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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0004842

ubiquitin-protein ligase activity

PMID:17456438

ECO:0000314

F

Figure 2

complete
CACAO 3712

public

GO:0044743

intracellular protein transmembrane import

PMID:20194754

ECO:0000316

UniProtKB:Q0KHV6


P

Figure 2 shows PINK1 is required for Parkin translocation

complete
CACAO 10621

public

GO:0031398

positive regulation of protein ubiquitination

PMID:20194754

ECO:0000314

P

Figure 4 shows parkin overexpression can cause mfn ubiquitination in the absense of PINK1

complete
CACAO 10622

public

GO:0090141

positive regulation of mitochondrial fission

PMID:20194754

ECO:0000316

UniProtKB:Q0KHV6


P

Figure 1 shows Parkin and PINK1 activity promotes mitochondrial fission

complete
CACAO 10623

public

GO:0010637

negative regulation of mitochondrial fusion

PMID:20194754

ECO:0000316

UniProtKB:Q0KHV6


P

Figure 1 shows Parkin and PINK1 activity inhibits mitochondrial fusion

complete
CACAO 10624

protected

involved_in

GO:1904457

positive regulation of neuronal action potential

PMID:28435104

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:1904061

positive regulation of locomotor rhythm

PMID:28435104

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0004842

ubiquitin-protein transferase activity

PMID:17456438

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0048078

positive regulation of compound eye pigmentation

PMID:19692353

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:1900407

regulation of cellular response to oxidative stress

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0041100
PANTHER:PTN000188399
UniProtKB:O60260

P

Seeded From UniProt

complete

protected

enables

GO:0061630

ubiquitin protein ligase activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0017418
FB:FBgn0041100
MGI:MGI:1355296
PANTHER:PTN000188395
TAIR:locus:2057401
UniProtKB:O60260
UniProtKB:P50876

F

Seeded From UniProt

complete

protected

involved_in

GO:0042981

regulation of apoptotic process

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000188399
ZFIN:ZDB-GENE-050417-109

P

Seeded From UniProt

complete

protected

involved_in

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1355296
PANTHER:PTN000188395

P

Seeded From UniProt

complete

protected

enables

GO:0031624

ubiquitin conjugating enzyme binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0017418
FB:FBgn0041100
PANTHER:PTN000188395
UniProtKB:O60260
UniProtKB:O95376
UniProtKB:Q9Y4X5
WB:WBGene00003967

F

Seeded From UniProt

complete

protected

involved_in

GO:0010821

regulation of mitochondrion organization

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0041100
PANTHER:PTN000188399
UniProtKB:O60260

P

Seeded From UniProt

complete

protected

involved_in

GO:0006511

ubiquitin-dependent protein catabolic process

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0017418
FB:FBgn0041100
MGI:MGI:1344361
MGI:MGI:1344363
PANTHER:PTN000188395
UniProtKB:O60260
UniProtKB:O95376
UniProtKB:Q7Z419

P

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000188399
RGD:61797
UniProtKB:O60260

C

Seeded From UniProt

complete

protected

part_of

GO:0005794

Golgi apparatus

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000188399
UniProtKB:O60260

C

Seeded From UniProt

complete

protected

part_of

GO:0005783

endoplasmic reticulum

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000188399
RGD:61797
UniProtKB:O60260

C

Seeded From UniProt

complete

protected

part_of

GO:0005739

mitochondrion

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0041100
MGI:MGI:1355296
PANTHER:PTN000188399
RGD:61797
UniProtKB:O60260

C

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0017418
FB:FBgn0041100
MGI:MGI:1355296
PANTHER:PTN000188395
RGD:61797
UniProtKB:O60260
UniProtKB:O95376
UniProtKB:Q7Z419
UniProtKB:Q9UBS8
UniProtKB:Q9Y4X5
WB:WBGene00003967
WB:WBGene00016158

C

Seeded From UniProt

complete

protected

involved_in

GO:0001933

negative regulation of protein phosphorylation

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000188399
UniProtKB:O60260

P

Seeded From UniProt

complete

protected

involved_in

GO:0000422

autophagy of mitochondrion

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0041100
PANTHER:PTN000188399
RGD:61797
UniProtKB:O60260

P

Seeded From UniProt

complete

protected

involved_in

GO:0000209

protein polyubiquitination

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0041100
PANTHER:PTN000188395
UniProtKB:O60260
UniProtKB:O95376

P

Seeded From UniProt

complete

protected

part_of

GO:0000151

ubiquitin ligase complex

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000188395
UniProtKB:O60260
WB:WBGene00003967

C

Seeded From UniProt

complete

protected

involved_in

GO:0000266

mitochondrial fission

PMID:18230723

ECO:0000316

genetic interaction evidence used in manual assertion

FB:FBgn0261276

P

Seeded From UniProt

complete

protected

involved_in

GO:0070050

neuron cellular homeostasis

PMID:17687034

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007005

mitochondrion organization

PMID:17687034

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0008344

adult locomotory behavior

PMID:17687034

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0000209

protein polyubiquitination

PMID:17456438

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0016567

protein ubiquitination

PMID:17456438

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0061630

ubiquitin protein ligase activity

PMID:17456438

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0031624

ubiquitin conjugating enzyme binding

PMID:17456438

ECO:0000353

physical interaction evidence used in manual assertion

HGNC:12490

F

Seeded From UniProt

complete

protected

involved_in

GO:0051865

protein autoubiquitination

PMID:17456438

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007005

mitochondrion organization

PMID:17123504

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007283

spermatogenesis

PMID:17123504

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0006979

response to oxidative stress

PMID:15911761

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0046329

negative regulation of JNK cascade

PMID:16002472

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007005

mitochondrion organization

PMID:12642658

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007005

mitochondrion organization

PMID:24852371

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0008344

adult locomotory behavior

PMID:24852371

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0016567

protein ubiquitination

PMID:24898855

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0000422

autophagy of mitochondrion

PMID:24192653

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0055069

zinc ion homeostasis

PMID:20302514

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007283

spermatogenesis

PMID:21383066

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0006979

response to oxidative stress

PMID:21383066

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0048477

oogenesis

PMID:21383066

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:20869429

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0048477

oogenesis

PMID:20869429

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:1900407

regulation of cellular response to oxidative stress

PMID:20483372

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0046329

negative regulation of JNK cascade

PMID:20496123

ECO:0000316

genetic interaction evidence used in manual assertion

FB:FBgn0010303

P

Seeded From UniProt

complete

protected

involved_in

GO:0046329

negative regulation of JNK cascade

PMID:20496123

ECO:0000316

genetic interaction evidence used in manual assertion

FB:FBgn0000229

P

Seeded From UniProt

complete

protected

involved_in

GO:0006511

ubiquitin-dependent protein catabolic process

PMID:20194754

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

colocalizes_with

GO:0005739

mitochondrion

PMID:20194754

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0010637

negative regulation of mitochondrial fusion

PMID:20194754

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0090141

positive regulation of mitochondrial fission

PMID:20194754

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0000422

autophagy of mitochondrion

PMID:20194754

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:20194754

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0010821

regulation of mitochondrion organization

PMID:19546216

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005739

mitochondrion

PMID:18957282

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0030382

sperm mitochondrion organization

PMID:18799731

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007005

mitochondrion organization

PMID:18799731

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007005

mitochondrion organization

PMID:18443288

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0000266

mitochondrial fission

PMID:18230723

ECO:0000316

genetic interaction evidence used in manual assertion

FB:FBgn0026479

P

Seeded From UniProt

complete

protected

involved_in

GO:0007005

mitochondrion organization

PMID:18230723

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0000266

mitochondrial fission

PMID:18230723

ECO:0000316

genetic interaction evidence used in manual assertion

FB:FBgn0029870

P

Seeded From UniProt

complete

protected

involved_in

GO:0008345

larval locomotory behavior

PMID:27430166

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0006513

protein monoubiquitination

PMID:29689197

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0042803

protein homodimerization activity

PMID:29689197

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0007005

mitochondrion organization

PMID:29456190

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0004842

ubiquitin-protein transferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003977
InterPro:IPR031127

F

Seeded From UniProt

complete

protected

part_of

GO:0005739

mitochondrion

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003977

C

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003977

C

Seeded From UniProt

complete

protected

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR031127

P

Seeded From UniProt

complete

protected

enables

GO:0046872

metal ion binding

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

protected

enables

GO:0016740

transferase activity

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

protected

enables

GO:0004842

ubiquitin-protein transferase activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000141802

F

Seeded From UniProt

complete

protected

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000141802

P

Seeded From UniProt

complete

protected

part_of

GO:0000151

ubiquitin ligase complex

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000141802

C

Seeded From UniProt

complete

protected

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00143

P

Seeded From UniProt

complete




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