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Wong, L, Weadick, CJ, Kuo, C, Chang, BS and Tropepe, V (2010) Duplicate dmbx1 genes regulate progenitor cell cycle and differentiation during zebrafish midbrain and retinal development. BMC Dev. Biol. 10:100
The Dmbx1 gene is important for the development of the midbrain and hindbrain, and mouse gene targeting experiments reveal that this gene is required for mediating postnatal and adult feeding behaviours. A single Dmbx1 gene exists in terrestrial vertebrate genomes, while teleost genomes have at least two paralogs. We compared the loss of function of the zebrafish dmbx1a and dmbx1b genes in order to gain insight into the molecular mechanism by which dmbx1 regulates neurogenesis, and to begin to understand why these duplicate genes have been retained in the zebrafish genome.
Animals; Animals, Genetically Modified; Cell Cycle/physiology; Cell Differentiation/physiology; Embryo, Nonmammalian/anatomy & histology; Embryo, Nonmammalian/pathology; Embryo, Nonmammalian/physiology; Evolution, Molecular; Gene Expression Regulation, Developmental; Gene Knockdown Techniques; Mesencephalon/embryology; Mesencephalon/growth & development; Mesencephalon/pathology; Mice; Neurogenesis/physiology; Oligonucleotides, Antisense/genetics; Oligonucleotides, Antisense/metabolism; Otx Transcription Factors/genetics; Otx Transcription Factors/metabolism; Protein Isoforms/genetics; Protein Isoforms/metabolism; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/metabolism; Retina/embryology; Retina/growth & development; Retina/pathology; Stem Cells/cytology; Stem Cells/physiology; Transcription Factors/genetics; Transcription Factors/metabolism; Zebrafish/anatomy & histology; Zebrafish/embryology; Zebrafish/growth & development; Zebrafish Proteins/genetics; Zebrafish Proteins/metabolism