GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

TableEdit

Jump to: navigation, search

PMID:11301010

You don't have sufficient rights on this wiki to edit tables. Perhaps you need to log in. Changes you make in the Table editor will not be saved back to the wiki

See Help for Help on this wiki. See the documentation for how to use the table editor

Citation

Cantor, SB, Bell, DW, Ganesan, S, Kass, EM, Drapkin, R, Grossman, S, Wahrer, DC, Sgroi, DC, Lane, WS, Haber, DA and Livingston, DM (2001) BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function. Cell 105:149-60

Abstract

BRCA1 interacts in vivo with a novel protein, BACH1, a member of the DEAH helicase family. BACH1 binds directly to the BRCT repeats of BRCA1. A BACH1 derivative, bearing a mutation in a residue that was essential for catalytic function in other helicases, interfered with normal double-strand break repair in a manner that was dependent on its BRCA1 binding function. Thus, BACH1/BRCA1 complex formation contributes to a key BRCA1 activity. In addition, germline BACH1 mutations affecting the helicase domain were detected in two early-onset breast cancer patients and not in 200 matched controls. Thus, it is conceivable that, like BRCA1, BACH1 is a target of germline cancer-inducing mutations.

Links

PubMed

Keywords

Adult; Amino Acid Motifs/genetics; BRCA1 Protein/metabolism; Binding Sites/physiology; Boston/epidemiology; Breast Neoplasms/epidemiology; Breast Neoplasms/genetics; Cell Line; Chromosomes, Human, Pair 17/genetics; DNA Helicases/genetics; DNA Helicases/metabolism; DNA Repair/genetics; DNA-Binding Proteins; Female; Genetic Predisposition to Disease/genetics; Genetic Testing; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Binding/physiology; Protein Structure, Tertiary/genetics; RNA Helicases/genetics; RNA Helicases/metabolism; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/metabolism; Sequence Homology, Amino Acid; Spectrometry, Mass, Electrospray Ionization; Transfection

public



Cancel