions/ultrastructure |
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