GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
You don't have sufficient rights on this wiki to edit tables. Perhaps you need to log in. Changes you make in the Table editor will not be saved back to the wiki
Bender, LB, Suh, J, Carroll, CR, Fong, Y, Fingerman, IM, Briggs, SD, Cao, R, Zhang, Y, Reinke, V and Strome, S (2006) MES-4: an autosome-associated histone methyltransferase that participates in silencing the X chromosomes in the C. elegans germ line. Development 133:3907-17
Germ cell development in C. elegans requires that the X chromosomes be globally silenced during mitosis and early meiosis. We previously found that the nuclear proteins MES-2, MES-3, MES-4 and MES-6 regulate the different chromatin states of autosomes versus X chromosomes and are required for germline viability. Strikingly, the SET-domain protein MES-4 is concentrated on autosomes and excluded from the X chromosomes. Here, we show that MES-4 has histone H3 methyltransferase (HMT) activity in vitro, and is required for histone H3K36 dimethylation in mitotic and early meiotic germline nuclei and early embryos. MES-4 appears unlinked to transcription elongation, thus distinguishing it from other known H3K36 HMTs. Based on microarray analysis, loss of MES-4 leads to derepression of X-linked genes in the germ line. We discuss how an autosomally associated HMT may participate in silencing genes on the X chromosome, in coordination with the direct silencing effects of the other MES proteins.
Animals; Caenorhabditis elegans/embryology; Caenorhabditis elegans/enzymology; Caenorhabditis elegans/genetics; Caenorhabditis elegans Proteins/analysis; Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans Proteins/metabolism; Embryo, Nonmammalian/enzymology; Embryonic Development/genetics; Female; Gene Expression Regulation, Developmental; Gene Silencing; Germ Cells/cytology; Germ Cells/metabolism; Histone-Lysine N-Methyltransferase/analysis; Histone-Lysine N-Methyltransferase/genetics; Histone-Lysine N-Methyltransferase/metabolism; Histones/metabolism; Male; Meiosis/genetics; Methylation; Mitosis/genetics; Nuclear Proteins/metabolism; Oligonucleotide Array Sequence Analysis; Protein Methyltransferases; Transcription, Genetic; X Chromosome/genetics; X Chromosome/metabolism