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RAT:BACE1

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

protected

part_of

GO:0009986

cell surface

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P56818

C

Seeded From UniProt

complete

protected

part_of

GO:0005769

early endosome

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P56818

C

Seeded From UniProt

complete

protected

enables

GO:0004190

aspartic-type endopeptidase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P56818

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0050435

amyloid-beta metabolic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P56818

P

Seeded From UniProt

complete

protected

enables

GO:0004175

endopeptidase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P56817

F

Seeded From UniProt

complete

protected

part_of

GO:0055037

recycling endosome

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P56818

C

Seeded From UniProt

complete

protected

part_of

GO:0055037

recycling endosome

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P56817

C

Seeded From UniProt

complete

protected

part_of

GO:0005770

late endosome

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P56817

C

Seeded From UniProt

complete

protected

part_of

GO:0005769

early endosome

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P56817

C

Seeded From UniProt

complete

protected

part_of

GO:0005764

lysosome

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P56817

C

Seeded From UniProt

complete

protected

part_of

GO:0009986

cell surface

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P56817

C

Seeded From UniProt

complete

protected

part_of

GO:0005802

trans-Golgi network

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P56817

C

Seeded From UniProt

complete

protected

part_of

GO:0005802

trans-Golgi network

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P56818

C

Seeded From UniProt

complete

protected

involved_in

GO:0050435

amyloid-beta metabolic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P56817

P

Seeded From UniProt

complete

protected

involved_in

GO:0006508

proteolysis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P56817

P

Seeded From UniProt

complete

protected

part_of

GO:0005794

Golgi apparatus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P56817

C

Seeded From UniProt

complete

protected

part_of

GO:0005768

endosome

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P56817

C

Seeded From UniProt

complete

protected

enables

GO:0004190

aspartic-type endopeptidase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P56817

F

Seeded From UniProt

complete

protected

involved_in

GO:1904646

cellular response to amyloid-beta

PMID:26984601

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0071287

cellular response to manganese ion

PMID:18583042

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0071280

cellular response to copper ion

PMID:18583042

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0060134

prepulse inhibition

PMID:28281673

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0050966

detection of mechanical stimulus involved in sensory perception of pain

PMID:28012171

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0050435

amyloid-beta metabolic process

PMID:10531052

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0043025

neuronal cell body

PMID:26552445

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0030425

dendrite

PMID:26552445

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0030424

axon

PMID:26552445

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0010288

response to lead ion

PMID:29908845

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0009314

response to radiation

PMID:26972535

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0008233

peptidase activity

PMID:10531052

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

part_of

GO:0008021

synaptic vesicle

PMID:26296617

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005794

Golgi apparatus

PMID:10531052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005768

endosome

PMID:10531052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0050435

amyloid-beta metabolic process

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002299446
RGD:2191
UniProtKB:P56817

P

Seeded From UniProt

complete

protected

involved_in

GO:0030163

protein catabolic process

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000201569
PANTHER:PTN000342793
UniProtKB:P0CY27
UniProtKB:Q5A8N2
UniProtKB:Q5AC08

P

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1346542
MGI:MGI:1860440
PANTHER:PTN002299446
UniProtKB:P56817
UniProtKB:Q9Y5Z0

C

Seeded From UniProt

complete

protected

involved_in

GO:0006509

membrane protein ectodomain proteolysis

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002299446
UniProtKB:P56817
UniProtKB:Q9Y5Z0

P

Seeded From UniProt

complete

protected

involved_in

GO:0006508

proteolysis

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000190503
CGD:CAL0000194661
CGD:CAL0000196689
CGD:CAL0000201140
MGI:MGI:1346542
PANTHER:PTN000342793
RGD:621511
SGD:S000002551
TAIR:locus:2008940
UniProtKB:P00797
UniProtKB:P0CY27
UniProtKB:P41748
UniProtKB:P43094
UniProtKB:P56817
UniProtKB:Q59VH7
UniProtKB:Q5AC08
UniProtKB:Q8I6Z5
WB:WBGene00000217

P

Seeded From UniProt

complete

protected

part_of

GO:0005802

trans-Golgi network

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1346542
PANTHER:PTN002299446
UniProtKB:P56817

C

Seeded From UniProt

complete

protected

part_of

GO:0005794

Golgi apparatus

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1346542
PANTHER:PTN002299446
RGD:2191
UniProtKB:P56817
UniProtKB:Q9Y5Z0

C

Seeded From UniProt

complete

protected

part_of

GO:0005768

endosome

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1346542
PANTHER:PTN002299446
RGD:2191
UniProtKB:P56817

C

Seeded From UniProt

complete

protected

enables

GO:0004190

aspartic-type endopeptidase activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000196689
MGI:MGI:107361
MGI:MGI:1915935
MGI:MGI:88562
PANTHER:PTN000342793
PomBase:SPCC1795.09
RGD:2446
SGD:S000001277
SGD:S000002551
SGD:S000004110
SGD:S000004111
TAIR:locus:2145954
UniProtKB:P00797
UniProtKB:P0CY27
UniProtKB:P14091
UniProtKB:P20142
UniProtKB:P56817
UniProtKB:Q4WNV0
UniProtKB:Q5AC08
UniProtKB:Q8I6Z5
UniProtKB:Q9LTW4
UniProtKB:Q9Y5Z0

F

Seeded From UniProt

complete

protected

enables

GO:0001540

amyloid-beta binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000343246
UniProtKB:P56817

F

Seeded From UniProt

complete

protected

involved_in

GO:2000300

regulation of synaptic vesicle exocytosis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56818
ensembl:ENSMUSP00000034591

P

Seeded From UniProt

complete

protected

part_of

GO:0098793

presynapse

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56818
ensembl:ENSMUSP00000034591

C

Seeded From UniProt

complete

protected

part_of

GO:0098686

hippocampal mossy fiber to CA3 synapse

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56818
ensembl:ENSMUSP00000034591

C

Seeded From UniProt

complete

protected

part_of

GO:0055037

recycling endosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56818
ensembl:ENSMUSP00000034591

C

Seeded From UniProt

complete

protected

involved_in

GO:0050804

modulation of chemical synaptic transmission

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56818
ensembl:ENSMUSP00000034591

P

Seeded From UniProt

complete

protected

involved_in

GO:0050435

amyloid-beta metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56818
ensembl:ENSMUSP00000034591

P

Seeded From UniProt

complete

protected

part_of

GO:0031410

cytoplasmic vesicle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56818
ensembl:ENSMUSP00000034591

C

Seeded From UniProt

complete

protected

part_of

GO:0030424

axon

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56818
ensembl:ENSMUSP00000034591

C

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56818
ensembl:ENSMUSP00000034591

C

Seeded From UniProt

complete

protected

part_of

GO:0009986

cell surface

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56818
ensembl:ENSMUSP00000034591

C

Seeded From UniProt

complete

protected

involved_in

GO:0006508

proteolysis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56818
ensembl:ENSMUSP00000034591

P

Seeded From UniProt

complete

protected

part_of

GO:0005802

trans-Golgi network

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56818
ensembl:ENSMUSP00000034591

C

Seeded From UniProt

complete

protected

part_of

GO:0005769

early endosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56818
ensembl:ENSMUSP00000034591

C

Seeded From UniProt

complete

protected

part_of

GO:0005768

endosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56818
ensembl:ENSMUSP00000034591

C

Seeded From UniProt

complete

protected

enables

GO:0004190

aspartic-type endopeptidase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56818
ensembl:ENSMUSP00000034591

F

Seeded From UniProt

complete

protected

enables

GO:0004175

endopeptidase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56818
ensembl:ENSMUSP00000034591

F

Seeded From UniProt

complete

protected

part_of

GO:0055037

recycling endosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56817
ensembl:ENSP00000318585

C

Seeded From UniProt

complete

protected

involved_in

GO:0050435

amyloid-beta metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56817
ensembl:ENSP00000318585

P

Seeded From UniProt

complete

protected

involved_in

GO:0043525

positive regulation of neuron apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56817
ensembl:ENSP00000318585

P

Seeded From UniProt

complete

protected

enables

GO:0019899

enzyme binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56817
ensembl:ENSP00000318585

F

Seeded From UniProt

complete

protected

part_of

GO:0009986

cell surface

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56817
ensembl:ENSP00000318585

C

Seeded From UniProt

complete

protected

enables

GO:0008233

peptidase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56817
ensembl:ENSP00000318585

F

Seeded From UniProt

complete

protected

involved_in

GO:0006509

membrane protein ectodomain proteolysis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56817
ensembl:ENSP00000318585

P

Seeded From UniProt

complete

protected

involved_in

GO:0006508

proteolysis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56817
ensembl:ENSP00000318585

P

Seeded From UniProt

complete

protected

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56817
ensembl:ENSP00000318585

C

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56817
ensembl:ENSP00000318585

C

Seeded From UniProt

complete

protected

part_of

GO:0005802

trans-Golgi network

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56817
ensembl:ENSP00000318585

C

Seeded From UniProt

complete

protected

part_of

GO:0005794

Golgi apparatus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56817
ensembl:ENSP00000318585

C

Seeded From UniProt

complete

protected

part_of

GO:0005771

multivesicular body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56817
ensembl:ENSP00000318585

C

Seeded From UniProt

complete

protected

part_of

GO:0005770

late endosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56817
ensembl:ENSP00000318585

C

Seeded From UniProt

complete

protected

part_of

GO:0005769

early endosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56817
ensembl:ENSP00000318585

C

Seeded From UniProt

complete

protected

part_of

GO:0005768

endosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56817
ensembl:ENSP00000318585

C

Seeded From UniProt

complete

protected

part_of

GO:0005764

lysosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56817
ensembl:ENSP00000318585

C

Seeded From UniProt

complete

protected

enables

GO:0004190

aspartic-type endopeptidase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56817
ensembl:ENSP00000318585

F

Seeded From UniProt

complete

protected

enables

GO:0004175

endopeptidase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56817
ensembl:ENSP00000318585

F

Seeded From UniProt

complete

protected

enables

GO:0001540

amyloid-beta binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56817
ensembl:ENSP00000318585

F

Seeded From UniProt

complete

protected

enables

GO:0004190

aspartic-type endopeptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001461
InterPro:IPR001969
InterPro:IPR009119
InterPro:IPR009120

F

Seeded From UniProt

complete

protected

involved_in

GO:0006508

proteolysis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001461
InterPro:IPR001969
InterPro:IPR009119
InterPro:IPR009120

P

Seeded From UniProt

complete

protected

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR009119
InterPro:IPR009120

C

Seeded From UniProt

complete

protected

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

protected

part_of

GO:0031410

cytoplasmic vesicle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0968

C

Seeded From UniProt

complete

protected

part_of

GO:0005764

lysosome

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0458
UniProtKB-SubCell:SL-0158

C

Seeded From UniProt

complete

protected

part_of

GO:0005794

Golgi apparatus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0333
UniProtKB-SubCell:SL-0132

C

Seeded From UniProt

complete

protected

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0256
UniProtKB-SubCell:SL-0095

C

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

protected

part_of

GO:0005768

endosome

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0967
UniProtKB-SubCell:SL-0101

C

Seeded From UniProt

complete

protected

enables

GO:0004190

aspartic-type endopeptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0064

F

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

protected

involved_in

GO:0006508

proteolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

protected

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

protected

enables

GO:0008233

peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

protected

part_of

GO:0005770

late endosome

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0152

C

Seeded From UniProt

complete

protected

part_of

GO:0030659

cytoplasmic vesicle membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0089

C

Seeded From UniProt

complete

protected

part_of

GO:0045121

membrane raft

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0370

C

Seeded From UniProt

complete

protected

part_of

GO:0055037

recycling endosome

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0232

C

Seeded From UniProt

complete

protected

part_of

GO:0005769

early endosome

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0094

C

Seeded From UniProt

complete

protected

part_of

GO:0009986

cell surface

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0310

C

Seeded From UniProt

complete




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