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Latonen, L, Järvinen, PM, Suomela, S, Moore, HM, Saarialho-Kere, U and Laiho, M (2010) Ultraviolet B radiation regulates cysteine-rich protein 1 in human keratinocytes. Photodermatol Photoimmunol Photomed 26:70-7


Cysteine-rich protein 1 (CRP1) is a growth-inhibitory cytoskeletal protein that is induced by ultraviolet (UV) C radiation radiation in fibroblasts. Our aim was to investigate the effects of UV radiation on CRP1 in keratinocytes, the main cell type subjected to UV radiation in the human body.


PubMed Online version:10.1111/j.1600-0781.2010.00488.x


Adolescent; Adult; Aged; Aged, 80 and over; Apoptosis/radiation effects; Carcinoma, Squamous Cell/metabolism; Carcinoma, Squamous Cell/pathology; Caspases/metabolism; Cell Line, Tumor; Dose-Response Relationship, Radiation; Female; Humans; Keratinocytes/metabolism; Keratinocytes/pathology; Keratosis, Actinic/metabolism; Keratosis, Actinic/pathology; Male; Middle Aged; Nuclear Proteins/biosynthesis; Skin/metabolism; Skin/pathology; Skin Neoplasms/metabolism; Skin Neoplasms/pathology; Ultraviolet Rays/adverse effects