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HUMAN:P2RX7

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0010628

positive regulation of gene expression

PMID:22898868

ECO:0000315

P

Figure 4-P2X7R expression causes overexpression of the key glycolytic enzymes G3PDH and PFK.

complete
CACAO 5234

public

GO:0045821

positive regulation of glycolysis

PMID:22898868

ECO:0000315

P

From figure 1 it shows that P2X7R expression stimulates cell metabolism

complete
CACAO 5347

protected

involved_in

GO:0002931

response to ischemia

PMID:12849743

ECO:0000303

author statement without traceable support used in manual assertion

P

occurs_in:(UBERON:0002421)

Seeded From UniProt

complete

protected

involved_in

GO:0046931

pore complex assembly

PMID:25651887

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_input:(UniProtKB:Q4KMQ2)

Seeded From UniProt

complete

protected

involved_in

GO:0045794

negative regulation of cell volume

PMID:25651887

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:1904172

positive regulation of bleb assembly

PMID:25651887

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0017121

plasma membrane phospholipid scrambling

PMID:25651887

ECO:0000314

direct assay evidence used in manual assertion

P

has_input:(CHEBI:18303)

Seeded From UniProt

complete

protected

involved_in

GO:0035590

purinergic nucleotide receptor signaling pathway

PMID:25651887

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0034767

positive regulation of ion transmembrane transport

PMID:25651887

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(UniProtKB:Q4KMQ2)

Seeded From UniProt

complete

protected

involved_in

GO:0045821

positive regulation of glycolytic process

PMID:22898868

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0010628

positive regulation of gene expression

PMID:22898868

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

PMID:12107182

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0032060

bleb assembly

PMID:12107182

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0097190

apoptotic signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q64663

P

Seeded From UniProt

complete

protected

involved_in

GO:0051899

membrane depolarization

PMID:9038151

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0051709

regulation of killing of cells of other organism

PMID:17785580

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0051495

positive regulation of cytoskeleton organization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q64663

P

Seeded From UniProt

complete

protected

involved_in

GO:0050718

positive regulation of interleukin-1 beta secretion

PMID:17036048

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0050718

positive regulation of interleukin-1 beta secretion

PMID:18089587

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0046931

pore complex assembly

PMID:9038151

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045919

positive regulation of cytolysis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q64663

P

Seeded From UniProt

complete

protected

involved_in

GO:0045779

negative regulation of bone resorption

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9Z1M0

P

Seeded From UniProt

complete

protected

involved_in

GO:0043409

negative regulation of MAPK cascade

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9Z1M0

P

Seeded From UniProt

complete

protected

enables

GO:0042803

protein homodimerization activity

PMID:17895406

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0033198

response to ATP

PMID:9038151

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0032060

bleb assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q64663

P

Seeded From UniProt

complete

protected

part_of

GO:0032059

bleb

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q64663

C

Seeded From UniProt

complete

protected

involved_in

GO:0030501

positive regulation of bone mineralization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9Z1M0

P

Seeded From UniProt

complete

protected

involved_in

GO:0019233

sensory perception of pain

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9Z1M0

P

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

PMID:17785580

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0010524

positive regulation of calcium ion transport into cytosol

PMID:9038151

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007166

cell surface receptor signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q64663

P

Seeded From UniProt

complete

protected

part_of

GO:0005887

integral component of plasma membrane

PMID:9038151

ECO:0000305

curator inference used in manual assertion

GO:0001614

C

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

PMID:17785580

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q64663

C

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q64663

C

Seeded From UniProt

complete

protected

enables

GO:0005524

ATP binding

PMID:9038151

ECO:0000305

curator inference used in manual assertion

GO:0001614

F

Seeded From UniProt

complete

protected

enables

GO:0005102

signaling receptor binding

PMID:17785580

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q64663

F

Seeded From UniProt

complete

protected

enables

GO:0004931

extracellularly ATP-gated cation channel activity

PMID:9038151

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0002028

regulation of sodium ion transport

PMID:17785580

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q64663

P

Seeded From UniProt

complete

protected

enables

GO:0001614

purinergic nucleotide receptor activity

PMID:9038151

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0001530

lipopolysaccharide binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9Z1M0

F

Seeded From UniProt

complete

protected

enables

GO:0035381

ATP-gated ion channel activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000012953
dictyBase:DDB_G0272004

F

Seeded From UniProt

complete

protected

involved_in

GO:0034220

ion transmembrane transport

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000012953
UniProtKB:Q99571

P

Seeded From UniProt

complete

protected

part_of

GO:0016021

integral component of membrane

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000012953
RGD:620251
ZFIN:ZDB-GENE-020806-2

C

Seeded From UniProt

complete

protected

involved_in

GO:0006812

cation transport

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1097160
MGI:MGI:1339957
PANTHER:PTN000012953
ZFIN:ZDB-GENE-000427-3
ZFIN:ZDB-GENE-020806-2
ZFIN:ZDB-GENE-030319-3
ZFIN:ZDB-GENE-030319-4
ZFIN:ZDB-GENE-030319-5
ZFIN:ZDB-GENE-030319-6
ZFIN:ZDB-GENE-030319-7

P

Seeded From UniProt

complete

protected

part_of

GO:0005639

integral component of nuclear inner membrane

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000804619
RGD:3241

C

Seeded From UniProt

complete

protected

enables

GO:0004931

extracellularly ATP-gated cation channel activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1097160
MGI:MGI:1338859
MGI:MGI:1339957
MGI:MGI:2137026
MGI:MGI:2665170
PANTHER:PTN000804619
RGD:3240
RGD:3241
RGD:3243
RGD:620251
RGD:620253
RGD:620256
RGD:62073
UniProtKB:Q99571
UniProtKB:Q99572
UniProtKB:Q9UBL9
ZFIN:ZDB-GENE-020806-2
ZFIN:ZDB-GENE-030319-2
ZFIN:ZDB-GENE-030319-3
ZFIN:ZDB-GENE-030319-6
ZFIN:ZDB-GENE-030319-7

F

Seeded From UniProt

complete

protected

enables

GO:0001614

purinergic nucleotide receptor activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1098235
PANTHER:PTN000012953
RGD:3241
RGD:62073
UniProtKB:P51575
UniProtKB:Q99571
UniProtKB:Q99572

F

Seeded From UniProt

complete

protected

involved_in

GO:0060079

excitatory postsynaptic potential

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004931

P

Seeded From UniProt

complete

protected

involved_in

GO:0060079

excitatory postsynaptic potential

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004931

P

Seeded From UniProt

complete

protected

involved_in

GO:0060079

excitatory postsynaptic potential

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004931

P

Seeded From UniProt

complete

protected

involved_in

GO:0060079

excitatory postsynaptic potential

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004931

P

Seeded From UniProt

complete

protected

part_of

GO:0098793

presynapse

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0016079

C

Seeded From UniProt

complete

protected

part_of

GO:0098794

postsynapse

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0060079

C

Seeded From UniProt

complete

protected

part_of

GO:0098794

postsynapse

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0060079

C

Seeded From UniProt

complete

protected

involved_in

GO:0050717

positive regulation of interleukin-1 alpha secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0050715

positive regulation of cytokine secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0050714

positive regulation of protein secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0048873

homeostasis of number of cells within a tissue

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0048705

skeletal system morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0046931

pore complex assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0046513

ceramide biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0045794

negative regulation of cell volume

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0045779

negative regulation of bone resorption

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0045778

positive regulation of ossification

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0045332

phospholipid translocation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

part_of

GO:0045202

synapse

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

C

Seeded From UniProt

complete

protected

involved_in

GO:0043410

positive regulation of MAPK cascade

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0043409

negative regulation of MAPK cascade

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0043132

NAD transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0043085

positive regulation of catalytic activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0043065

positive regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0043029

T cell homeostasis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

part_of

GO:0043025

neuronal cell body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

C

Seeded From UniProt

complete

protected

involved_in

GO:0042493

response to drug

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0042098

T cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

enables

GO:0038023

signaling receptor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

F

Seeded From UniProt

complete

protected

involved_in

GO:0034405

response to fluid shear stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0033198

response to ATP

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0032963

collagen metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0032755

positive regulation of interleukin-6 production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0032731

positive regulation of interleukin-1 beta production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0032496

response to lipopolysaccharide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0032308

positive regulation of prostaglandin secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0032060

bleb assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0031668

cellular response to extracellular stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

part_of

GO:0031594

neuromuscular junction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

C

Seeded From UniProt

complete

protected

involved_in

GO:0030501

positive regulation of bone mineralization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0030163

protein catabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0019233

sensory perception of pain

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0016485

protein processing

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0016079

synaptic vesicle exocytosis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

C

Seeded From UniProt

complete

protected

enables

GO:0015267

channel activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

F

Seeded From UniProt

complete

protected

involved_in

GO:0014070

response to organic cyclic compound

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0014054

positive regulation of gamma-aminobutyric acid secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0014049

positive regulation of glutamate secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0012501

programmed cell death

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0010467

gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0010043

response to zinc ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0010033

response to organic substance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

part_of

GO:0009897

external side of plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

C

Seeded From UniProt

complete

protected

involved_in

GO:0009617

response to bacterium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0009612

response to mechanical stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0008219

cell death

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0007009

plasma membrane organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0007005

mitochondrion organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0006954

inflammatory response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0006900

vesicle budding from membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0006884

cell volume homeostasis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0006816

calcium ion transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0006812

cation transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0006649

phospholipid transfer to membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0006509

membrane protein ectodomain proteolysis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

part_of

GO:0005911

cell-cell junction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

C

Seeded From UniProt

complete

protected

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

C

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

C

Seeded From UniProt

complete

protected

enables

GO:0005524

ATP binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

F

Seeded From UniProt

complete

protected

enables

GO:0004931

extracellularly ATP-gated cation channel activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

F

Seeded From UniProt

complete

protected

involved_in

GO:0001934

positive regulation of protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0001916

positive regulation of T cell mediated cytotoxicity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0001845

phagolysosome assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

enables

GO:0001530

lipopolysaccharide binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

F

Seeded From UniProt

complete

protected

involved_in

GO:0000902

cell morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0000187

activation of MAPK activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0097191

extrinsic apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0072593

reactive oxygen species metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0071407

cellular response to organic cyclic compound

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0071359

cellular response to dsRNA

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0070230

positive regulation of lymphocyte apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0051901

positive regulation of mitochondrial depolarization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0051602

response to electrical stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0051592

response to calcium ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0051259

protein complex oligomerization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0051209

release of sequestered calcium ion into cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0050830

defense response to Gram-positive bacterium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

involved_in

GO:0050718

positive regulation of interleukin-1 beta secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1M0
ensembl:ENSMUSP00000098303

P

Seeded From UniProt

complete

protected

enables

GO:0001614

purinergic nucleotide receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001429
InterPro:IPR003050

F

Seeded From UniProt

complete

protected

enables

GO:0004931

extracellularly ATP-gated cation channel activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001429

F

Seeded From UniProt

complete

protected

enables

GO:0005216

ion channel activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003050

F

Seeded From UniProt

complete

protected

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003050

F

Seeded From UniProt

complete

protected

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001429

C

Seeded From UniProt

complete

protected

involved_in

GO:0006811

ion transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003050

P

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003050

C

Seeded From UniProt

complete

protected

involved_in

GO:0033198

response to ATP

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001429

P

Seeded From UniProt

complete

protected

involved_in

GO:0098655

cation transmembrane transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001429

P

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

PMID:17299767
Reactome:R-HSA-877198
Reactome:R-HSA-877187
Reactome:R-HSA-419490
Reactome:R-HSA-139855

ECO:0000304

author statement supported by traceable reference used in manual assertion





C

part_of:(CL:0000129)

Seeded From UniProt

complete

protected

involved_in

GO:1905114

cell surface receptor signaling pathway involved in cell-cell signaling

PMID:12151016

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

  • occurs_in:(CL:0000129)
  • part_of:(GO:0035585)
  • has_agent:(CL:0000127)

Seeded From UniProt

complete

protected

involved_in

GO:0070588

calcium ion transmembrane transport

PMID:12151016

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

  • occurs_in:(CL:0000129)
  • part_of:(GO:0035585)
  • part_of:(GO:1905114)

Seeded From UniProt

complete

protected

involved_in

GO:0035585

calcium-mediated signaling using extracellular calcium source

PMID:12151016

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

occurs_in:(CL:0000129)

Seeded From UniProt

complete

protected

involved_in

GO:0071318

cellular response to ATP

PMID:12151016

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

  • occurs_in:(CL:0000129)
  • part_of:(GO:0035585)

Seeded From UniProt

complete

protected

involved_in

GO:0007596

blood coagulation

Reactome:R-HSA-109582

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

protected

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

protected

involved_in

GO:0006811

ion transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0406

P

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete




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