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Kim, YB, Ryu, JK, Lee, HJ, Lim, IJ, Park, D, Lee, MC and Kim, SU (2010) Midkine, heparin-binding growth factor, blocks kainic acid-induced seizure and neuronal cell death in mouse hippocampus. BMC Neurosci 11:42


Midkine (MK), a member of the heparin-binding growth factor family, which includes MK and pleiotrophin, is known to possess neurotrophic and neuroprotective properties in the central nervous system. Previous studies have shown that MK is an effective neuroprotective agent in reducing retinal degeneration caused by excessive light and decreasing hippocampal neuronal death in ischemic gerbil brain. The present study was undertaken to investigate whether MK acts as an anticonvulsant in kainic acid (KA)-induced seizure in mouse and blocks KA-mediated neuronal cell death in hippocampus.


PubMed PMC2861065 Online version:10.1186/1471-2202-11-42


Animals; Anticonvulsants/pharmacology; Anticonvulsants/therapeutic use; Astrocytes/drug effects; Astrocytes/metabolism; Biological Markers/metabolism; Cell Death/drug effects; Cell Death/physiology; Cytokines/pharmacology; Cytokines/therapeutic use; Disease Models, Animal; Epilepsy/chemically induced; Epilepsy/drug therapy; Epilepsy/physiopathology; Epilepsy, Temporal Lobe/chemically induced; Epilepsy, Temporal Lobe/drug therapy; Epilepsy, Temporal Lobe/physiopathology; Glial Fibrillary Acidic Protein/metabolism; Glutamate Decarboxylase/metabolism; Hippocampus/drug effects; Hippocampus/pathology; Hippocampus/physiopathology; Injections, Intraventricular; Interneurons/drug effects; Interneurons/metabolism; Kainic Acid/antagonists & inhibitors; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration/drug therapy; Nerve Degeneration/physiopathology; Nerve Degeneration/prevention & control; Neuroprotective Agents/pharmacology; Neuroprotective Agents/therapeutic use; Neurotoxins/antagonists & inhibitors; Pyramidal Cells/drug effects; Pyramidal Cells/metabolism; gamma-Aminobutyric Acid/metabolism