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de Lencastre, A, Pincus, Z, Zhou, K, Kato, M, Lee, SS and Slack, FJ (2010) MicroRNAs both promote and antagonize longevity in C. elegans. Curr. Biol. 20:2159-68


aging is under genetic control in C. elegans, but the mechanisms of life-span regulation are not completely known. MicroRNAs (miRNAs) regulate various aspects of development and metabolism, and one miRNA has been previously implicated in life span.


PubMed PMC3023310 Online version:10.1016/j.cub.2010.11.015


Aging/genetics; Animals; Base Sequence; Caenorhabditis elegans/genetics; Caenorhabditis elegans/physiology; Humans; Insulin-Like Growth Factor I/physiology; Longevity/genetics; Longevity/physiology; MicroRNAs/chemistry; MicroRNAs/genetics; MicroRNAs/metabolism; Molecular Sequence Data; Nucleic Acid Conformation; Sequence Alignment; Sequence Analysis, RNA; Signal Transduction/physiology; Stress, Physiological